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강길원,박형근,김창엽,김용익,하범만,Kang, Gil-Won,Park, Hyoung-Keun,Kim, Chang-Yup,Kim, Yong-Ik,Ha, Beom-Man 대한예방의학회 2000 예방의학회지 Vol.33 No.4
Objectives : To evaluate the impacts of the DRG payment system on the behavior of medical insurance claimants. Specifically, we evaluated the case-mix index, the numbers of diagnosis and procedure codes utilized, and the corresponding rate of diagnosis codes before, during and after implementation of the DRG payment system. Methods : In order to evaluate the case-mix index, the number of diagnosis and procedure codes utilized, we used medical insurance claim data from all medical facilities that participated in the DRG-based Prospective Payment Demonstration Program. This medical insurance claim data consisted of both pre-demonstration program data (fee-for-service, from November, 1998 to January, 1999) and post-demonstration program data (DRG-based Prospective Payment, from February, 1999 to April, 1999). And in order to evaluate the corresponding rate of diagnosis codes utilized, we reviewed 820 medical records from 20 medical institutes that were selected by random sampling methods. Results : The case-mix index rate decreased after the DRG-based Prospective Payment Demonstration Program was introduced. The average numbers of different claim diagnosis codes used decreased (new DRGs from 2.22 to 1.24, and previous DRGs from 1.69 to 1.21), as did the average number of claim procedure codes used (new DRGs from 3.02 to 2.16, and previous DRGs from 2.97 to 2.43). With respect to the time of participation in the program, the change in number of claim procedure codes was significant, but the change in number of claim diagnosis codes was not. The corresponding rate of claim diagnosis codes increased (from 57.5% to 82.6%), as did the exclusion rate of claim diagnosis codes (from 16.5% to 25.1%). Conclusions : After the implementation of the DRG payment system, the corresponding rate of insurance claim codes and the corresponding exclusion rate of claim diagnosis codes both increased, because the inducement system for entering the codes for claim review was changed.
Influence of Growth Temperature on the Characteristics of Single-Junction p—i—n InGaP Solar Cells
Jung, Sang Hyun,Kim, Youngjo,Kim, Chang Zoo,Jun, Dong-Hwan,Kim, Kangho,Shin, Hyun-Beom,Choi, JeHyuk,Park, Won-Kyu,Lee, Jaejin,Kang, Ho Kwan American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.4
<P>Single-junction p-i-n InGaP solar cells are grown at various temperatures from 620 to 700 degrees C by low pressure metalorganic chemical vapor deposition on GaAs (001) substrates. The short circuit current density of the p-i-n InGaP solar cells increases by up to 38.8% when the growth temperature is reduced from 700 to 620 degrees C, while the open circuit voltage and fill factor show relatively small changes. The external quantum efficiency, especially, in the wavelength regime below 500 nm, is improved for the p-i-n InGaP solar cells grown at lower temperatures. The improvement might be attributed to the reduced absorption loss of the photons in the n-InGaP emitter region. The highest conversion efficiency of 11.01% is attributed from the p-i-n InGaP solar cell grown at 640 degrees C. Electron mobility and concentration of undoped InGaP layers are investigated as a function of the growth temperature and correlated with the p-i-n InGaP solar cell performance.</P>
전하룡(Ha-Ryong Jeon),김종원(Jong-Won Kim),권호범(Ho-Beom Kwon),이동환(Dong-Hwan Lee),홍종락(Jong-Rak Hong),김창수(Chang-Soo Kim) 대한구강악안면외과학회 2006 대한구강악안면외과학회지 Vol.32 No.3
Purpose: This study presents radiographic and laboratory analysis and comparison of bone resorption rate of grafted endochondral bone and intramembranous bone on the aspect of height and volumetric change. Patients and Methods: 18 partially edentulous patients who needed alveolar ridge augmentation for implant placement during the years 2002 to 2004 were selected for this study. Group A consisted of 5 males & 3 females who were treated with intraoral(intramembranous) bone and Group B consisted of 8 males & 2 females who were treated with iliac(endochondral) bone. Non-standard periapical X-ray was taken at day 1, 2 month, 4 months, 8 months after the surgery. Resorption rate of grafted bone were measured on these X-rays and compared. Also we calculated volume of grafted bone with models which was fabricated at 1.5 months, 6 months. Results: There was bone resorption in both groups. Group B showed more bone resorption than Group A. In Group A, the resorption rate according to the radiographic measurements was 9.81 %, and resorption rate according to volumetric measurement was 16.5 %. In group B, the resorption rate according to the radiographic measurements was 15.9 %, and resorption rate according to volumetric measurement was 30.6 %. Significant difference is on radiographic resorption of post-op 2, 4, 8 months on two groups (P < 0.05). Also significant difference is on volume resorption on two groups (P < 0.05) Conclusion: We found that more bone resorption occurred with iliac(endochondral) bone and when we use intraoral bone, that bone can maintain their vitality for alveolar ridge augmentation.
