HCV-Specific Interleukin-21+CD4+ T Cells Responses Associated with Viral Control through the Modulation of HCV-Specific CD8+ T Cells Function in Chronic Hepatitis C Patients

Guo-Hua Feng,Fu-Sheng Wang,Ji-Yuan Zhang,Qing-Lei Zeng,Lei Jin,Junliang Fu,Bin Yang,Ying Sun,Tianjun Jiang,Xiangsheng Xu,Zheng Zhang,Jinhong Yuan,Liyuan Wu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4

Interleukin-21 (IL-21)+CD4+ T cells are involved in the immune response against hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+CD4+ T cells in the immune response against chronic hepatitis C (CHC) virus infection is poorly understood. This study aimed to investigate the role of IL-21+CD4+ T cells in CHC patients and the potential mechanisms. The study subjects in-cluded nineteen CHC patients who were grouped by viral load (low, < 106 RNA copies/ml, n = 8; high, > 106 RNA copies/ml, n = 11). The peripheral frequency of HCV-specific IL-21+CD4+ T cells was higher in the low viral load group and was negatively correlated with the serum HCV RNA viral load in all CHC patients. Meanwhile, IL-21+ cells accumulated in the liver in the low viral load group. In vitro, IL-21 treatment increased the expression of proliferation markers and cytolytic molecules on HCV-specific CD8+ T cells. In summary, these findings suggest that HCV-specific IL-21+CD4+ T cells might contribute to HCV control by rescuing HCV-specific CD8+ T cells in CHC patients.

P型 α-多孔 SiC. 的光致發光光潽硏究

이기환,김영유,두영뢰,우배매 公州大學校 基礎科學硏究所 1998 自然科學硏究 Vol.7 No.-

The photoluminescence (PL) spectra from p-type a-porous silicon carbides prepared under UV photo-assisted process and under dark-current condition are investigated in detail. Emission bands with peak energies of 2.35, 2.50, 2.70, and 3.43 are resolved. The PL stability in tune and the PL difference arising from different tuning excitation energies are studied. It is found that the PL spectra of the a-porous silicon carbide depend strongly on the preparation conditions for electrochemical etching. The PL spectrum of the sample prepared under photo-assisted process has an enhancement on the lower-energy side of the emission; on the contray, another one under dark-current condition has an enhancement at the higher energy side, and the former stability is better than the latter one, and the latter PL intensity decreases with the increase of the time in the air. The reasons about these differences are discussed.

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient with Systemic Lupus Erythematosus

Ying-Ying Wu,Yan Feng,Yue Huang,Jie-Wen Zhang 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.4

Synthesis and SAR of Thiazolidinedione Derivatives as 15-PGDH Inhibitor

Ying WU,Hoon CHO 한국생물공학회 2009 한국생물공학회 학술대회 Vol.2009 No.10

The Expression of Postmodern Pop Art Style in Contemporary American Animation

Ying Wu(우잉),Wook-sang Chang(장욱상) 한국콘텐츠학회 2022 한국콘텐츠학회논문지 Vol.22 No.4

이 글은 1990년대 이후 미국 애니메이션을 연구 대상으로 삼았으며, 현대 팝 예술 양식을 대상으로 현대팝 예술 양식이 당대 미국 애니메이션 예술 창작 표현과 당대 미국 애니메이션에 미치는 영향을 세밀하게 정리하였다. 미국 애니메이션이 세계를 휩쓴 이유를 알고, 현대 미국 애니메이션의 예술 창작 특징을 정리한다. 당대 미국 애니메이션과 긴밀한 관계를 맺고 있는 포스트모던 팝의 예술 양식이 당대 미국 애니메이션에서 어떻게 표현되고 있는지 살펴본다. 이론과 실제 애니메이션 작품을 결합한 연구 논증을 거친 후, 현대 미국 애니메이션에서 포스트모던 팝의 주요 표현 방법인 과장되고 심플한 조형을 통한 캐릭터 특징 부각, 반항적인 색채를 이용한 정서적 감각의 재구성, 대중매체를 이용하는 창작활동, 반복되는 요소 간의 조합과 같은 방식을 이용하는 장난스러우며 기존의 것을 희화화 하는 포스트모던의 정신을 구현한다. 이를 통해 현재 미국 애니메이션의 분석이 국내 애니메이션 디자인에 새로운 혁신 아이디어를 제공하고, 국제 영상 애니메이션에서 국내 애니메이션의 경쟁력을높여 줄 것으로 기대한다. This article focused on contemporary American animation since the 1990s and later detailed clues to the theory that contemporary pop art style influenced contemporary American animation art creation expression and contemporary American animation. Knowing why American animation swept the world summarizes the art creation characteristics of modern American animation. After a combination of theoretical and actual animation works, the main manifestations of the postmodern pop art style in contemporary American animation: exaggerated and superficial shapes highlight character characteristics; rebellious colors reconstruct emotional perception; creation impacts the mass media—dependence; bizarre collage and repetition, embodying the postmodern pop spirit of jokes and spoofs, Etc. Through this, it is expected that the current analysis of American animation will provide new innovative ideas for domestic animation design and increase the competitiveness of domestic animation in international video animation.

