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Jian He,Xulin Hu,Luyao Xing,Dongliang Chen,Lijun Peng,Gaofeng Liang,Chengdong Xiong,Xiangchun Zhang,Lifang Zhang 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-
Tissue-engineered scaffolds acted as active natural extracellular matrices that allowed for cellattachment, migration, proliferation, and differentiation. To enhance the drug loading, degradationcontrol, and mechanical features of tissue-engineered scaffolds used in bone regeneration applications,we synthesized novel poly(trimethylene carbonate) (PTMC)/modified HA nanoparticles (KHA NPs,modified by silane coupling agent)/vancomycin hydrochloride (VH) porous microspheres scaffold. Thefabricated PTMC/KHA/VH scaffold has unique surface corrosion degradation, excellent surface properties,and high cytocompatibility. The novel PTMC/KHA/VH scaffold was characterized by 42% porosity,100 mmpore size, and 208.2 MPa compressive modulus. After the treatment of a rat femur defect for 4, 8, and 12weeks, the surface corrosion biodegraded of the PTMC/KHA/VH scaffold remarkably decreasedinflammation response and promoted bone regeneration, suggesting its use as a bioactive structurein bone tissue engineering.
Xiliang Liu,Song Liu,Youkun Fan,Jin Qi,Xin Wang,Wei Bai,Dongliang Chen,Chengdong Xiong,Lifang Zhang 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-
The poly(L-lactide-co-e-caprolactone) (PLCL) ureteral stent creeps and loses shape stability, increasingthe risk of stent tube dislocation. The rubbery biodegradable cross-linked PLCL networks were preparedthrough gamma irradiation under vacuum in the presence of trimethylolpropane triacrylate (TMPTA),pentaerythritol tetraacrylate (PET4A), and pentaerythritol triacrylate (PETA). At a standard sterilizationdose of 25 kGy, the gel content and network density of PLCL networks increased with increasingcrosslinking agent content (1, 3, 5, 7 wt%), and crosslinking efficiency decreased in the order ofPETA > PET4A > TMPTA. The average molecular weight (Mc ) between two crosslinks ranged from 2000to 105 g/mol. To perform the beneficial semi-interpenetrated polymer network and characterized bythe principle, the networks were processed in several doses (25, 50, 75, 100, and 125 kGy). In place ofthe Charlesby-Pinner equation, the irradiation cross-linking followed the Chen-Liu-Tang equation. ThePLCL network with 7 wt% PETA had a gel fraction of 83%, tensile strength of 34.7 MPa, and tensile setvalue as low as 5%. Furthermore, degradation in vitro was slowed down. Thus, PLCL networks with appropriateelasticity and flexibility, inherent biodegradability, and excellent biocompatibility can provide apromising alternative method for soft tissue repair engineering, such as ureteral stents.