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Jian He,Xulin Hu,Luyao Xing,Dongliang Chen,Lijun Peng,Gaofeng Liang,Chengdong Xiong,Xiangchun Zhang,Lifang Zhang 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-
Tissue-engineered scaffolds acted as active natural extracellular matrices that allowed for cellattachment, migration, proliferation, and differentiation. To enhance the drug loading, degradationcontrol, and mechanical features of tissue-engineered scaffolds used in bone regeneration applications,we synthesized novel poly(trimethylene carbonate) (PTMC)/modified HA nanoparticles (KHA NPs,modified by silane coupling agent)/vancomycin hydrochloride (VH) porous microspheres scaffold. Thefabricated PTMC/KHA/VH scaffold has unique surface corrosion degradation, excellent surface properties,and high cytocompatibility. The novel PTMC/KHA/VH scaffold was characterized by 42% porosity,100 mmpore size, and 208.2 MPa compressive modulus. After the treatment of a rat femur defect for 4, 8, and 12weeks, the surface corrosion biodegraded of the PTMC/KHA/VH scaffold remarkably decreasedinflammation response and promoted bone regeneration, suggesting its use as a bioactive structurein bone tissue engineering.