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Liu Xiaoyi,Wei Qinglv,Yang Chenyue,Zhao Hongyan,Xu Jie,Mobet Youchaou,Luo Qingya,Yang Dan,Zuo Xinzhao,Chen Ningxuan,Yang Yu,Li Li,Wang Wei,Yu Jianhua,Xu Jing,Liu Tao,Yi Ping 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional regulation, in ovarian cancer, is poorly understood. In this study, we revealed that the RNA methyltransferase NSUN2 facilitates mRNA m5C modification and forms a positive feedback regulatory loop with the transcription factor E2F1 in ovarian cancer. Specifically, NSUN2 promotes m5C modification of E2F1 mRNA and increases its stability, and E2F1 binds to the NSUN2 promoter, subsequently reciprocally activating NSUN2 transcription. The RNA binding protein YBX1 functions as the m5C reader and is involved in NSUN2-mediated E2F1 regulation. m5C modification promotes YBX1 phase separation, which upregulates E2F1 expression. In ovarian cancer, NSUN2 and YBX1 are amplified and upregulated, and higher expression of NSUN2 and YBX1 predicts a worse prognosis for ovarian cancer patients. Moreover, E2F1 transcriptionally regulates the expression of the oncogenes MYBL2 and RAD54L, driving ovarian cancer progression. Thus, our study delineates a NSUN2-E2F1-NSUN2 loop regulated by m5C modification in a manner dependent on YBX1 phase separation, and this previously unidentified pathway could be a promising target for ovarian cancer treatment.
A GENERALIZED DISCOUNTED CASH FLOW MODEL TO COMPUTE STOCK PRICE
Wei ping Liu People&Global Business Association 2005 Global Business and Finance Review Vol.10 No.2
The discounted cash flow method is a commonly-used tool to value security prices. For stock valuation, analysts usually assume companies will pay dividends in a certain pattern. Based on these assumptions, three models were developed to compute stock prices, and they are introduced in most textbooks of financial management. These models, particularly the different growth model, have several limitations. Not only are they cumbersome and error-prone, but they also take too many steps to compute th estock price. These models could be very time-consuming, particularly when the first stage is long. To remedy these problems, a simpler and more general model is developeddebt level when the adjustment requires an increase in debt level according to the target adjustment model.
Liu-Jing Wei,Ji-lai Zhou,Dan-ni Zhu,Bai-yi Cai,Jin-Ping Lin,Qiang Hua,Dong-Zhi Wei 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.6
In this study a new insight was provided to understand the functions of membrane-bound alcohol dehydrogenase (mADH) and aldehyde dehydrogenase (mALDH) in the bio-oxidation of primary alcohols, diols and poly alcohols using the resting cells of Gluconobacter oxydans DSM 2003 and its mutant strains as catalyst. The results demonstrated that though both mADH and mALDH participated in most of the oxidation of alcohols to their corresponding acid, the exact roles of these enzymes in each reaction might be different. For example,mADH played a key role in the oxidation of diols to its corresponding organic acid in G. oxydans, but it was dispensable when the primary alcohols were used as substrates. In contrast to mADH, mALDH appears to play a relatively minor role in organic acid-producing reactions because of the possible presence of other isoenzymes. Aldehydes were, however, found to be accumulated in the mALDH-deficient strain during the oxidation of alcohols.
THE IMP ACT OF INFORMATION ASYMMETRY ON THE NEW EQUITY ISSUE TIMING
Wei ping Liu 사람과세계경영학회 2000 Global Business and Finance Review Vol.5 No.1
Undervaluation of the firm coupled with the information asymmetry between the issuing firm's management and market investors might be the reasons why new equity issues, on average, are preceded by a large and extended abnormal price rise in the market. If a firm is undervalued (i.e. the intrinsic value of the firm is above its market value) and new equities are needed to finance a new project, the current equity holders would lose a portion of the originally undervalued part after the gap between the market value and the intrinsic. value is eliminated. To avoid this disadvantageous information asymmetry, issuing firm's management is motivated to release inside information to bid up the firm's stock price so that new equity issue will be more beneficial to the issuing firm.
Liu Na,Feng Yuchen,Liu Huicheng,Wu Wenliang,Liang Yuxia,Li Pingfei,Wei Zhengping,Wu Min,Tang Zhao-Hui,Han Junyan,Cheng Xiang,Liu Zheng,Laurence Arian,Li Huabin,Zhen Guohua,Yang Xiang-Ping 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.3
Purpose Macrophages are important regulators of environmental allergen-induced airway inflammation and asthma. ATP6V0d2 is a subunit of vacuolar ATPase highly expressed in macrophages. However, the functions of ATP6V0d2 in the regulation of pathogenesis of allergic asthma remain unclear. The aim of this study is to determine the function and related molecular mechanisms of macrophage protein ATP6V0d2 in allergic asthma. Methods We compared the disease severity between female C57BL/6 wild-type and ATP6V0d2−/− mice in an ovalbumin (OVA)-induced asthma model. We also investigated the association of expression of ATP6V0d2, PU.1 and CCL17 with disease severity among asthmatic patients. Results The expression of ATP6V0d2 in sputum cells of asthmatic patients and in the lungs of OVA-challenged mice was enhanced compared to healthy subjects and their counterparts, respectively. However, ATP6V0d2-deficient mice exaggerated inflammatory cell infiltration as well as enhanced alternative activated macrophage (AAM) polarization and mucus production in an OVA-induced asthma model. Furthermore, we found that Atp6v0d2 promoted lysosomal degradation of Pu.1, which induced AAM polarization and Ccl17 production. Among asthma patients, ATP6V0d2 expression was inversely associated with disease severity, whereas PU.1 and CCL17 expression was positively associated with disease severity. Conclusions Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.
AN EMPIRICAL STUDY OF THE IMPACT OF DEBT SERVICE RATIO VOLATILITY ON DEBT SERVICE CAPACITY
Wei ping Liu People&Global Business Association 1997 Global Business and Finance Review Vol.2 No.2
Financial theoreticians have two diametrically opposed opinions on whether high volatility of indicators of a sovereign's debt service capacity (DSC) will affect its DSC or not. This paper summarizes these opinions into several hypotheses and examines them empirically. Data of debt service ratio and DSC of 105 countries between 1985-1992 were collected and volatility of each country's debt service ratios are computed. Stepwise logistics regression analyses and multivariate Chi-square tests a re conducted to test the relationship between the volatility of a country's DSC indicators and its DSC. Evidence has been found that generally DSC indicators' volatility is not a significant factor affecting a sovereign's DSC. This is probably because the major concern of a sovereign is the reputation of the nation so that the country can maintain a stable source of future international loans. When a borrowing country encounters financial shocks, it often adopts austerity policy and will default its loan only as a last resort. However, among medium-income countries, DSC indicators' volatility does affect a sovereign's DSC. This is probably because the governments in those countries are politically weak and cannot cutback imports to lower the nation's consumption level and make voters unhappy.