Magnetic Resonance Image Manifestations of the Atypical Meningioma

Wu, Qing-Wu,Yan, Rui-Fang,Li, Qiang,Hu, Ying,Zhou, Feng-Mei,Ren, Ji-Peng,Yang, Rui-Min,Zhang, Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Through retrospective analysis of 13 cases of magnetic resonance image (MRI) manifestations of atypical meningiomas confirmed by operation and pathology in the First Affiliated Hospital of Xinxiang Medical University, the objective of this study was to evaluate the diagnostic value of MRI in order to improve the accuracy rate of preoperative diagnosis. In this retrospective analysis of MRI findings for atypical meningiomas in First Affiliated Hospital of Xinxiang Medical University from January to July in 2012, the location, morphology and tumor signals and other tumor imaging characteristics were covered. In 13 cases of atypical meningioma patients of this group, most tumors were located at typical sites (10/13), mainly the falx cerebri, parasagittal, convexity, saddle area. Only two cases were at atypical locations, 1 in the cerebellar hemisphere and 1 in a lateral ventricle. Most of the tumors showed T1 and T2 isointensity signals, and necrosis, calcification, and peritumoral edema were always featured. DWI showed isointensity in 11 cases (11/13), and hyperintensity in 2. Some 9 cases had dural tail signs, 12 had accurate positioning (12/13), and 2 were postoperative recurrences. MRI has high value in the diagnosis of atypical meningiomas, with important roles in early clinical diagnosis, treatment and prognosis evaluation.

Residual Stress in Oil and Gas Pipelines with Two Types of Dents during Different Lifecycle Stages

Ying Wu,Rong Zou,Yihuan Wang,Guojin Qin 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.6

The residual stress at a dented area is critical to oil and gas pipelines’ integrity and safe operation. A three-dimensional (3D) finite element-based model was developed to investigate the residual stresses in two typical dented areas during the lifecycle stages (pipeline construction and pipeline operation stages). Use of this model enables study of the distribution of the maximum residual stress (σRS) in the dented area. The effects of indenter size, pipeline size, internal pressure and dent depth on the residual stress of two types of dented pipelines were analyzed. A nonlinear regression analysis was used to obtain multi-factor formulas for predicting the σRS for different dents during different lifecycle stages. The results show that the σRS distribution in the dented area changes with dent depth. With σRS for a transversal dent being almost always greater than that for a longitudinal dent. During the pipeline construction stage, the influence of indenter size or pipeline size on σRS is almost the same for the two types of dent, whereas, during the pipeline operation stage, the influences are distinct. The tendency for pipeline size to affect σRS differs slightly as the dent depth increases. Multivariate fitting formulas can provide a reference for estimating σRS.

Unified plastic-damage model for concrete and its applications to dynamic nonlinear analysis of structures

Wu, Jian-Ying,Li, Jie Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.25 No.5

In this paper, the energy-based plastic-damage model previously proposed by the authors [International Journal of Solids and Structures, 43(3-4): 583-612] is first simplified with an empirically defined evolution law for the irreversible strains, and then it is extended to its rate-dependent version to account for the strain rate effect. Regarding the energy dissipation by the motion of the structure under dynamic loadings, within the framework of continuum damage mechanics a new damping model is proposed and incorporated into the developed rate-dependent plastic-damage mode, leading to a unified constitutive model which is capable of directly considering the damping on the material scale. Pertinent computational aspects concerning the numerical implementation and the algorithmic consistent modulus for the unified model are also discussed in details, through which the dynamic nonlinear analysis of damping structures can be coped with by the same procedures as those without damping. The proposed unified plastic-damage model is verfied by the simulations of concrete specimens under different quasistatic and high rate straining loading conditions, and is then applied to the Koyna dam under earthquake motions. The numerical predictions agree fairly well with the results obtained from experimental tests and/or reported by other investigators, demonstrating its capability for reproducing most of the typical nonlinear performances of concrete under quasi-static and dynamic loading conditions.

The influence of conuntermeasure on debris flow hazards with numerical simulation

( Ying Hsin Wu ),( Ko Fei Liul ),( Byung Gon Chae ) 대한지질공학회 2013 대한지질공학회 학술발표회논문집 Vol.2013 No.1

Ginsenoside Rg3 in combination with artesunate overcomes sorafenib resistance in hepatoma cell and mouse models

Ying-Jie Chen,Jia-Ying Wu,Yu-Yi Deng,Ying Wu,Xiao-Qi Wang,Amy Sze-man Li,Lut Yi Wong,Xiuqiong Fu,Zhi-Ling Yu,Chun Liang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3

Sorafenib is effective in treating hepatoma, but most patients develop resistance to it. STAT3signaling has been implicated in sorafenib resistance. Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3)have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells. This study aimed to evaluatethe effects of Rg3 in combination with ART (Rg3-plus-ART) in overcoming sorafenib resistance, and toexamine the involvement of STAT3 signaling in these effects. Methods: Sorafenib-resistant HepG2 cells (HepG2-SR) were used to evaluate the in vitro anti-hepatomaeffects of Rg3-plus-ART. A HepG2-SR hepatoma-bearing BALB/c-nu/nu mouse model was used to assessthe in vivo anti-hepatoma effects of Rg3-plus-ART. CCK-8 assays and Annexin V-FITC/PI double stainingwere used to examine cell proliferation and apoptosis, respectively. Immunoblotting was employed toexamine protein levels. ROS generation was examined by measuring DCF-DA fluorescence. Results: Rg3-plus-ART synergistically reduced viability of, and evoked apoptosis in HepG2-SR cells, andsuppressed HepG2-SR tumor growth in mice. Mechanistic studies revealed that Rg3-plus-ART inhibitedactivation/phosphorylation of Src and STAT3 in HepG2-SR cultures and tumors. The combination alsodecreased the STAT3 nuclear level and induced ROS production in HepG2-SR cultures. Furthermore, overactivation of STAT3 or removal of ROS diminished the anti-proliferative effects of Rg3-plus-ART, andremoval of ROS diminished Rg3-plus-ART's inhibitory effects on STAT3 activation in HepG2-SR cells. Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms. Thisstudy provides a pharmacological basis for developing Rg3-plus-ART into a novel modality for treatingsorafenib-resistant hepatoma.