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- 저자 : Weijie Gu (검색결과 3 건)
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Boost-type push-pull converter with reduced switches
Gu, Aiyu,Sun, Weijie,Zhang, Guidong,Chen, Sizhe,Wang, Yu,Yang, Ling,Zhang, Yun The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.3
This paper develops and analyses a boost-type push-pull converter with a reduced number of switches. The newly designed converter mainly consists of five diodes, two switches, two inductors, a transformer and two capacitors. By tuning the duty cycle and the transformer ratio, different voltage gains of the proposed converter can be obtained. It is notable for its electrical isolation characteristics. When compared with traditional step-up converters, the step-up module and converter module share the same switch. In addition, the control of the converter becomes easier to implement, and it has better stability and a reduced volume. It should be mentioned that the number of switches in the proposed converter is decreased but maintains the same voltage stress when compared to the traditional structure. The operating principle of proposed converter is demonstrated, which is followed by the design of the component parameters. To validate the feasibility of the proposed topology, an experimental prototype is constructed to verify its correctness and practicability of the proposed converter when compared with the conventional converter.
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Fluid-structure interaction analysis of heat exchanger with torsional flow in the shell side
Xin Gu,Guan Wang,Qianxin Zhang,Cheng Chen,Ning Li,Weijie Chen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.1
Based on the theory of fluid-structure interaction (FSI), the flow characteristics and mechanical properties of torsional flow heat exchanger (TFHX) and cross torsional flow heat exchanger (CTFHX) were numerically studied. The simulation results were compared with the experimental results to verify the reliability of the numerical simulation. The results show that the pressure drop of CTFHX decrease is 30.31-32.56 % lower than that of TFHX, and the heat transfer coefficient is found to lower by 16.8-18.5 %, but the comprehensive performance h/∆P is increased by 14.8-17.9 %. There is also a higher stress around the baffle holes, and the influence of temperature load on stress is much greater than that of pressure load. Moreover, the linearization results of hazardous locations show that CTFHX has greater stress. This study provides theoretical guidance for the structural optimization and equipment maintenance of heat exchanger.
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miR-98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL-6
Fei Li,Xin-ji Li,Li Qiao,Fei Shi,Wen Liu,You Li,Yu-ping Dang,Weijie Gu,Xiao-gang Wang,Wei Liu 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-
Dysregulated microRNA (miRNA) expression has a critical role in tumor development and metastasis. However, the mechanism by which miRNAs control melanoma metastasis is unknown. Here, we report reduced miR-98 expression in melanoma tissues with increasing tumor stage as well as metastasis; its expression is also negatively associated with melanoma patient survival. Furthermore, we demonstrate that miR-98 inhibits melanoma cell migration in vitro as well as metastatic tumor size in vivo. We also found that IL-6 is a target gene of miR-98, and IL-6 represses miR-98 levels via the Stat3-NF-κB-lin28B pathway. In an in vivo melanoma model, we demonstrate that miR-98 reduces melanoma metastasis and increases survival in part by reducing IL-6 levels; it also decreases Stat3 and p65 phosphorylation as well as lin28B mRNA levels. These results suggest that miR-98 inhibits melanoma metastasis in part through a novel miR-98-IL-6-negative feedback loop.
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