Chromatographic Enantiomer Separation of Diphenylalanine on Chiral Stationary Phases Derived from Chiral Crown Ethers

WonjaeLee,Chae-SunBaek,KooLee 대한화학회 2002 Bulletin of the Korean Chemical Society Vol.23 No.11

운동생리학 : 6주간의 Sling운동과 Medx운동이 만성요통환자의 요부근력 안정화에 미치는 영향

이원재(WonJaeLee) 한국체육학회 2005 한국체육학회지 Vol.44 No.5

The purpose of this study was to investigate the effect of Sling-exercise and Medx-training to low back pain patient's lumbar back strength stabilization.Subjects were 13 men, 11 women of low back pain patient, and were treated by Sling-exercise and Medx-training.The method was two training to 4times/week put in effect, so that total times was 40min. in the course of 6 weeks. And then lumbar back strength of angle were measured and the results were as follows.Lumbar back strength of men showed a significant different in the period. and both groups showed increased tendency. Especially, Sling-exercise group showed a higher than medx-training group.Lumbar back strength of women showed a significant different in the period. and both groups showed increased tendency. Especially, Sling-exercise group showed a higher than medx-training group. These results could suggest effective program as improvement of lumbar back strength to low back pain patient.

자연과학편 : 수부손상에 의한 groin flap 환자에게 조기 견관절 운동치료 프로그램 적용이 견관절 ROM 및 통증정도에 미치는 영향

이원재(WonJaeLee),주성범(SungBumJu),이선옥(SeonOkLee) 한국체육학회 2006 한국체육학회지 Vol.45 No.6

본 연구는 수부손상에 의한 groin flap환자에게 조기에 견관절 운동치료 프로그램을 적용하여 견관절 ROM과 통증정도에 미치는 영향을 살펴보는 것이다. 이를 위하여 수부손상환자 14명을 통제군 7명과 실험군 7명으로 나누었다. 통제군은 수부재활치료만을 실시하였고, 실험군은 수부재활치료와 더불어 견관절 운동치료 프로그램을 8주간 적용하여 견관절 ROM과 통증정도를 측정하여 비교 분석하였다. 견관절 ROM에서는 견관절 굴곡, 외전, 외회전 각도에서 견관절 운동치료군이 8주후에 통제군보다 유의하게 높게 나타났으며(p<0.05), 견관절 통증에서는 견관절 운동치료군통제군이 6주후와 8주후에 유의하게 낮게 나타났다.(p<0.05). 이처럼, 수부손상에 의한 groin flap 환자에게 조기 견관절 운동치료 프로그램 적용은 견관절 굴곡, 외전, 외회전 ROM 증가와 통증 감소에 도움을 주는 것으로 나타났다. The purpose of this study was to evaluate the effects of early exercise therapy program on shoulder ROM, pain degree in groin flap patients of hand injury. Subjects were divided in to 2 group(control group, experimental group) from 14 groin flap patients of band injury. The experimental group were treated with exercise therapy program for 8 weeks and the effects on shoulder ROM, pain degree have been evaluated. In range of motion of shoulder, flexion, abduction, external rotation of shoulder of experimental group increased significantly to eight weeks later than those of control group did. Pains of shoulder of experimental group decreased significantly six weeks and eight weeks later than that of control group did. In conclusion, early shoulder exercise therapy program for groin flap patients of hand injury will be effectively appeared to increasing of shoulder flexion, abduction, external ROM and decreasing of pain degree.

Focal Eosinophilic Necrosis of the Liver in Patients with Underlying Gastric or Colorectal Cancer:CT Differentiation from Metastasis

Hyun-JungJang,WonJaeLee,SoonJinLee,SeungHoonKim,HyoK.Lim,JaeHoonLim 대한영상의학회 2002 Korean Journal of Radiology Vol.3 No.4

Objective: To determine the helical CT findings which help differentiate between focal eosinophilic necrosis (FEN) of the liver and metastasis in patients with underlying gastric or colorectal cancer. Materials and Methods: In 21 patients with underlying gastric and colorectal cancer examined during a recent 18-month period, the presence of FEN (n=90) was proven at CT. The diagnosis was verified by biopsy in eight patients and by the transient nature of the findings related to peripheral eosinophilia (>10%) in the remainder. For comparison, 20 consecutive patients with pathologically proven hepatic metastasis from gastric or colorectal cancer (n=158) were selected. Single-phase helical CT images (7-mm collimation, pitch 1:1) were independently analyzed in a random order by two blinded readers. The parameters evaluated included the margin (depicted border, fuzzy), shape (spherical, non-spherical), attenuation (subtle hypoattenuation, hypoattenuation), and the presence or absence of rim enhancement. Results: FEN far more frequently showed a fuzzy margin (81%, 84%), subtle hypoattenuation (89%, 91%), and a non-spherical shape (84% for both readers) than metastasis, for which the respective findings were 6%, 22%; 20%, 39%; and 15%, 23%. Rim enhancement was seldom found in FEN (0%, 2%), but was recognized by both readers in 40% of metastases. For all parameters, the results were statistically significant (p < .01), and showed that both readers correctly differentiated FEN from metastasis in 78% of the patients (32/41). Interobserver agreement was, in addition, excellent (к= 0.66). Conclusion: When focal hepatic lesions with a fuzzy margin, non-spherical shape and subtle hypoattenuation without rim enhancement are found, the possibility of FEN should be considered even in patients with underlying gastrointestinal malignancy.