Isolated Right Pulmonary Artery Hypoplasia with Retrograde Blood Flow in a 68-Year Old Man
Chang, You-Jin,Ra, Seung-Won,Chae, Eun-Jin,Seo, Joon-Beom,Kim, Won-Young,Na, Shin,Kim, Joo-Hee,Park, Tai-Sun,Park, Soo-Kyung,Park, Seong-Joon,Lee, Tae-Hoon,Ahn, Young-Chel,Lee, Sang-Do The Korean Academy of Tuberculosis and Respiratory 2011 Tuberculosis and Respiratory Diseases Vol.71 No.2
Unilateral pulmonary artery hypoplasia (UPAH) is a rare disease in adults and is frequently accompanied by a congenital cardiac anomaly at a young age. The diagnosis is usually based on computed tomography (CT), angiography, and magnetic resonance imaging (MRI). However, no reports are available on retrograde flow in patients with UPAH. We describe a 68-year-old man with isolated UPAH and retrograde blood flow. He was admitted for dyspnea on exertion for the past 23 years. His diagnosis was delayed, as his symptoms and signs mimicked his underlying pulmonary diseases, such as emphysema and previous tuberculous pleurisy sequelae. A discrepancy was detected between the results of a ventilation-perfusion scan and the CT image. This was resolved by MRI, which showed retrograde blood flow from the right to the left pulmonary artery. Using MRI, we diagnosed this patient with isolated pulmonary artery hypoplasia and retrograde flow.
( Sang Il Choi ),( Joong-won Park ),( Bo Hyun Kim ),( Ju Hee Lee ),( Seung Duk Lee ),( In Joon Lee ),( Tae Hyun Kim ),( Seong Hoon Kim ),( Young Hwan Koh ),( Hyun Beom Kim ),( Eun Kyung Hong ),( Chang 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: In South Korea, an endemic area of hepatitis B virus (HBV), the incidence and mortality of HCC is gradually decreasing by HBV vaccination, antiviral treatment, early tumor detection, improved treatment options, and evidence-based guidelines. This study investigated the changes over time in the baseline characteristics and clinical outcomes of HCC patients at a single center. Methods: Patients initially diagnosed with and treated for HCC at the National Cancer Center between 2000 and 2015 (n=4291) were followed-up until February 2017. Difference in patient characteristics and outcomes were compared in patients diagnosed in 2000-2004 (n=1157), 2005-2009 (n=1678), and 2010-2015 (n=1456). Results: The median age of the patient cohort was 57 years (range 13-98) years, and most were male (3502, 81.6%). HBV infection was the most common etiology (74.7%). The percentage of patients with Child class A (69.1%, 79.9%, and 87.1%, respectively) and BCLC stage 0 (4.1%, 5.2%, and 9.8%, respectively) increased significantly over time. Median overall survival also increased significantly over time, from 14.4 months (95% confidence interval [CI] 12.0-16.8 months) in 2000-2004, to 22.9 months (95% CI, 20.3-25.5 months) in 2005-2009, to 53.6 months (95% CI, 45.7- 61.5 months) in 2010-2015 (p<0.001). OS of patients with modified UICC stage IV (3.6 vs. 4.7 vs 6.1 months, p<0.001) and with HBV etiology (12.7 vs 20.4 vs 64.5 months, p<0.001) was observed in patients diagnosed in 2000-2004, 2005-2009 and 2010-2015, respectively. Conclusions: Survival of patients with HCC has improved significantly over time in a single center in South Korea. Analysis is ongoing to determine the causes of the improved outcomes.
