Four α-Amyrin Triterpenoids, and their Cytotoxicity and Topoisomerase I Inhibition from the Spikes of Prunella vuIgaris

Woo MH,Byun SJ,Lee JE,Kim DH,Son JK,Lee JS,Lee SH,Choi YS 大韓藥學會 2001 大韓藥學會 總會 및 學術大會 Vol.2001 No.2

Three Cytotoxic compounds isolated from the seeds of Pharbitis nil

Woo MH,Lee SH,Lee JS,Son JK,Byun SJ,Lee JE 大韓藥學會 2002 大韓藥學會 總會 및 學術大會 Vol.2002 No.2

Asitrilobin E and asitrin, two novel bioactive Annonaceous acetogenins from the seeds of Asimina triloba

MH Woo,SO Chung,DH Kim 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

산전진단된 거대 선천성 태아 두개내기형종 1 예

우복희,안정자,김영주,정혜원,박미혜,박미영,윤원희,유진아 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9

Massive congenital intracranial teratoma is a very rare. We report the prenatal ultrasonographic diagnosis of a massive intracranial teratoma in a 323 weeks pregnancy associated with severe hydrocephalus and polyhydroamnios. Prenatal ultrasound revealed a large heterogeneous echoic mass which almost replaced the normal intracranial structure. By transabdominal and transvaginal cephalocentesis, fetus was terminated vaginally and safely. We have reviewed with attention to clinical presentation, sonographic characteristics and associated findings and man-agement and prognosis of massive congenital intracranial teratoma.

임신부에서의 50 g-Glucose Challenge Test에 관한 연구

우복희,전선희,신효경,박미혜,임옥경,장병우 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.7

본 연구는 1990년 12월부터 1994년 1월 사이에, 이화대학부속병원 산부인과에 산전진찰을 받은 임신부 중, 임신 제 24주부터 28주사이에 50g-당유발검사를 시행하고, 그 결과가 비정상인 경우에 100 g-경구당부하검사를 시행한 후 본원에서 분만한 임신부 492명을 대상으로 하여 연구한 바로가 다음과 같은 결론을 얻었다. 1. 50g-당유발검사가 130 mg/dl이상이었던 경우는 28.5%였고, 그중 이후 100 g-경구당부하검사를 시행한 임신부중 16.4%에서 임신성 당뇨병이 진단되었다. 2. 50g-당유발검사의 수치는 (130 mg/dl이상)연령의 증가, 임신력 및 HbA1수치, 분만력, 제왕절개술율과 유의한 관계가 있었다(p$lt;0.05). 또한 50 g-당유발검사 및 HbA1의 수치는 임신성 당뇨병의 발생빈도와 비례적인 상관관계가 있었다(p$lt;0.01). 3. 임신성 당뇨병의 위험인자가 있었던 경우, 50 g-당유발검사가 130 mg/dl이상이었을 경우는 77.6%였고, 50 g-당유발검사가 130 mg/dl이상이었을 경우 위험요소가 통계학적으로 유의하게 높았고(p$lt;0.05), 위험인자가 없을 경우의 비정상 50g-당유발검사는 102명으로 23.1%였다. 4. 50g-당유발검사의 임신성 당뇨병 예측에 대한 정확도를 보면, 수치를 130 mg/dl를 기준치로 정하였을 때, 민감도는 100%, 특이도는 74.4%, 정확도는 75.4%였으며, 140mg/dl를 기준치로 하였을 때 민감도는 89.5%, 특이도는 86.3%, 정확도는 86.4%였다. 5. 50g-당유발검사 수치에 HbA1의 결과를 병용하여, HbA1의 수치 8.0%를 기준치로 정하였을때 민감도는 100%이면서 특이도를 높일 수 있었다. 이상의 결과로, 임신중기 임신성 당뇨병의 선별방법으로 50 g-당유발검사를 사용하고, 부가하여 연령, 임신력, HbA1등을 고려한다며, 임신성 당뇨병 진단의 정확도를 높이는 것은 물론, 환자에게 편리함과 경제적 잇점도 줄 수 있으므로, 임신성 당뇨병의 선별방법으로 임신 제 24주부터 28주사이의 50 g-당유발검사는 의의가 크다고 사료된다. It is of clinical importnace to screen gestational diabetes melitus for improvement of maternal morbidity and perinatal mortality caused by diabetes mellitus. In this study, we performed glucose challenge test(GCT), followed by 100g-oral glucose tolerance test(OGTT) in case that the result of 50g-GCT showed serum glucose level higher than 130 mg/dl. Purpose of this study was to evaluate the accuracy of GCT for screening of gestational diabetes mellitus. The author performed the GCT in pregnant women from gestational 24 weeks to gestational 28 weeks who had antenatal care and was delivered at Department of OB & GY of Ewha Womans University Hospital from December, 1990 to January 1994. The results were as follows: 1. When the GCT cut off level was higher than 130 mg/dl, the population was 28.5%, and among them 16.4% was diagnosed as gestational diabetes mellitus. 2. There was statistically significant correlation between CGT level(above 130 mg/dl) and age, gravidity, HbA1, and cesarean section rate(p$lt;0.05). Positive correlation between GCT level and HbA1 were also observed(p$lt;0.01). 3. The risk factors were present in 77.6% and 22.4% in the population showing GCT level higher than 130 mg/dl, and below 130 mg/dl, respectively. 4. When the cut off point of GCT level was 130 mg/dl, sensitivity, specificity and accuracy for gestational diabetes mellitus were 100%, 74.4%, 75.4% and when the cut off point was 140 mg/dl, sensitivity, specificity and accuracy were 89.5%, 86.3%, 86.4%. 5. Whe the GCT level and HbA, level(8.0%) were combined, the author could raise the specificity with 100% of sensitivity. The results of the study indicate that measurement of 50g-GCT, considering age, gravidity and HbA1 would contribute to the diagnostic accuracy of gestational diabetes mellitus, and the convenience and cost-effectiveness of patients. In conclusion, the measurement of 500g-GCT is very hilpful to the screening of gestational diabetes mellitus.

