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Kim, Hye-Ri,Kumar, Rajesh,Kim, Woori,Lee, Jae Hong,Suh, Myungkoo,Sharma, Amit,Kim, Chang Hoe,Kang, Chulhun,Seung Kim, Jong The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.44
<P>Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.</P>
Kwak, Woori,Kim, Jin-Nam,Kim, Daewon,Hong, Jin Su,Jeong, Jae Hark,Kim, Heebal,Cho, Seoae,Kim, Yoo Yong Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.11
Although growth rate is one of the main economic traits of concern in pig production, there is limited knowledge on its epigenetic regulation, such as DNA methylation. In this study, we conducted methyl-CpG binding domain protein-enriched genome sequencing (MBD-seq) to compare genome-wide DNA methylation profile of small intestine and liver tissue between fast- and slow-growing weaning piglets. The genome-wide methylation pattern between the two different growing groups showed similar proportion of CpG (regions of DNA where a cytosine nucleotide occurs next to a guanine nucleotide in the linear sequence) coverage, genomic regions, and gene regions. Differentially methylated regions and genes were also identified for downstream analysis. In canonical pathway analysis using differentially methylated genes, pathways (triacylglycerol pathway, some cell cycle related pathways, and insulin receptor signaling pathway) expected to be related to growth rate were enriched in the two organ tissues. Differentially methylated genes were also organized in gene networks related to the cellular development, growth, and carbohydrate metabolism. Even though further study is required, the result of this study may contribute to the understanding of epigenetic regulation in pig growth.
Kim, Chul-Jin,Park, Seung Soo,Lee, Hyun-Seo,Chung, Hea-Jong,Choi, Woori,Chung, Jin-Ho,Kim, Jin-Man,Hong, Seong-Tshool Springer-Verlag 2011 Journal of human genetics Vol.56 No.6
<P>Intracranial aneurysm (IA) is characterized by an abnormal bulging of one of the arteries in the brain and is heavily affected by genetic factors. Although IA is a very serious disease because of its severity and prevalence in the general public, the gene causing IA has not yet been identified due mainly to the lack of definitive genetic loci for the disease. Following a model-based family collection that recruited families from a geographically limited area that inherited IA as an autosomal dominant trait, we conducted a genome-wide linkage analysis. Significant evidence of linkage to IA was found on chromosome 8p22.2 with a maximum two-point logarithm of the odds ratio score of 3.61 under an autosomal dominant model of inheritance. The methods described in this study could be applied to localize disease-causing genes of other complex diseases through either a genome-wide linkage analysis or a genome-wide association study.</P>