Research on the Relationship Between Serum Levels of Inflammatory Cytokines and Non-small Cell Lung Cancer

Song, Xiao-Yun,Zhou, Shi-Jie,Xiao, Ning,Li, Yun-Song,Zhen, De-Zhi,Su, Chong-Yu,Liu, Zhi-Dong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Aims: This study was conducted to evaluate the levels of TNF-${\alpha}$, IL-6, IL-8 and VEGF in serum of patients with non- small cell lung cancer, for assessing their possible diagnostic and prognostic roles. Methods: We enrolled 48 patients newly diagnosed with non-small cell lung cancer and 40 healthy controls. TNF- ${\alpha}$, IL-6 and IL-8 levels were measured in the serum of all the subjects with specific radioimmunoassay kits, while EGF was analyzed by sandwich enzyme immunoassay techniques. Results: A statistically significant difference was observed between lung cancer patients and the control group regarding the values of TNF-${\alpha}$, IL-6, IL-8 and VEGF in serum. Moreover, TNF-${\alpha}$, IL-8 and VEGF levels were higher in patients with advanced stages compared to early stages. In addition, higher serum levels of TNF-${\alpha}$, IL-6, IL-8 and VEGF were found in smokers than in non-smokers, both in patients and controls. Conclusion: Serum levels of TNF-${\alpha}$, IL-6, IL-8 and VEGF were all elevated in lung cancer patients, suggesting that inflammatory cytokines could be jointly used as a screening tool. Though TNF-${\alpha}$, IL-8 and VEGF levels were related to advanced disease, long-term survival studies of NSCLC patients should be performed to confirm whether they can act as biomarkers of advanced disease. In addition, smoking would be an important contributor to the processes of inflammation and lung cancer.

Recent Studies Conducted in Environmental Health Field in KMC : Analyse the interaction of Combined-pesticide

( Xiao Xiao Song ) 한국환경보건학회(구-한국환경위생학회) 2004 Current Challenges and Advances in Environmental H Vol.- No.-

Reliability and Validity of Chinese Version of the Perceived Competence Scale for Disaster Mental Health Workforce: A Cross-Sectional Study

Qingqing Xiao(Qingqing Xiao),Xiaozhen Song(Xiaozhen Song),Xuehua Huang(Xuehua Huang),Xiandong Meng(Xiandong Meng) 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.3

Objective This study aimed to translate the English version of the Perceived Competence Scale for Disaster Mental Health Workforce (PCS-DMHW) into Chinese, and to test its reliability and validity in Chinese mental health workers.Methods With the consent of Professor Choi, Keimyung University, Korea, and the authorization of the scale, the English version of PCS-DMHW was translated, retranslated and culturally debugged to form the Chinese version of PCS-DMHW. The general information questionnaire and the Chinese version of PCS-DMHW scale were used to investigate 706 mental health workforce from 9 tertiary hospitals in Sichuan province in China from March 24, 2020 to April 14, 2020. The Cronbach’s α coefficient was used to evaluate the internal consistency reliability of the scale, and the test-retest correlation coefficient r was used to evaluate the test-retest reliability of the scale. The content validity indexes (CVI) and exploratory factor analysis (EFA) was used separately for evaluating the content validity and structure validity of the scale.Results The Cronbach’s α coefficient of the Chinese version of PCS-DMHW total scale, individual competences and organizational competences subscale was 0.978, 0.956, and 0.964, respectively. The test-retest reliability of the total scale, individual competences and organizational competences subscale was 0.949, 0.932 and 0.927, respectively. The item-level CVI of all scale were ranged from 0.833-1.000, the scale-level CVI (S-CVI)/universal agreement of the total scale, individual competences and organizational competences subscale was 0.833, 0.875, and 0.857, respectively, and the S-CVI/average was 0.972, 0.979, and 0.976, respectively. EFA showed that two principal components were extracted from the subscale of individual competences and organizational competences.Conclusion The Chinese version of PCS-DMHW has good reliability and validity, and can be widely used in China.

