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표재성 방광암에서 Bacillus Calmette-Guerin 방광 내 주입요법 : 장기적 추적결과 Long-term Follow up Results
김용웅,왕세환,육승모,한동석,노안식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
To evaluated the results of long-term follow up of superficial bladder cancer patients who were treated with transurethral resection and intravesical BCG therapy. Between April 1989 and December 1997, 65 patients with superficial bladder cancer were treated with TUR-B(Transurethral resection of bladder tumor) and intravesical BCG instillation, and follow-up was performed for 5 years longer, and the mean follow-up duration was 82 months. Of 65 patients, pathologic stage were Ta in 17 cases and T1 in 48 cases and grade were G Ⅰ in 22 cases, G Ⅱ in 35 cases and G Ⅲ in 8 cases. The tumor recurred in 22(33.8%) at the median of 21.8 months and the tumor progressed in 9(13.8%) at the median of 20.8 months. Most of the recurrences and progression were within 3 year(838 and 77%). Progression is more likely in higher grade(G Ⅱ, G Ⅲ) and higher stage(T1). The complete response rate after first and second courses of BCG therapy were 53% and 73% and the 5 and 10 year disease specific survival rates were 89.5 and 78% respectively. The complete response rate after first and second courses of BCG therapywere 53% and 73%. Most of recurrences and progressions were within 3 years of the BCG therapy, but some cases occured after 5 years. Therefore, close long-term follow up is needed.
김웅서 한국환경생물학회 2001 환경생물 : 환경생물학회지 Vol.19 No.3
폐쇄생태계는 연구자가 다양한 환경 요인을 조사 목적에 맞게 조절하여 생태계의 변화를 모니터링 할 수 있는 장점이 있어 영양역학적 연구와 같은 기초학문 연구 뿐만 아니라 독성실험 및 환경오염에 대한 생태계의 변화 실험 등 응용분야에서도 활용도가 높다. 특히 현장에 해양 폐쇄생태계를 설치하기 때문에 실험실에서의 실험보다 자연에 가까운 조건에서 실험을 할 수 있어, 신뢰성 있는 실험 결과를 얻을 수 있다는 장점이 있다. 그러나 국내에서 폐쇄생태계를 활용하여 해양생태계를 연구한 결과는 극히 적다. 이 논문에서는 기존에 국내외에서 제작되어 실험에 사용되었던 폐쇄생태계와 이를 활용한 연구과제를 소개하고, 향후 폐쇄생태계를 활용하여 연구할 수 있는 연구과제를 제안하였다. As researchers can modify environmental factors to fit the purpose of an experiment in monitoring marine ecosystem using enclosed experimental ecosystems, which is a strong advantage of them, mid-sized enclosed experimental ecosystems(mesocosm) are widely used in the world in basic ecology such as trophodynamic study and applied ecology such as the toxicity test of various chemicals and monitoring of ecosystem changes against marine pollution. Application of the mesocosm in the field has a merit to get more reliable result than that from the experiment in the laboratory. However, the result from the mesocosm study in marine ecosystem is very limited in Korea. Mesocosms which had been used in the marine ecological studies in both foreign countries and Korea were summarized, and application of them to the future study in various research field was suggested in this review paper.
김수령,서은영,이웅희,이증훈,이충식 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2
A search for the genes expressed only in gastric cancer may help to define molecular alterations or aid in diagnosis of gastric cancer. Recently, suppression subtractive hybridization (SSH) has been used as an effective technique for detection of differentially expressed genes. We discovered a noble gene which belongs to the Reg family in stomach cancer tissue using the SSH technique. We identified and named the Reg Ⅳ gene that is highly expressed only in gastric tumor tissue. The Reg family gene has a lot of functions of the growth factor and gene regulation. The cathepsin L-12 gene, which is known to exhibit increased expression in breast cancer and some inflammatory conditions, is also expressed in stomach cancer. Expressions were verified by reverse Northern blot analysis and Northern blot analysis. We expect these genes to be used as an important tool for the diagnosis and/or understanding of the pathogenesis of gastric cancer.
여드름양 발진에서의 말라쎄지아 포자 검출 빈도에 관한 연구
박장규,이웅재,김연수,서영준,김경호,이증훈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2
Steroid acne and pityrosporum folliculitis have similar clinical manifestations. So it was not casy to do differential diagnosis of these two diseases. We have tried to find out the different points between these diseases in clinical characteristics, positive rate of the malassezia spores, and their response to antifungal agents. We studied 21 patients with acneiform eruptions which were distinct from acne vulgaris. Patients were divided into two groups by steroid treatment history. Among 21 patients, 6 were administered steroid just before eruption and 15 were free from steroid within 6 months. We have examined malassezia spores with 10% KOH/Parker blue black ink mount from papules, pustules and comedones according to the patients skin lesions. The malassezia spores detected in 5 paticnts(83.3%) in the former and 9 patients(60%) in the latter. In malassezia folliculitis, the frequency of which showed above the (3+) score of malassezia spore under microscopy was higher than in steroid acne. Mean duration of the disease was 70.4 weeks in latter group, which was longer than 5.2 weeks of the former group. And there were some differences between two groups in the distribution of the lesions. Mean treatment duration was same in two groups (4 wks, 3.5 wks). Steroid acne patients would be treated better with antifungal agents than with acne regimens.
