RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제
      • 좁혀본 항목 보기순서

        • 원문유무
        • 원문제공처
        • 등재정보
        • 학술지명
        • 주제분류
        • 발행연도
        • 작성언어
        • 저자
          펼치기

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재후보

        Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

        Chenguang Liu,Wenwen Fan,Xiguang Chen,Chengsheng Liu,Xianghong Meng,Hyun Jin Park 한국물리학회 2007 Current Applied Physics Vol.7 No.s1

        Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-med-iated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles isloading experiments indicate that the loading capacity and eciency increase with increasing concentration of ADR. ADR is slowlyreleased from chitosan self-aggregates for about 3 days. Furthermore, the eects of drug controlled release become more obvious onincreasing the pH value.

      • KCI등재

        Alisol A Inhibited the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells by Inhibiting the Hippo Signaling Pathway

        Xianghong Chen,Huiqing Liu 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.10

        Purpose: Alisol A is a bioactive triterpenoid isolated from the Rhizoma Alismatis. Previous studies have shown that alisol A has anticancer potential. In this study, we explored the effect of alisol A on the growth of nasopharyngeal carcinoma (NPC) cells. Materials and Methods: MTT assay, colony formation assay, flow cytometry, transwell assay, wound healing assay, and western blotting were used to assess cell viability, proliferation, cell cycle, migration, invasion, and protein expression, respectively, in vitro. AutoDock Vina and Discovery Studio software were used for molecular docking. Results: Alisol A inhibited the viability, proliferation, migration, and invasion of NPC cells. The molecular docking simulation assay confirmed that alisol A bound to YAP protein. In addition, alisol A promoted the phosphorylation of YAP and suppressed the expression of YAP in NPC cells. Conclusion: Alisol A inhibited the proliferation, migration, and invasion of NPC cells by inhibiting the Hippo signaling pathway. Alisol A may be a candidate drug for NPC.

      • KCI등재

        Highly extendable multi‑channel LED driver with leakage energy recycling

        Xianghong Kong,Junfeng Liu,Jun Zeng 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.7

        This paper presents a single-stage single-switch multi-channel LED driver with high extendibility. The PFC module adopts a buck–boost circuit, which can achieve a high-power factor when it works in the discontinuous current mode (DCM). At the same time, the leakage inductor energy can be recycled by adding a capacitor at the primary side to reduce the voltage spike and ringing of the switch. The DC–DC module adopts a forward converter that plays the role of electrical isolation. Using capacitor charge balance, the converter can achieve output current balancing of all the channels. This converter can extend the number of output channels while using fewer capacitors than traditional LED drivers based on capacitor charge balance. In addition, the PFC module is integrated with the DC–DC module while sharing a common switch, which makes the control simple. This paper provides the concrete structure, working principle, and circuit characteristic analysis of the proposed topology. Finally, a 100 W prototype was built to verify its feasibility.

      • KCI등재

        Development, characterization, genetic diversity and cross-species/genera transferability of ILP markers in rubber tree (Hevea brasiliensis)

        Dejun Li,Zhihui Xia,Zhi Deng,Xianghong Liu,Fuying Feng 한국유전학회 2013 Genes & Genomics Vol.35 No.6

        To construct a linkage map enriched with tapping panel dryness (TPD)-related markers, we firstly utilized rubber tree ESTs associated with TPD to develop intron length polymorphism (ILP) markers. In this study,52 new ILP markers were further developed. Together with the ILP markers previously reported, 102 ILP markers developed from TPD-related ESTs were analyzed within 39 Hevea germplasm in detail. The PCR success rate and polymorphism rate of ILP markers was 97.06 and 61.62 %,respectively. The results based on PCR amplification and sequence analyses provided the evidences on cross-species/genera transferability of rubber tree ILP markers. The average polymorphic information content (PIC) values of 39 Hevea germplasm were about 0.1719, indicating that the genetic base of Hevea germplasm selected in this study was very narrow. Among 39 Hevea germplasm, the PIC value of wild rubber tree accessions was the highest, followed by Hevea species and cultivated rubber tree clones. Based on the similarity coefficient of ILP markers, 39 Hevea germplasm were divided into three groups including cultivated clones, wild accessions and Hevea species, suggesting that the classification was generally related to the characterization of Hevea germplasm. The ILP markers developed in this study further enriches the number of molecular marker in rubber tree, and the ILP markers will have a wide application in DNA fingerprinting, genetic diversity, marker-assisted selection and genetic mapping, etc. Moreover,the ILP markers transferred cross-euphorbiaceae family might be utilized in cassava, castor bean and physic nut.

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