치매 치료에 대한 한의학적 접근 방법

황의완 경희대학교 1997 慶熙醫學 Vol.13 No.1

기능성 위장관장애 환자의 자율신경계기능과 음-양(陰陽)체질 특성에 관한 연구

이정호,송지영,황의완,정두훈,김영미 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 기질적 원인이 없이 장기간 소화장애 및 복통이 지속되는 기능성 위장관 장애 환자를 대상으로 하여, 음양체질의 특성이 위장관을 조절하는 자율신경계 기능 이상과 관련되는지를 알아보기 위하여, 사상체질 특성에 따른 자율신경계 기능의 차이유무를 측정해 보고자 하였다. 이로써 이들 환자에서 보이는 자율신경계 기능의 불균형 상태가 한의학에서 말하는 음양(陰陽)이론으로 설명할 수 있을지 알아 보고자 하였다. 그리고 만일 이러한 설명이 가능하게 되면 향후 기능성 위장관 장애 환자에 대한 음양이론에 입각한 치료의 이론적 배경이 될 것으로 기대하였다. 방 법 : 기능성 위장관 장애 환자 27명과 대조군으로서 위장관 증상 이외의 증상을 가진 신체형 장애 환자(이하 기타 신체형 장애) 28명과 건강 대조군 26명을 조사 대상으로 하였다. 이들에게 사상체질(四象體質)분류검사를 이용하여 소음 체질과 기타 체질군으로 나누고, 자율신경 기능검사를 실시하여 체질에 따른 자율신경계 기능을 비교해 보았다. 결 과 : 기능성 위장관 환자군에서 소음체질이 의미있게 많은 빈도를 차지하지는 않았으며, 기능성 위장관 장애군과 기타 신체형 장애군과의 비교에서 자율신경 기능의 차이는 없었다. 이로서 비기질성 기능 장애의 하나인 기능성 위장 장애에서 체질 특성과 부교감신경계 기능 저하와는 관련성은 거의 없다고 추정된다. 단지 기능성 위장 장애군과 기타 신체형 장애군을 합한 신체형 장애 환자군에서는 건강 대조군에 비하여 소음체질의 빈도가 높았으며 부교감신경 기능이 의미있게 낮은 소견을 보였다. 결 론 : 비기질성 기능 장애인 기능성 위장관 장애에서는 한의학에서의 음양가설이라는 일원론에 입각한 이분법적인 개념이 자율신경계의 교감, 부교감 신경계 기능과 일치하는 부분은 적은 것으로 추정된다. 기능성 위장관 장애를 대상으로 해서 앞으로는 음양의 체질이라는 포괄적인 개념보다는 확실한 증상 몇 개 중심으로 하는 좀 더 세분화된 부분으로부터 접근해 볼 필요가 있으리라 사료된다. Objectives : It was revealed that autonomic dysfunction especially decreased parasympathetic functions, seems to be one of the major etiological factors in functional gastrointestinal disorders(FGID). The physiological characteristics of sympathetic and parasympathetic functions are externally similar to the features of Yin and Yang based on oriental medicine theory. And it was also revealed that gastrointestinal symptoms are prevalent in Lesser Yin con-stitutional type(少陰) originated from four types of constitution shown in Sasang constitutional theory(四象醫學). If we obtain the findings on the similarities or compatibilities between autonomic nervous functions and physical constitutional features in functional gastrointestinal disorders, we could apply various oriental treatment modalities to the patients with functional disorders, especially according to Yin-Yang constitutional concept. Methods : We investigated the correlations between characteristics of physical constitution (Yin and Yang) and imbalance of the autonomic functions in patients with FGID. Subjects consisted with three groups : 27 patients with FGID (including irritable bowel syndrome, functional dyspepsia, functional abdominal pain syndrome according to the Rome criteria), 28 patients with somatoform disorders who had symptoms other than abdominal symptoms(other somatoform disorders), and 26 normal healthy controls. Characteristics of constitutions were evaluated and divided into two major groups, i.e., Lesser Yin constitution and other constitutions(Greater Yin & Yang and Lesser Yang included) according to the Je-Ma Lee's Classification Questionnaire for Four Constitutional Types(Song et al. 1993). For evaluating the autonomic functions, three parasympathetic functions and two sympathetic functions were measured. Levels of anxiety and depression were also evaluated to be used as a covariant controlling the autonomic functions. Results : 1) FGID group showed significantly lower parasympathetic functions compared to healthy controls, however, there was no differences between FGID and other somatoform disorder groups. 2) Lesser Yin constitutional type was not so prevalent in FGID group. 3) When FGID and other somatoform disorder groups were combined and compared with normal healthy controls, the former group showed significantly lower parasympathetic functions than the latter group. Conclusions : According to these results, Lesser Yin constitutional type do not seem to be closely related with FGID. However, it was suggested that decreased parasympathetic functions were partly associated with this group. We could not find any correlations or compatibilities between two constitutional characteristics and autonomic dysfunction in FGID. This means that functional symptoms of FGID when those were deducted as Yin and Yang characteristics based on oriental medicine could not be understood as two oppositional and co-operative functions such as autonomic functions. Further research with more restricted symptoms selected in the functional disorders and with other physiological cues applied would be needed.