Review on LTE-Advanced Mobile Technology
Seo, Dae-woong,Kim, Yoon-Hwan,Song, Jeong-Sang,Jang, Bongseog,Bae, Sang-Hyun The Basic Science Institute Chosun University 2018 조선자연과학논문집 Vol.11 No.4
Long Term Evolution-Advanced (LTE-A) is the next drive in the broadband mobile communication, which allows operators to improve networks performance and service capabilities. LTE-A targets the peak data rates of 1Gbps in the downlink and 500Mbps in the uplink. This requirement is only fulfilled by a transmission bandwidth of up to 100MHz. However the accessibility of such large part of the contiguous spectrum is uncommon in practice. Therefore LTE-A uses some new features on top of the existing LTE standards to provide very high data rate transmission. Some of the most significant features introduced in LTE-A are carrier aggregation, heterogeneous network enhancement, coordinated multipoint transmission and reception, enhanced multiple input and multiple output, and development relay nodes with universal frequency reuse. This review paper presents an overview of the above mentioned LTE-A key features and functionalities. Based on this review, in the conclusion we discuss the current technical challenges for future broadband mobile communication systems.
서혜림,박승범,서국웅,이재규,서혜진 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-
The purpose of this study was to investigate the changes of heart rate(HR), Ventileation, Carbon elimination, Oxygen take, Oxygen uptake per weight, Respiratory Exchange ratio and Breath frequency. To do this, we selected three Synthetic tennis playing surface(A:Synpave Rebound Ace Sample, B:Synpave Rebound Classic Sample, C:Synpave Spring Sample) by using of Austrilian Tennis Open. The result of this study is as follows 1. In the changes of heart rate(HR, beats/min), it is not significantly in a stastics. Tennis playing surface sample A was shown a little bit higher than sample C, sample C was shown a little bit higher than sample B, 2. In the changes of Ventileation(VE, 1/min), it is not significantly in a stastics. Tennis playing surface sample B was shown a little bit higher than sample A·C, sample C was shown a little bit higher than sample A, 3. In the changes of Carbon elimination (Vco2, ml/min), it is not significantly in a stastics. Tennis playing surface sample A was shown a little bit higher than sample B·C, sample B was shown a little bit higher than sample C, 4. In the changes of Oxygen take (Vo2, ml/min), it is not significantly in a stastics. Tennis playing surface sample A was shown a little bit higher than sample B·C, sample B was shown a little bit higher than sample C, 5. In the changes of Oxygen uptake per weight(Vo2/wt, ml/kg/min), it is not significantly in a stastics. Tennis playing surface sample A was shown a little bit higher than sample B·C, sample B was shown a little bit higher than sample C, 6. In the changes of Respiratory Exchange ratio(RER, Vco2/Vo2), it is not significantly in a stastics. Tennis playing surface sample A was shown a little bit higher than sample B·C, sample C was shown a little bit higher than sample B, 7. In the changes of Breath frequency (BF, fre/min), it is not significantly in a stastics. Tennis playing surface sample B was shown a little bit higher than sample A·C.
Seo, Hak-Soo,Jeong, Jin-Yong,Nahm, Min-Yeop,Kim, Sam-Woong,Lee, Sang-Yeol,Bahk, Jeong-Dong Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.2
Previously, we reported the biochemical properties of RGA1 that is expressed in Escherichia coli (Seo et al., 1997). The activities of RGA1 that hydrolyzes and binds guanine nucleotide were dependent on the $MgCl_2$ concentration. The steady state rate constant ($k_{cat}$) for GTP hydrolysis of RGA1 at 2 mM $MgCl_2$ was $0.0075{\pm}0.0001\;min^{-1}$. Here, we examined the effects of pH and cations on the GTPase activity. The optimum pH at 2 mM $MgCl_2$ was approximately 6.0; whereas, the pH at 2 mM $NH_4Cl$ was approximately 4.0. The result from the cation dependence on the GTPase (guanosine 5'-triphosphatase) activity of RGA1 under the same condition showed that the GTP hydrolysis rate ($k_{cat}=0.0353\;min^{-1}$) under the condition of 2mM $NH_4Cl$ at pH 4.0 was the highest. It corresponded to about 3.24-fold of the $k_{cat}$ value of $0.0109\;min^{-1}$ in the presence of 2 mM $MgCl_2$ at pH 6.0.
Expression of Neutrophil Gelatinase-Associated Lipocalin in Skin Epidermis
Seo, Seong Jun,Ahn, Ji-Young,Hong, Chang-Kwun,Seo, Eun-Young,Kye, Kyung-Chae,Lee, Woong-Hee,Lee, Sang-Keun,Lim, Jong-Soon,Hahn, Myong-Joon,Kjeldsen, Lars,Borregaard, Niels,Kim, Chang Deok,Park, Jang-K Elsevier 2006 The Journal of investigative dermatology Vol.126 No.2