Design of a Single-Transistor-Type Ferroelectric Field Effect Transistor Memory

YilSukYang,In-kyuYou,WonJaeLee,ByoungGonYu,Kyong-IkCho 한국물리학회 2002 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.40 No.4

자연과학편 : 최대하운동 후 고온 및 저온 반신침수 적용이 생리적 변인 및 혈중 피로변인에 미치는 영향

김상수(SangSuKim),이원재(WonJaeLee),주성범(SungBumJu) 한국체육학회 2007 한국체육학회지 Vol.46 No.5

본 연구는 최대하운동 후 고온 및 저온 반신침수의 적용이 생리적 변인 및 혈중 피로변인에 미치는 영향을 살펴보는 것이다. 이를 위하여 고등부 조정선수들에게 로잉머신상에서 최대산소섭취량의 80%강도로 최대하운동을 적용시킨 후 각각 15분간의 고온반신침수(41-43℃)와 저온반신침수(14-16℃)를 적용시켜 심박수, 고막온도, 혈중젖산, 혈장 암모니아, 혈청 LDH, 혈청 CPK를 측정하였다. 생리적 변인 중 심박수와 고막온도의 변화에서는 저온반신침수의 적용이 회복기 심박수와 고막온도 감소에 도움이 되는 것으로 나타났으며, 혈중피로변인 중 혈중젖산 및 혈장암모니아의 변화에서는 고온반신침수와 저온반신침수의 적용이 회복기 혈중젖산 및 혈장 암모니아 감소에 도움을 되는 것으로 나타났으며, 혈청 CPK는 고온반신침수 적용에 따라, 회복처치후부터 안정시 혈청 CPK 수준까지 회복되는 효과를 나타냈다. 이처럼, 저온반신침수의 심박수 및 고막온도의 회복양상을 볼 수 있었으며, 실질적으로 운동피로의 회복측면에서 고온반신침수의 적용은 혈중젖산, 혈중 암모니아 및 혈청 CPK의 회복효과가 더욱 높은 것으로 나타나, 선수들의 최대하운동 후 운동피로 회복을 위한 방법으로 권장될 수 있을 것으로 생각된다. The purpose of this study was to evaluate the effects of hot water half-immersion or cold water half-immersion on physiological variable and blood fatigue variable after submaximal exercise. Subjects were performed rowing exercise of 80%VO₂max and then were treated half-immersion hot water or cold water half-immersion for 15 min and the effects on heart rate, eardrum temperature, blood lactic acid, plasma amonia, serum CPK and serum LDH have been evaluated. Cold water half-immersion effectively appeared to recovery heart rate and eardrum temperature. And hot water half-immersion effectively appeared to recovery blood lactic acid, plasma amonia, serum CPK. These results could suggest optimal recovery trial in submaximal exercise, as applying of hot water half-immersion showed the effective recovery program as the change of blood lactic acid, plasma amonia, serum CPK.

IGF-1 유전자 다형성과 농구운동 후 신체구성, 체력 및 성장지표 변화의 관련성

김기진(KiJinKim),이원재(WonJaeLee),이선장(SunJangLee),천우광(WooKwangCheon),안나영(NaYoungAhn),홍창배(ChangBaeHong) 한국체육학회 2011 한국체육학회지 Vol.50 No.2