Cancer Registration in the Peoples Republic of China

Wei, Kuang-Rong,Chen, Wan-Qing,Zhang, Si-Wei,Liang, Zhi-Heng,Zheng, Rong-Shou,Ou, Zhi-Xiong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

The current situation of cancer registration in China was systematically reviewed. So far, cancer registration in China has been making a great progress in the following aspects: the number of cancer registries and covered population have increased dramatically; a registration network has been established and completed gradually; regulations and rules improved remarkably; more attention is being paid by every level of government; a lot of registration software has been created and financial support ensured. However, we are still facing some problems and challenges, such as no stable groups of registrars, shortage of training opportunities, poor data quality, insufficient utilization and lack of multidisciplinary mechanisms, so that the cancer registration system still needs to be enhanced and improved. Along with the development of economy, science and information technology, methods and patterns of cancer registration is changing. It is to be expected that cancer registration will be automatic, nationwide and integrated with community healthcare in the near future.

Analysis on the safe distance between shield tunnel through sand stratum and underlying karst cave

Wei Wan,Shiming Gao,Lingfeng Liu,Wushuang Wen,Ping Li,Jianping Chen 한국자원공학회 2019 Geosystem engineering Vol.22 No.2

When a subway tunnel passes through a karst geological area, in order to ensure the stability of the tunnel, the safe distance between the tunnel and karst cave needs to be researched. This article is based on the construction project of Wuhan metro line 6 from Qianjincun station to Mayinglu station. In view of the geological condition of overlying sand and underlying limestone, by using numerical simulation and theoretical calculation and selecting a characteristic section, the influence law and degree of karst cave span, height-span ratio, and filling degree on the safe thickness of karst cave roof are studied and a forecasting model of the safe thickness of karst cave roof is established. Combined with dichotomy and numerical simulation, the critical horizontal safe distance beyond which cave collapse does not cause tunnel instability is calculated. The results show that: (1) the safe thickness of karst cave roof increases linearly with the increase of karst cave span, and decreases with the increase of height-span ratio and filling degree; (2) among the three factors, the effect of karst cave span is the most significant, the filling degree of karst cave is the second, and the influence of height-span ratio of karst cave is the weakest; (3) the proposed forecasting model passes the significance test, indicating that the model is very reasonable; and (4) the critical horizontal safe distance from the tunnel border to the karst cave boundary is 22.4 m. The research results can provide guidance for the design and construction of shield tunnels and karst cave treatment in karst areas.

ATAD2 is Highly Expressed in Ovarian Carcinomas and Indicates Poor Prognosis

Wan, Wei-Na,Zhang, Yi-Xia,Wang, Xue-Mei,Liu, Yan-Jun,Zhang, Yu-Qin,Que, Yan-Hong,Zhao, Wen-Jing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

The purpose of this study was to explore the expression of ATAD2 in ovarian tumor tissue as well as its relationship with degree of malignancy. Tumor tissue from 110 cases of ovarian cancer was collected in accordance with the Declaration of Helsinki for evaluation of ATAD2 expression iimmunohistochemistry, quantitative PCR (qPCR) and Western blotting. The correlation between the ATAD2 expression and and the prognosis of ovarian cancer was evaluated by Cox regression model. In addition, HO-8910 and OVCAR-3 cells were transfected with two siRNAs targeting ATAD2. Cell viability was evaluated with MTT assay, and cell migration by transwell migration assay. ATAD2 was shown to be highly expressed in 65.5% (72/110) of ovarian cancer cases, both at transcriptional and protein levels. Moreover, highly expression was positively correlated with degree of malignancy. Knock-down of ATAD2 in HO-8910 and OVCAR-3 cells was found to reduce cell migration. In addition, follow-up visits of the patients demonstrated that the 5-year survival rate was lower in patients with high expression of ATAD2. Our study suggested that ovarian tumor tissue may have highly expressed ATAD2, which is associated with tumor stage, omentum-metastasis, ascites and CA-125. Increased ATAD2 may play important roles in tumor proliferation and migration. ATAD2 could serve in particular as a prognostic marker and a therapeutic target for ovarian cancer.