폐경기 여성에서 골다공증 위험인자

우복희,유한기,안정자,박미혜 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.12

1994년 1월 1일부터 1995년 2월말까지 이화대학병원 산부인과에 내원하여 골밀도를 측정한 자연적 또는 수술적 폐경여성 195명을 대상으로 하여 골다공증군과 정상군으로 나누어 임상적, 통계적 고찰을 하여 다음과 같은 결과를 얻었다. 1. 195례중 자연폐경은 163례(83.6%), 수술폐경은 32례(16.4%)였고 이중 다공증의 빈도는 60례로 30.8%였다. 2. 골다공증군에서 연령, 폐경기간, 분만회수, 혈증 alkaline phoaphatase 및 에스트라디올(estradiol)농도가 비골다공증군에 비해 유의하게 차이가 있었다. 3. 체형,임신회수, 혈중 칼슘 및 인농도, 혈청지질농도는 골다공증군과 비골다공증군간에 통계적 유의성이 없었다. 이상으로 폐경기 여성에서 고령, 분만횟수증가, 장기간의 폐경기간, 높은 혈중 alkaline phosphatase치 및 낮은 혈중 estradiol은 골다공증의 예견지표로서 가치가 있다고 하겠다. This study was performed to detect the risk factors of osteoporosis in the menopausal women and also protect from the osteoporosis. 195 menopausal women (163 women with spontaneous menopause and 32 women with surgical menopause) were taken part in the study at the Esha Womans University Hospital, during the 14 months from Jan. 1994 to Feb. 1995. 135 women of non-osteoporotic group and 60 women of osteoporotic group were divided by measurements of bone mineral densities of lumbar spine (L2-L4) and ward triangle. Several risk factors of osteoporosis were compared and analysed between these two groups. Students t-test and chi-squre test were used for statistical comparison. The results obtained were as follows : 1. The incidence of osteoporosis was 30.8% of 195 menopausal women. 2. The age, duration of menopause, number of full term delivery, and serum alkaline phospause and estradiol concentration were significantly differnt in the osteoporotic group and the non-osteoporotic group. 3. The anthrophometric measurements, number of pregnancy, serum calcium, serum phosphorous concentration, and serum lipid profiles were not significantly different in the osteoporotic group and non-osteoporotic group. Conclusion : Age, duration of menopause, number of full term delivery and serum alkaline phosphatase and estradiol concentration are the risk factors that influences osteoporosis in the menopausal women.

