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Prognostic significance of lymphovascular invasion in sporadic colorectal cancer.
Lim, Seok-Byung,Yu, Chang Sik,Jang, Se Jin,Kim, Tae Won,Kim, Jong Hoon,Kim, Jin Cheon Lippincott [etc.] ; Lippincott WilliamsWilkins 2010 Diseases of the colon and rectum Vol.53 No.4
<P>PURPOSE: It remains unclear whether lymphovascular invasion marks a poor prognosis for patients with sporadic colorectal cancers. Here, we analyzed the association between lymphovascular invasion and the clinicopathological features and prognosis of sporadic colorectal cancer patients. METHODS: The clinicopathological features and prognosis of 2417 patients with sporadic primary colorectal cancer who underwent an operation at the Asan Medical Center between January 1998 and December 2002 were examined. The patients' clinicopathological parameters and follow-up and survival data were obtained from a prospectively collected database. RESULTS: Of the 2417 patients, a lymphovascular invasion-positive tumor was detected in 610 (25.2%). Compared with patients with lymphovascular invasion-negative tumors those with lymphovascular invasion-positive tumors were older (P < .001) and had higher preoperative serum carcinoembryonic antigen levels (P = .011). Their tumors were also more likely to be poorly differentiated (P < .001) and more advanced in terms of T and N categories (P < .001 and P < .001, respectively). The lymphovascular invasion-positive tumors were also more likely to have metastasized systemically (P < .001). Although lymphovascular invasion-positive and lymphovascular invasion-negative tumors metastasized equally frequently to the liver, lung, peritoneum, and bone, lymphovascular invasion-positive tumors metastasized to systemic lymph nodes more often (P < .001). These tumors also recurred at systemic lymph nodes after curative intent surgery more often (P = .007). Lymphovascular invasion-positive status was an independent unfavorable prognostic factor for the 5-year overall and 5-year disease-free survival of patients with sporadic colorectal cancer (P < .001 and P < .001, respectively). CONCLUSION: Lymphovascular invasion-positive status could be used to identify patients with sporadic primary colorectal cancer with aggressive tumors and as a factor that independently indicates an unfavorable prognosis.</P>
Evaluation of Genetic Diversity among Korean Wheat Using RAPD and ISSR Analysis
Won Cheol Yim,Moon Seok Kang,Young Up Kwon,Cheol Seong Jang,Yong Weon Seo,Sung Don Lim,Kyung Hee Kim,Jun Cheol Moon,Sang Kyu Lee,Byung Moo Lee 한국육종학회 2007 한국육종학회지 Vol.39 No.3
The genetic diversity was evaluated using RAPD and ISSR among natural populations and Korean wheat cultivars (Triticum aestivum). Understanding the genetic diversity of putative parental and wild stocks would be useful in wheat breeding programs. Ninety three populations were evaluated with fifty RAPD and three ISSR primers. A total of 185 RAPD and ISSR polymorphism were produced. These markers were considered to estimate the genetic distance among accessions. The genetic similarity ranged from 0.41 to 0.86. The dendrogram were constructed by using the UPGMA clustering algorithm based on genetic similarity. The genetic diversity within and among accession was assessed through Principal Component Analysis (PCA) for statistics analysis. In cluster analysis, four groups were clustered and 17 accessions were not clustered. The PCA was corresponded well to the result. This study provides basic information about the genetic relationships for breeding purposes.
Elastic resistance change and action potential generation of non-faradaic Pt/TiO2/Pt capacitors.
