Session F : Eukaryotic Gene Structure and Expression : RANDOM SEQUENCING OF HUMAN THYMUS cDNAs

Weon Kyung Cho,Dong Su Park,Seung Weon Jin,Hye Jeong Ahn,Jeong Hwa Kim,Kyu Tae Kim,U - Ik Sohn 생화학분자생물학회(구 한국생화학분자생물학회) 1993 추계학술대회집 Vol.- No.-

동영상 복사본 검출을 위한 시공간 정호를 이용한 동영상 서명

조익환(Ik-Hwan Cho),오원근(Weon-Geun Oh),정동석(Dong-Seok Jeong) 한국HCI학회 2008 한국HCI학회 학술대회 Vol.2008 No.2

본 논문에서는 동영상 복사본 검출을 위해 시공간 정보를 이용한 새로운 동영상 서명 방법을 제안한다. 제안된 동영상 복사본 검출 방법은 각 키프레임에 대하여 동심원 구획 방법에 기반을 두고 있다. 우선 입력 동영상으로부터 일정한 간격으로 시간적 이중 선형 보간법을 이용하여 키프레임을 추출하고 각 프레임은 동심원 형태로 구획된다. 구획된 세부영역에 대하여 상대적인 관계를 이용하여 평균 픽셀값, 평균 픽셀값의 차분값, 대칭적 차분값, 원형 차분값 분포의 4 가지 특징 분포를 추출한다. 최종적으로 이 특징 분포들은 간단한 해시 함수를 이용하여 이진 수열 형태로 변형되고 순서대로 병합된다. 제안된 동영상 서명에 대한 유사도 거리는 간단한 해밍 거리를 이용하여 계산되고 따라서 매우 빠른 정합 속도를 보인다. 실험 결과로부터 제안된 방법이 다양한 변형에 대하여 평균 97.4%의 높은 검출 성공률을 보이는 것을 알 수 있다. 그러므로 제안된 방법이 동영상 복사본 검출분야에서 폭넓게 사용될 수 있을 것으로 기대된다. This paper proposes new video signature using spatio-temporal information for copy detection. The proposed video copy detection method is based on concentric circle partitioning method for each key frame. Firstly, key frames are extracted from whole video using temporal bilinear interpolation periodically and each frame is partitioned as a shape of concentric circle. For the partitioned sub-regions, 4 feature distributions of average intensity, its difference, symmetric difference and circular difference distributions are obtained by using the relation between the sub-regions. Finally these feature distributions are converted into binary signature by using simple hash function and merged together. For the proposed video signature, the similarity distance is calculated by simple Hamming distance so that its matching speed is very fast. From experiment results, the proposed method shows high detection success ratio of average 97.4% for various modifications. Therefore it is expected that the proposed method can be utilized for video copy detection widely.

2004~2006년 대한해협 동쪽을 통과한 태풍들에 의한 폭풍파 관측

정원무(Jeong, Weon Mu),김상익(Kim, Sang Ik),백원대(Baek, Won Dae),오상호(Oh, Sang-Ho) 한국해안해양공학회 2014 한국해안해양공학회 논문집 Vol.26 No.2

최근 우리나라에는 거의 매년 대형 태풍이 내습하였으며 이로 인해 직 간접적으로 많은 피해가 발생하였다. 그러나 태풍의 내습 시 태풍의 외해 진입경로에서 파랑 및 바람자료를 확보한 사례는 매우 드물며 이로 인해 태풍파 모델링의 보정 및 검증자료 확보에 어려움을 겪고 있는 실정이다. 본 논문은 기상청과 한국해양과학기술원에서 2004~2006년에 내습한 태풍 송다, 나비, 산산으로 인한 폭풍파들을 관측한 기록들을 종합하여 제공함으로써 태풍파 수치모델링 관련 연구자들에게 도움이 되도록 하였다. 태풍 나비와 산산의 진행경로가 대한해협보다 동쪽이었음에도 불구하고 거제도 동쪽에 위치한 남형제도에서 유의파고 8.3 m가 관측되었으며, 특히 영일만방파제 전면 1.4 km 지점에서는 두 태풍 모두 기록적인 유의파고 12.2 m가 관측되었다. 한편, 거제도의 해양기상부이와 남형제도의 파향 파고계로 취득된 자료들의 비교 결과 최대파고는 유사하였으나 유의파고는 상당한 차이를 나타냈다. In recent years, strong typhoons have passed South Korea almost every year and severe damages were incurred directly and indirectly. However, instances where wave and wind data were procured from the offshore approach path of the typhoon are very rare and thus researchers are experiencing difficulties in obtaining calibration and verification data of typhoon-generated wave modeling. This paper provides a synthesis of records of observations by the Korea Meteorological Administration and Korea Institute of Ocean Science and Technology on storm waves generated by the typhoons SONGDA, NABI, and SHANSHAN that passed from 2004 to 2006 in order to help researchers interested in typhoon-generated wave numerical modeling. Although the trajectories of typhoon NABI and SHANSHAN were east of the Korea Strait, a significant wave height of 8.3 m was measured at Namhyeongjedo located east of Geojedo. Moreover, an unprecedented significant wave height of 12.2 m was measured for both typhoons at a station 1.4 km away from Yeongil Bay breakwater. Meanwhile, a comparative analysis of data obtained with a ocean data buoy at Geojedo and a Directional Waverider at Namhyeongjedo showed maximum wave heights that were similar but considerably different significant wave heights.

