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RISS 인기검색어
- 검색키워드
- 저자 : Weizhao Lu (검색결과 2 건)
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Lin, Jing,Li, Xican,Chen, Li,Lu, Weizhao,Chen, Xianwen,Han, Lu,Chen, Dongfeng Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
[6]-Gingerol is known as the major bioactive constituent of ginger. In the study, it was observed to effectively protect against ${\bullet}OH$-induced DNA damage ($IC_{50}$ $328.60{\pm}24.41{\mu}M$). Antioxidant assays indicated that [6]-gingerol could efficiently scavenge various free radicals, including ${\bullet}OH$ radical ($IC_{50}$ $70.39{\pm}1.23{\mu}M$), ${\bullet}O_2{^-}$ radical ($IC_{50}$ $228.40{\pm}9.20{\mu}M$), $DPPH{\bullet}$radical ($IC_{50}$ $27.35{\pm}1.44{\mu}M$), and $ABTS{^+}{\bullet}$radical ($IC_{50}$ $2.53{\pm}0.070{\mu}M$), and reduce $Cu^{2+}$ ion ($IC_{50}$ $11.97{\pm}0.68{\mu}M$). In order to investigate the possible mechanism, the reaction product of [6]-gingerol and $DPPH{\bullet}$ radical was further measured using HPLC combined mass spectrometry. The product showed a molecular ion peak at m/z 316 $[M+Na]^+$, and diagnostic fragment loss (m/z 28) for quinone. On this basis, it can be concluded that: (i) [6]-gingerol can effectively protect against ${\bullet}OH$-induced DNA damage; (ii) a possible mechanism for [6]-gingerol to protect against oxidative damage is ${\bullet}OH$ radical scavenging; (iii) [6]-gingerol scavenges ${\bullet}OH$ radical through hydrogen atom ($H{\bullet}$) transfer (HAT) and sequential electron (e) proton transfer (SEPT) mechanisms; and (iv) both mechanisms make [6]-gingerol be oxidized to semi-quinone or quinone forms.
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Jing Lin,Xican Li,Li Chen,Weizhao Lu,Xianwen Chen,Lu Han,Dongfeng Chen 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
[6]-Gingerol is known as the major bioactive constituent of ginger. In the study, it was observed to effectively protect against •OH-induced DNA damage (IC50 328.60 ± 24.41 μM). Antioxidant assays indicated that [6]- gingerol could efficiently scavenge various free radicals, including •OH radical (IC50 70.39 ± 1.23 μM), •O2 − radical (IC50 228.40 ± 9.20 μM), DPPH• radical (IC50 27.35 ± 1.44 μM), and ABTS+• radical (IC50 2.53 ± 0.070 μM), and reduce Cu2+ ion (IC50 11.97 ± 0.68 μM). In order to investigate the possible mechanism, the reaction product of [6]-gingerol and DPPH• radical was further measured using HPLC combined mass spectrometry. The product showed a molecular ion peak at m/z 316 [M+Na]+, and diagnostic fragment loss (m/z 28) for quinone. On this basis, it can be concluded that: (i) [6]-gingerol can effectively protect against •OH-induced DNA damage; (ii) a possible mechanism for [6]-gingerol to protect against oxidative damage is •OH radical scavenging; (iii) [6]-gingerol scavenges •OH radical through hydrogen atom (H•) transfer (HAT) and sequential electron (e) proton transfer (SEPT) mechanisms; and (iv) both mechanisms make [6]-gingerol be oxidized to semi-quinone or quinone forms.
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