Lim, Hyungkwang,Jang, Ho Won,Lee, Doh-Kwon,Kim, Inho,Hwang, Cheol Seong,Jeong, Doo Seok RSC Pub 2013 Nanoscale Vol.5 No.14
<P>Electric current in the mixed ionic-electronic conductor TiO2 is hysteretic, i.e. history-dependent, and its use is versatile in electronic devices. Nowadays, biologically inspired, analogue-type computing systems, known as neuromorphic systems, are being actively investigated owing to their new and intriguing physical concepts. The realization of artificial synapses is important for constructing neuromorphic systems. In mammalians' brains, the plasticity of synapses between neighbouring nerve cells arises from action potential firing. Emulating action potential firing via inorganic systems has therefore become important in neuromorphic engineering. In this work, the current-voltage hysteresis of TiO2-based non-faradaic capacitors is investigated to primarily focus on the correlation between the blocking contact and the elasticity, i.e. non-plasticity, of the capacitors' resistance change, in experimental and theoretical methods. The similarity between the action potential firing behaviour in nerve cells and the elasticity of the non-faradaic capacitors is addressed.</P>
Won, Hyung-Sun,Han, Seung-Ho,Oh, Chang-Seok,Chung, In-Hyuk,Kim, Seung Min,Lim, So Young Journal of Neurosurgery Publishing Group 2011 Journal of Neurosurgery Vol.114 No.6
<B>Object</B><P>The authors have observed that the ulnar nerve (UN) passes through the medial intermuscular septum (MIMS) into the posterior compartment of the upper arm in more complicated patterns than those described in anatomy textbooks. Given that these unreported patterns might be related to the idiopathic UN entrapment at the midarm, this study focused on the relationship between the MIMS and the UN.</P><B>Methods</B><P>One hundred upper arms were dissected. The site at which the UN pierced the MIMS was analyzed and measured from the medial epicondyle.</P><B>Results</B><P>The relationship between the MIMS and the UN could be classified into 3 types according to whether the nerve pierced the MIMS and whether it ran through a fibrous tunnel within the septum. The UN pierced the MIMS in the middle third of the upper arm.</P><B>Conclusions</B><P>The results of this study are expected to further understanding of the relationship between the MIMS and the UN. They could also be helpful for surgeons aiming to relieve UN entrapment at the midarm, especially in nerve lesions of idiopathic origin.</P>
Lim, Youn-Mook,Kim, Bo Hae,Kim, Hee-Bok,Park, EunJi,Park, Seok-Won,Park, Jong-Seok,Choi, Se In,Kwon, Tack-Kyun,Kwon, Seong Keun Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>This study explored a novel strategy to restore the vocal gap by using cross-linked <I>β</I>-glucan hydrogel by <I>γ</I>-irradiation. An aqueous solution of 5 wt% <I>β</I>-glucan was prepared and cross-linked using <SUP>60</SUP>Co <I>γ</I> irradiation. Ten nude mice were injected with 0.8 mL of irradiated <I>β</I>-glucan on the left back and the same volume of nonirradiated <I>β</I>-glucan on the right back for comparison. The mice were sacrificed at 1 and 2 weeks after injection and histological evaluations were performed. Irradiated <I>β</I>-glucan demonstrated a significantly larger volume than nonirradiated <I>β</I>-glucan in the back of nude mice with less inflammatory reaction. After unilateral recurrent laryngeal nerve section in New Zealand White rabbits, irradiated and nonirradiated <I>β</I>-glucan were injected into paralyzed vocal folds. Irradiated <I>β</I>-glucan remained at the paralyzed vocal fold without definite inflammatory signs on endoscopy. High-speed recordings of vocal fold vibration showed decreased vocal gap in irradiated group compared to nonirradiated group. Histologically, the laryngeal epithelium and lamina propria remained intact, without inflammatory cell infiltration. Our newly developed injection material, irradiated <I>β</I>-glucan, showed excellent biocompatibility and remained longer than nonirradiated <I>β</I>-glucan<I> in vivo</I>, suggesting irradiated hydrogels as a new therapeutic approach that may be useful for the long-term treatment of vocal fold palsy.</P>
The effect of overlaying titanium mesh with collagen membrane for ridge preservation
Lim, Hyun-Chang,Lee, Jung-Seok,Choi, Seong-Ho,Jung, Ui-Won Korean Academy of Periodontology 2015 Journal of Periodontal & Implant Science Vol.45 No.4
Purpose: The aim of this study was to determine the effect of overlaying titanium mesh (TM) with an adjunctive collagen membrane (CM) for preserving the buccal bone when used in association with immediate implant placement in dogs. Methods: Immediate implant placements were performed in the mesial sockets of the third premolars of five dogs. At one site the TM was attached to the fixture with the aid of its own stabilizers and then covered by a CM (CM group), while the contralateral site received only TM (TM group). Biopsy specimens were retrieved for histologic and histomorphometric analyses after 16 weeks. Results: All samples exhibited pronounced buccal bone resorption, and a high rate of TM exposure was noted (in three and four cases of the five samples in each of the TM and CM groups, respectively). A dense fibrous tissue with little vascularity or cellularity had infiltrated through the pores of the TM irrespective of the presence of a CM. The distances between the fixture platform and the first bone-implant contact and the bone crest did not differ significantly between the TM and CM groups. Conclusions: Our study suggests that the additional use of a CM over TM does not offer added benefit for mucosal healing and buccal bone preservation.