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      • KCI등재

        Independent Correlation of the C1–2 Cobb Angle With Patient-Reported Outcomes After Correcting Chronic Atlantoaxial Instability

        Zhimin Pan,Yanhai Xi,Wei Huang,김긍년,이성,신동아,Kai Huang,Yu Chen,Zhongren Huang,Da He,하윤 대한척추신경외과학회 2019 Neurospine Vol.16 No.2

        Objective: To investigate three-planar radiographic results and patient-reported outcomes (PROs) after correcting chronic atlantoaxial instability (AAI) by translaminar screw (TLS) and pedicle screw (PS) fixation, and to explore the potential association of atlantoaxial realignment with PRO improvements. Methods: Twenty-three patients who underwent C1 lateral mass screw (LMS)-C2 TLS and 29 who underwent C1 LMS-C2 PS with ≥2 years of follow-up were retrospectively analyzed. Three-planar (sagittal, coronal, and axial) radiographic parameters were measured. PROs including the Neck Disability Index (NDI), Japanese Orthopaedic Association (JOA) score and the Short Form 36 Physical Component Summary (SF-36 PCS) were documented. Factors potentially associated with PROs were identified. Results: The radiographic parameters significantly changed postoperatively except the C1–2 midlines’ intersection angle in the TLS group (p=0.073) and posterior atlanto-dens interval in both groups (p=0.283, p=0.271, respectively). The difference in bilateral odontoid lateral mass interspaces at last follow-up was better corrected in the TLS group than in the PS group (p=0.010). Postoperative PROs had significantly improved in both groups (all p<0.05). Thereinto, NDI at last follow-up was significantly lower in the TLS group compared with PS group (p=0.013). In addition, blood loss and operative time were obviously lesser in TLS group compared with PS group (p=0.010, p=0.004, respectively). Multivariable regression analysis revealed that a change in C1–2 Cobb angle was independently correlated to PROs improvement (NDI: β=-0.435, p=0.003; JOA score: β=0.111, p=0.033; SF-36 PCS: β=1.013, p=0.024, respectively), also age ≤40 years was independently associated with NDI (β=5.40, p=0.002). Conclusion: Three-planar AAI should be reconstructed by C1 LMS-C2 PS fixation, while sagittal or coronal AAI could be corrected by C1 LMS-C2 TLS fixation. PROs may improve after atlantoaxial reconstruction in patients with chronic AAI. The C1–2 Cobb angle is an independent predictor of PROs after correcting chronic AAI, as is age ≤40 years for postoperative NDI.

      • KCI등재후보

        Analytical calculation method for the axial equivalent elastic modulus of laminated FRP pipes based on three-dimensional stress state

        Li Chen,Darong Pan,Qilin Zhao,Li-Cheng-Xi Huang,Liang Chen,Wei Xu 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.77 No.1

        In engineering design, the axial equivalent elastic modulus of laminated FRP pipe was mostly calculated by the average elastic modulus method or the classical laminated plate theory method, which are based on relatively simplified assumptions, and may be not accurate enough sometimes. A new analytical calculation method for the axial equivalent elastic modulus of laminated FRP pipe was established based on three-dimensional stress state. By comparing the results calculated by this method with those by the above two traditional analytical methods and the finite element method, it is found that this method for the axial equivalent elastic modulus fits well not only for thin-walled pipes with orthotropic layers, but also for thick-walled pipes with arbitrary layers. Besides, the influence of the layer stacking on the axial equivalent elastic modulus was studied with this method. It is found that a proper content of circumferential layer is beneficial for improving the axial equivalent elastic modulus of the laminated FRP pipe with oblique layers, and then can reduce its material quantity under the premise that its axial stiffness remains unchanged. Finally, the meso-mechanical mechanism of this effect was analyzed. The improving effect of circumferential layer on the axial equivalent elastic modulus of the laminated FRP pipe with oblique layers is mainly because that, the circumferential fibers can restrain the rigid body rotations of the oblique fibers, which tend to cause the significant deformations of the pipe wall units and the relatively low axial equivalent elastic modulus of the pipe.

      • KCI등재

        THEORETICAL AND EXPERIMENTAL STUDY ON FLOW CHARACTERISTICS OF A DIAPHRAGM PUMP FOR UREA-SCR SYSTEMS

        Shu Dong Yang,You Cheng Shi,Xi Wei Pan,Yin Shui Liu 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.4

        Urea selective catalytic reduction (SCR) is the primary technology used to reduce the nitrogen oxides (NOx) of diesel engine exhaust. To meet the requirements of an SCR system, a novel type of miniature diaphragm pump was designed. Based on the theory of large deflection of annular plates, the equilibrium equations of a diaphragm with a rigid inclusion were established, and the equations were solved by the nondimensional method and the finite difference method. Theoretical and approximated flow model for this pump were proposed. A theoretical relationship between back pressure, rigid inclusion size and volumetric efficiencies were calculated. To verify the validity of theoretical model, a prototype pump was fabricated and tested. Experimental results demonstrated that the flow is proportional to the pump speed. The deviation between theoretical, approximated flow and experimental flow was less than 4 % and 9.4 %, respectively. The difference between theoretical and experimental volumetric efficiency was varied from 2.7 % to 6.1 % when back pressure changed from 0 to 0.9 MPa. The volumetric efficiency was growing with the increasing of the rigid inclusion size. The pressures in the working chamber showed almost the same overall trends between the theoretical results and experimental values. The experimental results show that the proposed theoretical model is effective.

      • G1/S-specific Cyclin-D1 Might be a Prognostic Biomarker for Patients with Laryngeal Squamous Cell Carcinoma

        Zhang, Ying-Yao,Xu, Zhi-Na,Wang, Jun-Xi,Wei, Dong-Min,Pan, Xin-Liang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

        Objective: To investigate the prognostic role of antigen KI-67 (Ki-67) and G1/S-specific cyclin-D1 (cyclin-D1) in patients with laryngeal squamous cell carcinoma (LSCC). Methods: Immunohistochemical staining (IHS) was used to determine the protein expression of Ki-67 and cyclin-D1 in LSCC tissues. Kaplan-Meier survival curves was calculated with reference to Ki-67 and cyclin-D1 levels. Results: Cyclin-D1 and Ki67 were expressed in the nuclei of cancer cells. Among the total of 92 cancer tissues examined by immunohistochemistry, 60 (65.22%) had cyclin-D1 overexpression and 56 (60.87%) had Ki67 overexpression. Cyclin-D1 overexpression is associated with the advanced stage of the cancer (P=0.029), but not with gender, age, stage of cancer, histological differentiation, anatomical site, smoking history and alcohol consumption history. Ki67 overexpression is not associated with the advanced stage, gender, age, histological differentiation, anatomical site, smoking history and alcohol consumption history. A statistically significant correlation was found between lymph node status and the expression of Ki67 (p = 0.025). Overexpression of cyclin-D1 was correlated to shorter relapse-free survival period (P<0.001). Conclusions: Overexpression of cyclin-D1 can be used as a marker to predict relapse in patients with LSCC after primary curative resection.

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