Study on aerodynamic coefficients and responses of the integrated catwalk of Halogaland Bridge

Wan, Jia-wei,Wang, Qi,Liao, Hai-li,Li, Ming-shui Techno-Press 2017 Wind and Structures, An International Journal (WAS Vol.25 No.3

Wind tunnel tests and numerical aerodynamic analyses were conducted for an integrated catwalk structure under strong winds. From the wind tunnel tests, it is found that the aerodynamic coefficients were different from those of the typical type. The drag coefficient was larger than typical and was sensitive to number of vertical meshes installed rather than the solidity ratio. Comparing with typical catwalk, the integrated one showed larger deformation under strong wind, and the large torsional deformation are mainly caused by drag force. It did not show aerodynamic divergence even the torsional deformation reaching $20^{\circ}$. The reason could be that the stiffness is smaller and thus the catwalk is able to deform to the shape compactable with higher loading. Considering safety for construction, storm rope system is introduced to the catwalk to reduce the deformation to acceptable level.

The Crystal Structure of One Natural Compound Cyclo-(1,10-Docandiamino-11,20-Docanedioic) Amide (1,12-Diazacyclodocosane-2,11-Dione)

Wei, Wan-Xing,Pan, Yuan-Jiang Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.11

1,12-diazacyclodocosane-2,11-dione was first isolated from a plant Phyllanthus niruri Linn. Its structure has been determined by means of spectroscopy methods and X-ray crystallography. Two peptide groups in the big ring (lactam) are the main factors influencing intermolecular contacts. The hydrogen-bond interaction of these hydrophilic groups is observed in the crystal structure. Meanwhile, C-H···O hydrogen bonds in molecules contribute to the formation of the whole crystal. These two kinds of hydrogen-bond form six- member rings among molecules. This compound crystallizes in the triclinic space group P-1 with a= 9.588(1) $\AA$, b= $9.850(1)\AA$, c = $11.810(1)\AA$, $\alpha=$ 68.18(1)$^{\circ}C$ , $\beta=$ 84.98(1), $\gamma$ = 86.03(1)$^{\circ}C$ , V = $1030.66(17)\AA3$ , Z = 2. A disorder of five-member carbon chain in the whole ring is observed in the title compound. The bond angle 105.8(4) is determined for a extreme configuration C(14)-C(15)-C(16), and 117.7(10) for another extreme configuration C(14')-C(15')-C(16'). In this crystal, two molecules are tied each other by short intermolecular hydrogen bonds, the oxygen atom being tied by hydrogen bond to nitrogen atom of another two molecules. The NMR and IR spectral data coincides to the structure of the compound.

Arge aurora Wei sp. nov. (Hymenoptera, Argidae) from China with a key to East Asian species of Arge nipponensis group

Wan Siying,Wu Duo,Niu Gengyun,Liu Ting,Wei Meicai 한국곤충학회 2022 Entomological Research Vol.52 No.1

Arge nipponensis group is proposed for 12 East Asian species. A key to species of this group is provided. Arge aurora Wei, sp. nov., a widespread species in China is described. It has been misidentified as Arge nipponensis Rohwer, 1910 in China since 1927. Arge nipponensis Rohwer is removed from the faunal list of China. The ovipositor and genitalia of A. nipponensis are described and figured for the first time. The geographic distribution analysis indicated that geographical barriers were probably the key to the distribution of A. aurora and A. nipponensis.

POLARIZATION PROPERTIES OF LARGE-AREA GaN-BASED LIGHT-EMITTING DIODES WITH AN OMNIDIRECTIONAL NANOSTRUCTURE

WAN-WEI WANG,LUNG-CHIEN CHEN,YA-HSIN WANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.5

Large-area GaN-based blue light-emitting diodes (LEDs) on sapphire substrates with an omnidirectional nanostructure consisted of Ag nanoparticles and TiO2/SiO2 Bragg re°ector were fabricated. For the LEDs without the omnidirectional nanostructure, the spectra of the P- and S-polarization light are lightly di®erent and the peak wavelength of P- and S-polarization light was estimated to be 464 nm and 463 nm, respectively at forward current of 20 mA. In contrast, for the LEDs with the omnidirectional nanostructure, the spectra of the P- and S-polarization light are nearly the same at forward current of 20mA and 100 mA.

New Lignan Isolated from Phyllanthus niruri Linn. Structure Elucidation by NMR Spectroscopy

Wei, Wan-Xing,Gong, Xing-guo,Ishrud, Omar,Pan, Yuan-Jiang Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.6