동해 연안 파력 부존량의 시간적 및 공간적인 변동 양상

정원무(Jeong, Weon Mu),조홍연(Cho, Hongyeon),오상호(Oh, Sang Ho),김상익(Kim, Sang Ik) 한국해안해양공학회 2013 한국해안해양공학회 논문집 Vol.25 No.5

본 연구에서는 동해 연안의 9개소에서 관측된 파랑 자료를 사용하여 파력 부존량을 평가하였으며 기존의 연구 결과와 비교하였다. 동해 연안에서는 파력 부존량의 계절 변화가 동계 6.4 kW/m, 하계 1.2 kW/m 정도로 공간적인 변화인 2.5~4.3 kW/m보다 크게 나타나고 있으며, 거의 대부분의 정점에서 하계 6~7월의 파력이 가장 작게 나타났다. 연 평균 파력 부존량 추정치는 동해 중부 해역에 위치하고 있는 묵호와 죽변 지점에서 4.3 kW/m 정도로 가장 크게 나타났으며, 진하 지점에서 2.5 kW/m로 가장 작게 나타났다. 또한 파력 부존량의 분포도 기존의 후측자료를 이용하여 제시된 남쪽에서 북쪽 방향으로의 감소 경향과는 달리 중부해역에서 가장 크고, 중부해역을 기준으로 남쪽, 북쪽 방향으로 모두 감소하는 경향을 보이는 것으로 파악되었다. In this study, the wave energy potential (WEP) was evaluated using the wave data measured at nine stations along the Korean east coast and compared with the results of previous studies. Along the Korean east coast, seasonal variations in the WEP were around 6.4 kW/m in winter and 1.2 kW/m in summer, greater than spatial variations of 2.5~4.3 kW/m. In most stations, the wave power during June to July were shown to be smallest. The estimated annual average WEP was greatest in the Mukho and Jukbyeon stations located in the middle of the Korean east coast at around 4.3 kW/m, and smallest in the Jinha station at around 2.5 kW/m. The results found using the previous hindcast data showed WEP having a tendency to decrease from south to north. However, in this study, the WEP showed a tendency of being greatest in the middle of the Korean east coast and decreasing in both north and south directions.

현장관측을 통한 이안소파잠제의 중력파 및 중력외파 저감효과 검토

정원무(Weon-Mu Jeong),백종대(Jong-Dai Back),최혁진(Hyukjin Choi),김상익(Sang-Ik Kim) 한국해안해양공학회 2018 한국해안해양공학회 논문집 Vol.30 No.2