초등학생의 농구운동 프로그램을 수행한 농구운동그룹과 일반적인 생활만을 경험한 통제그룹을 대상으로 3개월 전·후의 신체구성, 체력 및 성장지표 등의 변화양상을 분석하고, 이러한 변화양상이 성장관련 유전자의 다형성에 따라서 어떤 차이를 나타내는가를 비교하였다. 본 연구의 대상자는 초등학교에 재학 중인 학생 201명(남자 115명, 여자 86명)으로서, 농구운동그룹의 121명(남자 75명, 여자 46명)과 농구클럽에 참여하지 않은 통제그룹의 아동 80명(남자 40명, 여자 40명)을 구성하였다. IGF-1 유전자는 19 repeat(192 bp)가 41.3%로 가장 높은 빈도를 나타냈으며 남자는 19명(16.5%)은 19 CA repeat homozygous, 57명(49.6%)은 heterozygous, 39명(33.9%)은 19 CA repeat non-carriers에 해당하며, 여자는 16명(18.6%)은 19 CA repeat homozygous, 39명(45.3%)은 19 CA heterozygous, 31명(36.1%)은 19 CA repeat non-carriers로 나타났다. IGF-1 유전자 다형성에 따른 신체구성 및 체력의 대부분 항목에서 유의한 차이가 없었으며, 192/192 homozygous그룹의 골연령이 다소 높게 나타나 조기성장 경향을 나타냈으나 유의한 차이는 없었다. 따라서 IGF-1 및 성장호르몬 유전자는 아동들의 성장과정에서 신체구성 및 체력에 현저한 영향을 미치지 않는 것으로 나타났다. 또한 아동의 12주간 농구운동 효과는 신체구성에서는 현저한 차이는 없었으나 남녀 모두 근력 및 근지구력이 향상되는 것으로 나타났으며, IGF-1 유전자 다형성은 농구운동 시 신체구성 및 체력 변화의 차이에 현저한 영향을 미치지 않는 것으로 나타났다. The purpose of this study analyzed the comparisons of body composition, physical fitness, growth markers and 12-week basketball exercise intervention-mediate changes according to IGF-1 gene polymorphism in elementary school students. We studied elementary school students who were divided into 2 groups as a basketball exercise group (boy=75, girl= 46) and a control group (boy=40, girl=40). Subjects were measured on body composition, physical fitness, and growth markers. The genotype distribution of the IGF-1 gene polymorphism in entire subjects showed the highest percentage (41.3%) in 19 repeat(192 bp). The genotype distribution of the IGF-1 gene polymorphism showed 16.5% of 19 CA repeat homozygous, 49.6% of heterozygous, 33.9% of 19 CA repeat non-carriers in boy subjects, 18.6% of 19 CA repeat homozygous, 45.3% of 19 CA heterozygous, 36.1% of 19 CA repeat non-carriers in girl subjects. Body composition and physical fitness were no significant differences among groups of the IGF-1 gene polymorphism, although 192/192 homozygous group showed a relative high value of bone age. There were positive results in muscular strength and endurance after 12-week basketball exercise training in all groups. But we could not find the significant difference of 12-week basketball exercise intervention-mediate changes according to IGF-1 gene polymorphism in elementary school students.

Focal Hepatic Lesions: Evaluation with Contrast-Enhanced Gray-Scale Harmonic US

Hyun-JungJang,HyoK.Lim,WonJaeLee,SeongHyunKim,MinJuKim,DongilChoi,SoonJinLee,JaeHoonLim 대한영상의학회 2003 Korean Journal of Radiology Vol.4 No.2

Objective: To determine the findings of various focal hepatic lesions at contrast- enhanced gray-scale ultrasound (US) using a coded harmonic angio (CHA) technique and emphasizing lesion characterization. Materials and Methods: The study involved 95 patients with 105 focal hepatic lesions, namely 51 hepatocellular carcinomas (HCCs), 22 metastases, 22 hemangiomas, four cases of focal nodular hyperplasia (FNH), and six nontumorous nodules. After the injection of a microbubble contrast agent (SH U 508A), gray-scale harmonic US studies using a CHA technique were performed with a combination of continuous scanning to assess the intratumoral vasculature (vascular imaging) and interval-delay scanning to determine the sequential enhancement pattern (acoustic emission imaging). Each imaging pattern was categorized and analyzed. Results: At vascular imaging, 69% of HCCs (35/51) showed irregular branching vessels, while in 91% of metastases (20/22) a peripherally stippled pattern was observed. Intratumoral vessels were absent in 95% of hemangiomas (21/22) and all nontumorous lesions (6/6), while in 75% of FNHs (3/4) a spoke-wheel pattern was evident. At acoustic emission imaging, 71% of HCCs (36/51) showed heterogeneous enhancement and 86% (19/22) of metastases showed rim- or flame-like peripheral enhancement during the early phase, with washout occurring in all HCCs and metastases (100%, 73/73) during the late phase. In hemangiomas, enhancement was either peripheral and nodular (19/22, 86%) or persistent and homogeneous (3/22, 14%), and 75% of FNHs (3/4) became isoechoic during the late phase. Conclusion: At contrast-enhanced gray-scale US using a CHA technique, a period of continuous scanning depicted the intratumoral vasculature, and intervaldelay scanning demonstrated the sequential enhancement pattern. The characteristic findings of various focal hepatic lesions were thus determined.

