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Bioactive α-Pyrone Derivatives from the Endolichenic Fungus <i>Dothideomycetes</i> sp. EL003334
Kim, Gil Soo,Ko, Wonmin,Kim, Jong Won,Jeong, Min-Hye,Ko, Sung-Kyun,Hur, Jae-Seoun,Oh, Hyuncheol,Jang, Jae-Hyuk,Ahn, Jong Seog American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.4
<P>Two new α-pyrones, dothideopyrones E (<B>1</B>) and F (<B>2</B>), were isolated from a culture of the endolichenic fungus <I>Dothideomycetes</I> sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher’s method. Compound <B>2</B> inhibited nitric oxide (NO) production with IC<SUB>50</SUB> values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound <B>2</B> diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, <B>2</B> decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.</P> [FIG OMISSION]</BR>
Experience Self-Directed Practice of Nursing Skills Using Augmented Reality-Based Simulation
Kyungsun Kim,Jiyoung Seo,Wonmin Jeong,Hyeoncheol Jeong 물리치료재활과학회 2023 Physical therapy rehabilitation science Vol.12 No.4
Objective: The purpose of this study was to identify the meaning and essential themes of nursing students' experiences afterimplementing nursing skills self-directed practice training using augmented reality simulation. Design: Qualitative research with phenomenological methodsMethods: The participants of the study were 17 nursing students enrolled in a university, and in-depth interviews were conductedfrom December 1 to December 28, 2020. The collected data were analyzed by applying Giorgi’s phenomenological researchmethod. Results: The analysis revealed four components of the simulation training experience: ‘discomfort of unfamiliarity’, ‘motivatingpractice’, ‘dynamic screen’, and ‘learning effectiveness’, and the analysis yielded up to 15 sub-components and 82 means ofcentrality. Conclusions: This study provided an in-depth understanding of nursing students' self-directed practice education experience,which can be used as a basis for improving various self-directed practice methods in the future.
Lee, Dong-Sung,Kim, Kyoung-Su,Ko, Wonmin,Li, Bin,Jeong, Gil-Saeng,Jang, Jun-Hyeog,Oh, Hyuncheol,Kim, Youn-Chul Molecular Diversity Preservation International (MD 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.5
<P>Sulfuretin is one of the major flavonoid components in <I>Rhus verniciflua</I> Stokes (Anacardiaceae) isolates. In this study, we investigated the protective effects of sulfuretin against <I>tert</I>-butyl hydroperoxide (<I>t</I>-BHP)-induced oxidative injury. The results indicated that the addition of sulfuretin before <I>t</I>-BHP treatment significantly inhibited cytotoxicity and reactive oxygen species (ROS) production in human liver-derived HepG2 cells. Sulfuretin up-regulated the activity of the antioxidant enzyme heme oxygenase (HO)-1 via nuclear factor E2-related factor 2 (Nrf2) translocation into the nucleus and increased the promoter activity of the antioxidant response element (ARE). Moreover, sulfuretin exposure enhanced the phosphorylation of c-Jun <I>N</I>-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2), which are members of the mitogen-activated protein kinase (MAPK) family. Furthermore, cell treatment with a JNK inhibitor (SP600125) and ERK inhibitor (PD98059) reduced sulfuretin-induced HO-1 expression and decreased its protective effects. Taken together, these results suggest that the protective effect of sulfuretin against <I>t</I>-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways. Therefore, sulfuretin could be advantageous as a bioactive source for the prevention of oxidative injury.</P>