Chang, Jong Wook,Kang, Un-Beom,Kim, Dong Hyun,Yi, Jae Kyo,Lee, Jong Won,Noh, Dong-Young,Lee, Cheolju,Yu, Myeong-Hee Wiley - VCH Verlag GmbH Co. KGaA 2008 PROTEOMICS CLINICAL APPLICATIONS Vol.2 No.1
<P>Comparative proteome analysis was performed on the cultured media of human nontumor and malignant breast cell lines, Hs578Bst and Hs578T, respectively, in search of a serological biomarker(s) for breast cancer. Proteins in the conditioned media were separated by 2-D PAGE and then visualized by silver-staining. Eight proteins changed differentially by more than two-fold were identified by MALDI-TOF/TOF MS. Among the proteins identified, the terminal laminin-like globular (LG3) domain of endorepellin, which was recently reported as an antiangiogenesis factor, was decreased in the cancer cell line. We confirmed the bone morphogenic protein-1 (BMP-1) mediated cleavage site on the N-terminus of endorepellin LG3 fragment. This finding suggests that the LG3 fragment is specifically released by a BMP-1 driven limited proteolytic process. The protein was also detected in plasma by Western blot analysis and selected reaction monitoring (SRM). The plasma level of the endorepellin LG3 fragment was significantly lower in breast cancer patients compared to healthy donors (p?=?0.017; n?=?12). The LG3 protein concentration in the control plasma was measured at approximately 3.7?pmol/mL compared to 1.8?pmol/mL in plasma from the cancer patients. We suggest that these results support the potential use of the endorepellin LG3 fragment as a new serological biomarker for breast cancer.</P>
Chang Seok Ko,Kyu Min Kim,Jong Won Lee,Han Shin Lee,Sae Byul Lee,Guiyun Sohn,Jisun Kim,Hee Jeong Kim,Il Yong Chung,Beom Seok Ko,Byung Ho Son,Seung Do Ahn,Sung-Bae Kim,Hak Hee Kim,Sei Hyun Ahn 한국유방암학회 2018 Journal of Breast Disease Vol.6 No.2
Purpose: This study aimed to determine whether clinicopathological factors are potentially associated with successful breast-conserving surgery (BCS) after neoadjuvant chemotherapy (NAC) and develop a nomogram for predicting successful BCS candidates, focusing on those who are diagnosed with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative tumors during the pre- NAC period. Methods: The training cohort included 239 patients with an HR-positive, HER2-negative tumor (≥3 cm), and all of these patients had received NAC. Patients were excluded if they met any of the following criteria: diffuse, suspicious, malignant microcalcification (extent >4 cm); multicentric or multifocal breast cancer; inflammatory breast cancer; distant metastases at the time of diagnosis; excisional biopsy prior to NAC; and bilateral breast cancer. Multivariate logistic regression analysis was conducted to evaluate the possible predictors of BCS eligibility after NAC, and the regression model was used to develop the predicting nomogram. This nomogram was built using the training cohort (n=239) and was later validated with an independent validation cohort (n=123). Results: Small tumor size (p<0.001) at initial diagnosis, long distance from the nipple (p=0.002), high body mass index (p=0.001), and weak positivity for progesterone receptor (p=0.037) were found to be four independent predictors of an increased probability of BCS after NAC; further, these variables were used as covariates in developing the nomogram. For the training and validation cohorts, the areas under the receiver operating characteristic curve were 0.833 and 0.786, respectively; these values demonstrate the potential predictive power of this nomogram. Conclusion: This study established a new nomogram to predict successful BCS in patients with HR-positive, HER2-negative breast cancer. Given that chemotherapy is an option with unreliable outcomes for this subtype, this nomogram may be used to select patients for NAC followed by successful BCS.