HIF-1α and GLUT1 Gene Expression is Associated with Chemoresistance of Acute Myeloid Leukemia

Song, Kui,Li, Min,Xu, Xiao-Jun,Xuan, Li,Huang, Gui-Nian,Song, Xiao-Ling,Liu, Qi-Fa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Aims: Much evidence suggests that increased glucose metabolism in tumor cells might contribute to the development of acquired chemoresistance. However, the molecular mechanisms are not fully clear. Therefore, we investigated a possible correlation of mRNA expression of HIF-$1{\alpha}$ and GLUT1 with chemoresistance in acute myeloid leukemia (AML). Methods: Bone marrow samples were obtained from newly diagnosed and relapsed AML (M3 exclusion) cases. RNA interference with short hairpin RNA (shRNA) was used to stably silence GLUT1 or HIF-$1{\alpha}$ gene expression in an AML cell line and HIF-$1{\alpha}$ and GLUT1 mRNA expression was measured by real-time quantitative polymerase chain reaction assay (qPCR). Results: High levels of HIF-$1{\alpha}$ and GLUT1 were associated with poor responsiveness to chemotherapy in AML. Down-regulation of the expression of GLUT1 by RNA interference obviously sensitized drug-resistant HL-60/ADR cells to adriamycin (ADR) in vitro, comparable with RNA interference for the HIF-$1{\alpha}$ gene. Conclusions: Our data revealed that over-expression of HIF-$1{\alpha}$ and GLUT1 might play a role in the chemoresistance of AML. GLUT1 might be a potential target to reverse such drug resistance.

Efficient Measurement Method for Spatiotemporal Compressive Data Gathering in Wireless Sensor Networks

( Xiao Xue ),( Song Xiao ),( Lei Quan ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.4

By means of compressive sensing (CS) technique, this paper considers the collection of sensor data with spatiotemporal correlations in wireless sensor networks (WSNs). In energy-constrained WSNs, one-dimensional CS methods need a lot of data transmissions since they are less applicable in fully exploiting the spatiotemporal correlations, while the Kronecker CS (KCS) methods suffer performance degradations when the signal dimension increases. In this paper, an appropriate sensing matrix as well as an efficient sensing method is proposed to further reduce the data transmissions without the loss of the recovery performance. Different matrices for the temporal signal of each sensor node are separately designed. The corresponding energy-efficient data gathering method is presented, which only transmitting a subset of sensor readings to recover data of the entire WSN. Theoretical analysis indicates that the sensing structure could have the relatively small mutual coherence according to the selection of matrix. Compared with the existing spatiotemporal CS (CS-ST) method, the simulation results show that the proposed efficient measurement method could reduce data transmissions by about 25% with the similar recovery performance. In addition, compared with the conventional KCS method, for 95% successful recovery, the proposed sensing structure could improve the recovery performance by about 20%.

Over-expression of StLCYb increases b-carotene accumulation in potato tubers

Xiao-yan Song,Wen-jiao Zhu,Rui-min Tang,Jing-hui Cai,Min Chen,Qing Yang 한국식물생명공학회 2016 Plant biotechnology reports Vol.10 No.2

Lycopene b-cyclase (LCYb) is involved in the first step of the b-branch synthetic pathway of carotenoids from lycopene in plants. In this study, to explore the possibility of regulating b-carotene synthesis via the b-branchspecific pathway in potato, StLCYb gene was first isolated from potato cultivar Desiree, and its open reading frame was 1503 bp long without intron. The protein sequence of StLCYb showed high similarity with that of LCYbs in other species such as SlLCYb1, CaLCYb, NtLCYb and ApLCYb. StLCYb was expressed in all tissues and the highest level was observed in tubers followed in flowers, and the lowest level was in roots. HPLC detected an about 1.5–1.9 times increase in b-carotene content of transgenic potato tubers, in which the gene StLCYb was overexpressed, compared with the wild-type control. Besides, the expression levels of carotenoid-related genes StPSY, StPDS, StZDS, StCHYb and StZEP transcripts in the transgenic lines were significantly higher than in the wild-type control, which implied a positive regulation in promoting carotenoid synthesis. All these results suggest that b-carotene content in potato tubers could be regulated by modulating StLCYb expression.

Predictors for Better Blood-Flow Restoration of Long-Segmental Below-the-Knee Chronic Total Occlusions after Endovascular Therapy in Diabetic Patients

Xiao-Li Song,Yue-Qi Zhu,Hai-Tao Lu,Fang Liu,Li-Ming Wei,강형근,Jun-Gong Zhao 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.6