말기 정상단태임신에 있어서 모체혈청 알파 - 태아단백농도에 영향을 미치는 요인에 관한 연구

우복희,안정자,김승철,박미혜 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.1

This study was purosed to investigate maternal and fetal clinical parameters effecting on maternal serum alpha-fetoprotein(MSAFP) levels at late normal singleton pregnancies. The subjects of this study were 171 pregnant women with gestational age of 36 to 42 weeks, and didn`t have any medical or gynecologic diseases. They delivered fetuses within three days after blood test of MSAFP. MSAFP levels were measured by enzyme- immunoassay. The analysed clinical parameters included fetal sex, fetal weight, gestatioal age, maternal age, gravidity, parity, maternal weight and maternal total weight gain during pregnancy. The results were as follows: At uncomplicated late pregnancies, 1. Male fetus bearers had higher MSAFP(mean: 191.8 ng/ml, SD: 80.8 ng/ml, n=79) than female-fetus bearers(mean 153.6 ng/ml, SD 73.0 ng/ml, n=92)(p=0.0014). 2. Multiparas had higher MSAFP(mean: 192.7 ng/ml, SD: 77.9 ng/ml, n=80) than nulliparas(mean: 152.3 ng/ml, SD 75.1 ng/ml, n=91)(p=0.0007). 3. MSAFP did not have correlation with maternal age, maternal weight, maternal total wight gain during pregnancy, gestational age, fetal weight. According to the above results, fetal sex and parity are the factors that influences MSAFP levels at uncomplicated late pregnancies. So MSAFP values should be interpreted with cautions.

조기진통 임신부의 양수내 Interleukin-6 및 양막 융모막염의 관련성에 관한 연구

우복희,안정자,김영주,박미혜,정화순 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.2

Objective: Our purpose was to determine whether amniotic amniotic fluid concentrations of interleukin-6 are valuable in the prediction of histologic chorioamnionitis and in the prediction of perinatal morbidity. Study Design: The relation among amniotic fluid imterleukin-6, histologic chorioamnion- itis, and perinatal outcome was examined in patients with preterm labor and intact membranes. Interleukin-6 was determined by ELISA method. Results: Patients with histologic chorioamnionitis had significantly higher amniotic fluld interleukin-6 concentrations than patient without histologic chrioamnionitis. Also, patient with histologic chorioamnioitis had significantly higher perinatal morbidity rate than patient without histologic chorioamnionitis. An ammiotic fluld interlerkin-6 concentration had a sensitivity of 75% and a specificity of 62.5% in the diagnosis of preterm delivery. Conclusion: Amniotic fluld interleukin-6 is a sensitive test for the prediction of histologic chorioamnionitis and of perinatal morbidity.

폐경기 여성에서 경피적 에스트로젠 투여후 생물학적 영향에 대한 연구

우복희,유한기,신효경,박미혜,임옥경,장병우,신정현 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.9

