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Weiwen Yu World Association for Triple Helix and Future Stra 2023 Journal of Contemporary Eastern Asia Vol.22 No.2
This study examined China's public and government agenda setting in response to the Shanghai lockdown due to the COVID-19 pandemic. It employed content analysis, correlation, and Granger's causality tests to analyze 1,717 Weibo posts published by the public and the Shanghai Municipal Government from March 12 to June 1, 2022. The results showed that (1) pandemic statistics were the central attribute in the government agenda, while civil life, community management, and government and policies were the central attributes in the public agenda; (2) the government's agenda unidirectionally influenced the public agenda in terms of government policy attributes; and (3) the government and public agendas reciprocally influenced each other in terms of economic attributes. This study contributed to the existing literature by examining agenda-setting dynamics in a city closure event during the COVID-19 epidemic. It also extended existing methods by modeling implicit relationships between attributes in the public and government agendas.
A Bayesian optimal design for degradation tests based on the inverse Gaussian process
Weiwen Peng,Yu Liu,Yanfeng Li,Shun-Peng Zhu,Hong-Zhong Huang 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.10
The inverse Gaussian process is recently introduced as an attractive and flexible stochastic process for degradation modeling. This processhas been demonstrated as a valuable complement for models that are developed on the basis of the Wiener and gamma processes. We investigate the optimal design of the degradation tests on the basis of the inverse Gaussian process. In addition to an optimal designwith pre-estimated planning values of model parameters, we also address the issue of uncertainty in the planning values by using theBayesian method. An average pre-posterior variance of reliability is used as the optimization criterion. A trade-off between sample sizeand number of degradation observations is investigated in the degradation test planning. The effects of priors on the optimal designs andon the value of prior information are also investigated and quantified. The degradation test planning of a GaAs Laser device is performedto demonstrate the proposed method.
p53 overexpression represses androgen-mediated induction ofNKX3.1 in a prostate cancer cell line
Anli Jiang,Chunxiao Yu,Pengju Zhang,Weiwen Chen,Wenwen Liu,Xiaoyan Hu,Jianye Zhang 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.6
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known about the relationships and interactions between p53 and NKX3.1 in prostate cancer. We found that NKX3.1 expression is down-regulated by over-expression of wild type (wt) p53 in prostate cancer LNCaP cells. NKX3.1 is down-regulated at both the mRNA and protein levels by p53 overexpression due to either transient transfection of exogenous p53 or induction of endogenous p53. p53 over-expression represses androgen-induced transactivation of NKX3.1 by inhibiting the promoter of the androgen acceptor (AR) gene and by blocking AR-DNA binding activity. In addition, transfection with the p21 expression vector (pPSA-p21) showed that p21 does not reduce NKX3.1 expression, indicating that NKX3.1 expression is not the result of nonspecific effects of cell growth arrest. Our results provide biochemical and cellular biologic evidence that NKX3.1 is down-regulated by p53 over-ex - pression in prostate cancer cells.