Optimal Pulse Sequence for Ferumoxides-Enhanced MR Imaging Used in the Detection of Hepatocellular Carcinoma: A Comparative Study Using Seven Pulse Sequences

SeungHoonKim,DongilChoi,JaeHoonLim,WonJaeLee,Hyun-JungJang,HyoKeunLim,SoonJinLee,JaeMinCho,SeungKwonKim,GabChulKim 대한영상의학회 2002 Korean Journal of Radiology Vol.3 No.2

Objective: To identify the optimal pulse sequence for ferumoxides-enhanced magnetic resonance (MR) imaging in the detection of hepatocelluar carcinomas (HCCs). Materials and Methods: Sixteen patients with 25 HCCs underwent MR imaging following intravenous infusion of ferumoxides. All MR studies were performed on a 1.5-T MR system, using a phased-array coil. Ferumoxides (Feridex IV) at a dose of 15 mol/Kg was slowly infused intravenously, and axial images of seven sequences were obtained 30 minutes after the end of infusion. The MR protocol included fast spin-echo (FSE) with two echo times (TR3333 8571/TE18 and 90-117), singleshot FSE (SSFSE) with two echo times (TR /TE39 and 98), T2*-weighted gradient-recalled acquisition in the steady state (GRASS) (TR216/TE20), T2*-weighted fast multiplanar GRASS (FMPGR) (TR130/TE8.4 9.5), and T2*-weighted fast multiplanar spoiled GRASS (FMPSPGR) (TR130/TE8.4 9.5). Contrast-to-noise ratios (CNRs) of HCCs determined during the imaging sequences formed the basis of quantitative analysis, and images were qualitatively assessed in terms of lesion conspicuity and image artifacts. The diagnostic accuracy of all sequences was assessed using receiver operating characteristic (ROC) analysis. Results: Quantitative analysis revealed that the CNRs of T2*-weighted FMPGR and T2*-weighted FMPSPGR were significantly higher than those of the other sequences, while qualitative analysis showed that image artifacts were prominent at T2*-weighted GRASS imaging. Lesion conspicuity was statistically significantly less clear at SSFSE imaging. In term of lesion detection, T2*-weighted FMPGR, T2*- weighted FMPSPGR, and proton density FSE imaging were statistically superior to the others. Conclusion: T2*-weighted FMPGR, T2*- weighted FMPSPGR, and proton density FSE appear to be the optimal pulse sequences for ferumoxidesenhanced MR imaging in the detection of HCCs.

자연과학편 : 키네시오테이핑과 운동치료 프로그램의 복합적용이 요추 추간판 탈출증 수술환자의 요부신전근력과 통증정도에 미치는 영향

주성범(SungBumJu),이원재(WonJaeLee) 한국체육학회 2006 한국체육학회지 Vol.45 No.3

본 연구는 요추 추간판 탈출증 수술환자들에게 키네시오테이핑과 운동치료 프로그램의 복합적용에 따른 요부신전근력과 통증정도에 미치는 영향을 살펴보는 것이다. 이를 위하여 요추 추간판 탈출증 수술환자 15명을 통제군 7명과 실험군 8명으로 나누어 12주간의 적용 전, 후에 요부신전근력 및 통증정도를 측정하였다. 요부신전근력의 변화에서는 키네시오테이핑과 운동치료 프로그램 적용 그룹에서 요부굴곡각도( 0°, 12°, 24°, 36°, 48°, 60°, 72°)에서 적용 전에 비해 적용 후에 요부신전근력의 유의한 증가를 나타냈으며(p<.05), 통증정도의 변화에서는 키네시오테이핑과 운동치료 프로그램 복합적용 그룹에서 보행시 자유도를 제외한 13가지의 통증척도가 적용 전에 비해 적용 후에 유의한 감소를 나타냈다(p<.05). 이처럼, 요추 추간판 탈출증 수술환자들에게 키네시오테이핑과 운동치료 프로그램의 복합적용은 요부기능 향상 및 통증감소에 도움을 주는 것으로 나타났다. The purpose of this study is to evaluate the effects of kinesio taping and exercise therapy program on lumbar extension muscle strength, visual analogue scale in operation patients of lumbar disk herniation. Subjects was divided in to 2 group(control group, kinesio taping and exercise therapy program group) from 15 operation patients of lumbar disk herniation. The patients were treated with kinesio taping and exercise therapy program for 12 weeks and the effects on lumbar extension muscle strength, visual analogue scale have been evaluated. The kinesio taping and exercise therapy program group was significantly increased lumbar extension muscle strength( 0°, 12°, 24°, 36°, 48°, 60°, 72°) and there were significantly decreased all visual analogue scale factor except walking freedom after 12weeks. To conclude, Applying of kinesio taping and exercise therapy program for operation patients of lumbar disk herniation will be effectively appeared to improvement of lumbar function and decreasing of pain.