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Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells
박영한,김수진,정병훈,Thomas J Herzog,Jason Wright,Jan Kitajewski,임채춘,장봉림,강정배,김성주 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.2
Objective: Notch is known as a transmembranous receptor family with four homologous forms - Notch 1, Notch 2,Notch 3, and Notch 4 and related to cell fate regulation and angiogenesis. The purpose is to investigate the effect of follicular stimulating hormone (FSH) on the Notch 1 expression and proliferation in ovarian cancer cells. Methods: Human ovarian cancer cell line, SK-OV-3 and FSH were used. XTT cell proliferation and cell migration assay were carried out with FSH 100 mIU/mL and Notch 1 siRNA. Western blots and reverse transcriptase-polymerase chain reactions (RT-PCR) were carried out to determine the expression level of the Notch 1 protein and mRNA with FSH treatment in 0, 1, 5, 10, 100, 200, 300 mIU/mL concentrations. Immunofluorescent (IF) stains were performed in SK-OV-3 cell cultures with FSH 100 mIU/mL. Student-t tests were used in statistical analyses. Results: The SK-OV-3 have Notch 1 receptors in their natural status. FSH stimulated SK-OV-3 cells in XTT cell proliferation and cell migration assays and notch 1 siRNA inhibited. The expression level of Notch 1 protein and mRNA were increased in a dose dependent pattern according to FSH concentrations compared to untreated cells. IF stains also showed brighter Notch1 expressions in the FSH treated cells compared to the control cells. Conclusion: FSH enhances proliferation & migration and Notch 1 signaling in SK-OV-3 cells. The Notch signaling probably supports one of the cell proliferating mechanisms of FSH in ovarian cancer cells.
Surgical Management of Pachyonychia Congenita in a 3-Year-Old
Sudduth Jack D.,Clinker Christopher,Holdaway Matthew,Marquez Jessica L.,Veith Jacob,Wright Thomas,Rockwell W. Bradford 대한성형외과학회 2023 Archives of Plastic Surgery Vol.50 No.6
Pachyonychia congenita is a rare genetic disorder characterized by hypertrophic nail plates, hyperkeratotic nail beds, and thickened hyponychium of the fingers and toes, impairing manual dexterity and resulting in poor aesthetics. The current body of literature describes various treatment modalities, but no singular approach has been defined as the gold standard. In this case, the authors employed different surgical techniques for treating pachyonychia congenita to evaluate the most effective approach. A 3-year-old boy presented with hypertrophic nail growth involving all digits of both hands and feet. Three surgical procedures were performed on the patient's fingers and toes using germinal matrix excision (GME) alone, GME plus partial sterile matrix excision (pSME), or GME plus complete sterile matrix excision (cSME). The digits treated with GME + cSME exhibited no recurrence of nail growth. Those treated with GME alone exhibited recurrence of hypertrophic nail growth, although their growth slowed. Excision of GME + cSME prevented recurrence of hypertrophic nails, while GME alone or with pSME led to slower-growing hypertrophic nails. Complete excision of the germinal and sterile matrices with skin graft closure may be a definitive treatment for pachyonychia congenita, but further studies are needed to validate these findings.
Caregiver’s vision of bedding textiles for elderly
Ann Blaylock,Floriana Constantin,Loredana Ligabue,Licia Bocaletti,Barbora Siroka,Jan Siroky,Tom Wright,Thomas Bechtold 한국의류학회 2015 Fashion and Textiles Vol.2 No.1
Senior citizens have specific needs for bedding, clothing, hygiene and medical textiles that are an essential part of their daily life. The “Textiles for Ageing Society (TAGS)” project deals with these specific demands. Caregivers from 6 European countries were asked by means of a semi-structured interview, how bedding textiles can contribute to daily care work. We found that better design could support care work substantially. As examples, in the short term, better design of colour and style should avoid a hospital like appearance, and better control of bed climate will improve a resident’s sleep quality. Long term developments are prevented by a number of barriers. Introduction of new bedding concepts is retarded by the fragmented situation between the elderly, care givers, purchasers, manufacturers, researchers, care organisations and politics which needs to be overcome. Caregivers as experts must be heard and their needs must be transformed into more appropriate, cost effective designs of bedding textiles, which can support to the quality of residents in care homes substantially. More intelligent textiles substantially could contribute to support care workers, however their potential has not been exploited yet.
Kevin A. Hao,Robert J. Cueto,Christel Gharby,David Freeman,Joseph J. King,Thomas W. Wright,Diana Almader-Douglas,Bradley S. Schoch,Jean-David Werthel 대한견주관절학회 2024 대한견주관절의학회지 Vol.27 No.1
Background: Restoration of external (ER) and internal rotation (IR) after Grammont-style reverse shoulder arthroplasty (RSA) is often unreliable. The purpose of this systematic review was to evaluate the influence of RSA medio-lateral offset and subscapularis repair on axial rotation after RSA. Methods: We conducted a systematic review of studies evaluating axial rotation (ER, IR, or both) after RSA with a defined implant design. Medio-lateral implant classification was adopted from Werthel et al. Meta-analysis was conducted using a random-effects model. Results: Thirty-two studies reporting 2,233 RSAs were included (mean patient age, 72.5 years; follow-up, 43 months; 64% female). The subscapularis was repaired in 91% (n=2,032) of shoulders and did not differ based on global implant lateralization (91% for both, P=0.602). On meta-analysis, globally lateralized implants achieved greater postoperative ER (40° [36°–44°] vs. 27° [22°–32°], P<0.001) and postoperative improvement in ER (20° [15°–26°] vs. 10° [5°–15°], P<0.001). Lateralized implants with subscapularis repair or medialized implants without subscapularis repair had significantly greater postoperative ER and postoperative improvement in ER compared to globally medialized implants with subscapularis repair (P<0.001 for both). Mean postoperative IR was reported in 56% (n=18) of studies and achieved the minimum necessary IR in 51% of lateralized (n=325, 5 cohorts) versus 36% (n=177, 5 cohorts) of medialized implants. Conclusions: Lateralized RSA produces superior axial rotation compared to medialized RSA. Lateralized RSA with subscapularis repair and medialized RSA without subscapularis repair provide greater axial rotation compared to medialized RSA with subscapularis repair. Level of evidence: 2A.