Objective: To prospectively investigate predictors for good restoration of blood flow of below-the-knee (BTK) chronic total occlusions (CTOs) after endovascular therapy in diabetes mellitus (DM) patients. Materials and Methods: A total of 120 long-segmental (≥ 5 cm) BTK, CTOs in 81 patients who underwent recanalization were included in this study. After angioplasty, blood-flow restoration was assessed using modified thrombolysis in myocardial ischemia grades and classified as good flow (grade 3) and poor flow (grade 1/2). One hundred and six CTOs with successful recanalization were divided into a good flow group (GFG; n = 68) and poor flow group (PFG; n = 38). Multivariate logistic regression analyses were undertaken to determine independent predictors of blood-flow restoration. Receiver operating characteristic curves were constructed to determine the best cutoff value. The prevalence of target-lesion restenosis during follow-up was compared between two groups. Results: Univariate analyses suggested that CTOs in GFG were characterized by lighter limb ischemia (p = 0.03), shorter course of ischemic symptoms (p < 0.01) and lesion length (p = 0.04), more frequent use of intraluminal angioplasty (p = 0.03), and higher runoff score (p < 0.01) than those in PFG. Multivariate regression analyses suggested that distal runoffs (p = 0.001; odds ratio [OR], 10.32; 95% confidence interval [CI]: 4.082–26.071) and lesion length (p < 0.001; OR, 1.26; 95% CI: 1.091–1.449) were independent predictors for good flow restoration. Kaplan-Meier analyses at 12 months showed a higher prevalence of non-restenosis in GFG (p < 0.01). Conclusion: Distal runoffs and lesion length are independent predictors for good flow restoration for long-segmental BTK, CTOs in DM patients who receive endovascular therapy.

Nonfragile Dissipative Synchronization of Reaction-diffusion Complex Dynamical Networks with Coupling Delays

Xiao-Na Song,Renzhi Zhang,Mi Wang,Junwei Lu 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.3

This paper focuses on the synchronization of reaction-diffusion complex dynamical networks with coupling delay. In order to reflect the uncertainties of the controller, the nonfragile problem is considered. Furthermore, we also take into account the dissipativity analysis problem, which contains the H∞ performance and passivity performance in a unified framework. By utilizing the Lyapunov functional method, two sufficient delay-dependent conditions, which ensure the considered system is globally asymptotically synchronized onto the unforced node and strictly dissipative, are established in terms of linear matrix inequality. Finally, three numerical examples are employed to demonstrate the effectiveness of the design methods.

Bioinformatic Prediction of SNPs within miRNA Binding Sites of Inflammatory Genes Associated with Gastric Cancer

Song, Chuan-Qing,Zhang, Jun-Hui,Shi, Jia-Chen,Cao, Xiao-Qin,Song, Chun-Hua,Hassan, Adil,Wang, Peng,Dai, Li-Ping,Zhang, Jian-Ying,Wang, Kai-Juan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Polymorphisms in miRNA binding sites have been shown to affect miRNA binding to target genes, resulting in differential mRNA and protein expression and susceptibility to common diseases. Our purpose was to predict SNPs (single nucleotide polymorphisms) within miRNA binding sites of inflammatory genes in relation to gastric cancer. A complete list of SNPs in the 3'UTR regions of all inflammatory genes associated with gastric cancer was obtained from Pubmed. miRNA target prediction databases (MirSNP, Targetscan Human 6.2, PolymiRTS 3.0, miRNASNP 2.0, and Patrocles) were used to predict miRNA target sites. There were 99 SNPs with MAF>0.05 within the miRNA binding sites of 41 genes among 72 inflammation-related genes associated with gastric cancer. NF-${\kappa}B$ and JAK-STAT are the two most important signaling pathways. 47 SNPs of 25 genes with 95 miRNAs were predicted. CCL2 and IL1F5 were found to be the shared target genes of hsa-miRNA-624-3p. Bioinformatic methods could identify a set of SNPs within miRNA binding sites of inflammatory genes, and provide data and direction for subsequent functional verification research.

New MIT Control Strategy Combined with Iterative Learning Control

Xiao Song,Jingzhuo Shi 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.7

As the pioneer of model reference adaptive control (MRAC) method, MIT control strategy is still used in various practical applications. In this paper, MIT is applied to the speed control of ultrasonic motor, trying to use a relatively simple control method to obtain good control performance. However, MIT control strategy only adjusts the gain, so it is difficult to achieve a large correction of the system’s dynamic characteristics, which limits the actual performance. To solve this problem, two improved MIT control strategies based on iterative learning are proposed in this paper to enhance the control performance. Both methods adopt the P-type iterative learning control (P-ILC) strategy with simplest structure. One is to connect the P-ILC controller with the MIT controller in series to adjust the given value of the MIT controller in real time. The other is to use the P-ILC controller to adjust the adaptive gain of the MIT controller in real time, so as to enhance its control freedom and adaptive ability to deal with complex objects. The experimental results show that the proposed control strategies have their own advantages and can significantly improve the control performance after finite iterative learning processes.