1992년 9월부터 5월까지 이화여자대학교 부속병원 산부인과 외래를 내원한 폐경기 환자 43명을 대상으로 경피적 에스트라디올(Estraderm TTS) 50 micro g투여(치료군 I)와 100 micro g투여(치료군 II)에 따르는 생물학적 영향에 따른 연구를 시행하여 다음과 같은 결론을 얻었다. 1. 혈중 에스트론치의 변동은 치료군 I, II에서 각각 34.2+-3.42 pg/dl, 34.0+-5.72 pg/dl로 통계학적으로 유의한 증가를 보였으나(p$lt;0.05) 양 군간에 치료후 변동은 유의한 차이가 없었다(p$gt;0.05). 혈중 에스트라디올 치의 변동은 치료군 I에서 14.9+-1.54 pg/dl이고 치료군 II에서 15.3+-0.89 pg/dl로 통계학적으로 유의한 증가를 보였으며(p$lt;0.05) 치료군 I, II 간의 치료후 변동간에는 유의한 차이가 없었다(p$gt;0.05). 2. 혈중 FSH의 변동은 치료군 I과 치료군 II에서 각각 23.5+-4.55 mIU/ml, 24.5+-3.05 mIU/ml, LH의 변동은 치료군 I과 치료군 II에서 각각 14.5+-2.19 mIU/ml, 22.0+-3.53 mIU/ml로 FSH와 LH 모두 통계학적으로 유의한 감소를 보였으며(p$lt;0.05) FSH와 LH 모두 양 군간에 치료후 변동은 유의한 차이가 없었다(p$lt;0.05). 3. 혈중 renin substate치의 변화는 치료군 I과 치료군 II에서 각각 0.31+-0.002ng/ml, sex hormone binding globulin(SHBG)치의 변화는 2.3+-0.35nM/l으로 통계학적으로 유의하지 않았으며(p$gt;0.05) 양군간에 치료후 변동도 유의한 차이가 없었다(p$gt;0.05). 4. 혈중 총 콜레스테롤, trglyceride, 고밀도 지단백 농도의 변화는 치료군 I에서 각각 9.6+-1.58 mg/dl, 1.4+-0.01 mg/dl, 6.5+-0.29 mg/dl, 2.4+-0.01 mg/dl, 1.0+-1.55 mg/dl로 통계학적으로 유의한 변화를 보이지 않았으나(p$gt;0.05) 저밀도 저단백 농도의 변화는 치료군 I과 치료군 II에서 각각 18.8+-16.36 mg/dl, 18.5+-0.94 mg/dl로 유의성있게 감소하였다(p$lt;0.05). 양군간의 치료후 변동간에는 유의한 차이가 없었다(p$lt;0.05). 5. 골밀도를 간접적으로 측정한 소변내 칼슘, calcium/creatinine비, hydroxyproline/creatinine비는 양 치료군에서 통계학적으로 유의한 감소를 보였다(p$lt;0.05). 이상의 결과 경괴적 에스트라디울 투여법은 경구적 투여법이 필요로 하는 일일 용량보다 적은 량으로 치료혈중 농도를 유지하며 지속적인 생물학적 활성을 나타내며 간에서의 'first pass effect'을 최소화시키면서 효과적인 여성 호르몬의 증가 및 이에 다른 심혈관계 질환의 예방과 골다공의 예방에 적절한 치료법으로 사료된다. Systemic side effects that result from oral administration of estrogens to postmenopausal women may be minimized by use of the trasdemal route. We administred transdermal estrodiol, 50 ug(to 23 postmenopausal women), 100 ug (to 20 postmenopausal women) cyclically for 3 months to 43 postmenopausal women to study the bilogical effect. The results were follows: 1. The plasma estradiol and estrone after trasdermal estradiol therapy in Group II were increased significantly(p0.05). 2. The plasma FSH and LH after transdermal estradiol therapy in Group I and Group II were decreased significantly (p0.05). 3. The change of plasma SHBG and Renin substrate after transdermal estradiol therapy in Group I and Group II were not statistically significant(p$gt;0.05), and difference of changes between two groups was not statistically significant(p$gt;0.05). 4. The changes of plasma total cholesterol, triglyceride, and HDL-cholesterol after transdermal estradiol therapy in Group I and Group II were not statistically significant(p$gt;0.05) but plasma LDL-cholesterols after transdermal estradiol therapy in both groups were statistically significant(p0.05). 5. The changes of urinary calciu, calcuim/creatinine ratio, hydroxyproline/creatinine ratio were not statistically significant in both groups(p0.05). These data indicate that transdermal estradiol can elicit many of the desirable actions of estrogen while avoiding the pharmacologic effects of oral estrogens on hepatic proteins.

건삭 파열의 임상적 특성 및 외과적 치료 변화 추이

김은택,김무현,양두경,박태호,정원택,배이지,차광수,김영대,김종성,조광조,우종수 대한순환기학회 2001 Korean Circulation Journal Vol.31 No.12