본 연구는 속초시 영랑동 해안에 설치된 이안소파잠제의 중력파 및 중력외파 저감효과를 검토하기 위하여 잠제 전면(W0)과 후면(W1, W2)에서 현장관측을 수행하여 연속적인 파랑 자료를 분석하였다. 잠제에 의한 파고전달률(Kt)은 단주기파(중력파)와 중력외파로 구분하여 파랑에너지 저감 효과분석을 수행하였으며, 설계 시 적용된 파고저감률과 비교·분석하였다. 잠제 전면(W0)에서 2.0 m 이상의 유의파고가 내습할 경우, 단주기파는 남측 1번 잠제(W1) 배후 파고는 약 65% 저감되고, 2번 잠제 배후(W2) 파고는 약 59% 저감되는 것으로 나타나 잠제가 어느 정도 성능을 유지하고 있는 것으로 평가되었으나, 실해역에 설치된 잠제의 마루수심이 설계와 달라 파고저감 효과는 설계 시 계획에 비해서 다소 떨어지는 것으로 분석되었다. 중력외파는 1번 잠제 배후(W1)와 2번 잠제 배후(W2)에서 파고전달률(Kt)이 2.11과 1.71로 증폭되는 것으로 분석되었으며, 2번 잠제 배후(W2) 파고가 1번 잠제 배후(W1) 파고에 비해서 작은 것으로 나타났다. This study was conducted to observe the effects of gravity and infra-gravity wave of detached submerged breakwater in the coast of Yeongnang-dong, Sokcho, as analyzing continuous wave data by performing field observations on the front area (W0) and rear area (W1, W2). Wave transmission coefficient (Kt) of submerged breakwater was analyzed in two parts, short-period wave (gravity wave) and infra-gravity wave. The wave energy reduction effect was analyzed and compared with the value of the design. In case of above wave height 2.0 m at the front area (W0) of the submerged breakwater, the short-period wave height at point W1 is reduced by about 65% and the short-period wave height at point W2 is reduced by about 59%. The depth of crest of submerged breakwater conducted in a sea area differs from the design, and the wave energy reduction effect is analyzed to be smaller than the design plan. The infra-gravity waves were amplified to 2.11 and 1.71 at the W1 and W2 points, respectively, and the wave height at W2 point was smaller than that at W1 point.

Genomic landscape of ovarian clear cell carcinoma via whole exome sequencing

Kim, Se Ik,Lee, Ji Won,Lee, Maria,Kim, Hee Seung,Chung, Hyun Hoon,Kim, Jae-Weon,Park, Noh Hyun,Song, Yong-Sang,Seo, Jeong-Sun Elsevier 2018 Gynecologic oncology Vol.148 No.2

<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>To analyze whole exome sequencing (WES) data on ovarian clear cell carcinoma (OCCC) in Korean patients via the technique of next generation sequencing (NGS). Genomic profiles were compared between endometriosis-associated OCCC (EMS-OCCC) and Non-EMS-OCCC.</P> <P><B>Methods</B></P> <P>We used serum samples and cancer tissues, stored at the <ce:grant-sponsor id='gts0005' sponsor-id='https://doi.org/10.13039/501100004332' xlink:type='simple' xlink:role='http://www.elsevier.com/xml/linking-roles/grant-sponsor'>Seoul National University Hospital</ce:grant-sponsor> Human Biobank, that were initially collected from women diagnosed with OCCC between 2012 and 2016. In total, 15 patients were enrolled: 5 with pathologically confirmed EMS-OCCC and 10 with Non-EMS-OCCC. We performed NGS WES on 15 fresh frozen OCCC tissues and matched serum samples, enabling comprehensive genomic characterization of OCCC.</P> <P><B>Results</B></P> <P>OCCC was characterized by complex genomic alterations, with a median of 178 exonic mutations (range, 111-25,798) and a median of 343 somatic copy number variations (range, 43-1,820) per tumor sample. In all, 54 somatic mutations were discovered across 14 genes, including <I>PIK3CA</I> (40%), <I>ARID1A</I> (40%), and <I>KRAS</I> (20%) in the 15 Korean OCCCs. Copy number gains in <I>NTRK1</I> (33%), <I>MYC</I> (40%), and <I>GNAS</I> (47%) and copy number losses in <I>TET2</I> (73%), <I>TSC1</I> (67%), <I>BRCA2</I> (60%), and <I>SMAD4</I> (47%) were frequent. The significantly altered pathways were associated with proliferation and survival (including the PI3K/AKT, TP53, and ERBB2 pathways) in 87% of OCCCs and with chromatin remodeling in 47% of OCCCs. No significant differences in frequencies of genetic alterations were detected between EMS-OCCC and Non-EMS-OCCC groups.</P> <P><B>Conclusion</B></P> <P>We successfully characterized the genomic landscape of 15 Korean patients with OCCC. We identified potential therapeutic targets for the treatment of this malignancy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 14 genes, including PIK3CA, ARID1A and KRAS, were mutated in multiple Korean OCCCs. </LI> <LI> 53 somatic mutations (27 novel) were identified in fresh Korean OCCC tissue. </LI> <LI> Genomic landscape (somatic mutations and CNVs) expands our understanding of OCCCs. </LI> <LI> Genetic alteration frequencies were similar in OCCCs with or without endometriosis. </LI> </UL> </P>

우리나라 동해안 너울성 고파의 발생원인 분석

오상호(Oh, Sang-Ho),정원무(Jeong, Weon-Mu),이동영(Lee, Dong-Young),김상익(Kim, Sang-Ik) 한국해안해양공학회 2010 한국해안해양공학회 논문집 Vol.22 No.2

최근 우리나라 동해안에서 겨울철에 빈번하게 발생하는 너울성 고파의 특성을 파랑 관측자료 및 기상자료를 이용하여 분석하였다. 동해안 너울성 고파는 중국 내륙에서 발생한 온대성 저기압이 동해상으로 진출하면서 중심기압이 낮아지고, 그 주변으로 강한 기압골을 형성하면서 동해상에 강한 북동풍 계열의 바람이 지속적으로 붊에 따라 발생하게 됨을 다양한 자료 분석 결과를 토대로 입증하였다. 최근 동해안에 큰 피해를 입혔던 너울성 고파 중에서 2005년 10월 및 2006년 10월에 내습한 너울성 고파는 풍파의 특성이 지배적이었던 반면, 2008년 2월의 너울성 고파는 풍파에 의해 1차적으로 파고가 상승한 후 주기가 더 긴 너울에 의해서 다시 2차적으로 파고 상승이 일어남에 따른 것으로 추정된다. Characteristics of large-height swell-like waves that repeatedly occurred on the Korean East Coast in winter season were analyzed by using the wave observation data and the meteorological data. Based on the results of the data analysis, it was demonstrated that the swell-like waves have been generated due to the long-lasting strong northeasters in the East Sea, which were formed as a result of the low pressure trough in the vicinity of the extratropical low pressure system that advanced to East Sea from the China inland with decreasing its central pressure. Among the recently occurred events of the swell-like waves, the characteristics of the two events in October 2005 and 2006 were predominantly wind waves. Meanwhile, the one in February 2008 seems to be occurred by the initial wave growth due to wind waves followed by the secondly increase of the wave height due to longer-period swell.

Identification of Transformed Image Using the Composition of Features

Won-Keun Yang,Ayoung Cho,Ik-Hwan Cho,Weon-Geun Oh,Dong-Seok Jeong 한국멀티미디어학회 2008 멀티미디어학회논문지 Vol.11 No.6

Immunohistochemical localization of insulin-like growth factor binding protein 2 in the central nervous system of SOD1G93A transgenic mice

Sim, Sung Eun,Chung, Yoon Hee,Jeong, Ji Hoon,Yun, Sin Weon,Lim, Hyoun-Sub,Kim, Daejin,Kim, Sung Su,Lee, Won Bok,Cha, Choong Ik Springer-Verlag 2009 Journal of molecular histology Vol.40 No.2

Identification of Transformed Image Using the Composition of Features

Yang, Won-Keun,Cho, A-Young,Cho, Ik-Hwan,Oh, Weon-Geun,Jeong, Dong-Seok Korea Multimedia Society 2008 멀티미디어학회논문지 Vol.11 No.6

Image identification is the process of checking whether the query image is the transformed version of the specific original image or not. In this paper, image identification method based on feature composition is proposed. Used features include color distance, texture information and average pixel intensity. We extract color characteristics using color distance and texture information by Modified Generalized Symmetry Transform as well as average intensity of each pixel as features. Individual feature is quantized adaptively to be used as bins of histogram. The histogram is normalized according to data type and it is used as the signature in comparing the query image with database images. In matching part, Manhattan distance is used for measuring distance between two signatures. To evaluate the performance of the proposed method, independent test and accuracy test are achieved. In independent test, 60,433 images are used to evaluate the ability of discrimination between different images. And 4,002 original images and its 29 transformed versions are used in accuracy test, which evaluate the ability that the proposed algorithm can find the original image correctly when some transforms was applied in original image. Experiment results show that the proposed identification method has good performance in accuracy test. And the proposed method is very useful in real environment because of its high accuracy and fast matching capacity.