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Vascular Pathogenesis of Liver Cirrhosis
( Ian R. Wanless ) 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
Cirrhosis is a condition defined anatomically as the presence of fibrous septa throughout the liver that subdivide the hepatic parenchyma into hepatocellular nodules. A great deal of attention has been focused on the presence of fibrous tissue. Thus many
Kim, S.U.,Oh, H.J.,Wanless, I.R.,Lee, S.,Han, K.H.,Park, Y.N. Elsevier Science Publishers 2012 Journal of hepatology Vol.57 No.3
Backgrounds & Aims: The clinical severity of cirrhosis varies widely. We investigated whether histological sub-classification of cirrhosis using the Laennec system can discriminate different outcomes among patients with cirrhosis. Methods: One hundred and seventy-five patients with chronic liver disease who underwent liver biopsy and showed stage 3 or 4 fibrosis between January 2001 and December 2008 were prospectively enrolled. Cirrhosis was sub-classified into three groups (4A, 4B, and 4C) according to the Laennec system. The end point was liver-related event (LRE) occurrence, including decompensation, hepatocellular carcinoma, and liver-related death. Results: The median age of the patients (110 men, 65 women) was 55years. Stages 3, 4A, 4B, and 4C were identified in 46 (26.3%), 16 (9.1%), 82 (46.9%), and 31 (17.7%) patients, respectively. During the follow-up period, LREs occurred in 32 (18.3%) patients: 4 (8.7%) with stage 3, 2 (12.5%) with stage 4A, 17 (20.7%) with stage 4B, and 9 (29.0%) with stage 4C. In a multivariate analysis, histological sub-classification of cirrhosis independently predicted LRE occurrence. While patients with stage 4A tended to be at higher risk of LRE occurrence than those with stage 3, patients with stages 4B and 4C had significantly higher risks of LRE occurrence, with hazard ratios of 6.158 (p=0.016) and 8.945 (p=0.004), respectively. Conclusions: Histological sub-classification of cirrhosis using the Laennec system can be used to assess the risk of LRE occurrence among patients with cirrhosis. Our study provides a solid basis for further studies of non-invasive methods for monitoring the risk of LRE occurrence and will help physicians to establish optimum treatment strategies.
Minimum permanents on two faces of the polytope of doubly stochastic matrices
Pula, K.,Song, S.Z.,Wanless, I.M. North Holland [etc.] 2011 Linear algebra and its applications Vol.434 No.1
We consider the minimum permanents and minimising matrices on the faces of the polytope of doubly stochastic matrices whose nonzero entries coincide with those of, respectively,U<SUB>m,n</SUB>=I<SUB>n</SUB>J<SUB>n,m</SUB>J<SUB>m,n</SUB>0<SUB>m</SUB>andV<SUB>m,n</SUB>=I<SUB>n</SUB>J<SUB>n,m</SUB>J<SUB>m,n</SUB>J<SUB>m,m</SUB>. Here J<SUB>r,s</SUB> denotes the rxs matrix all of whose entries are 1, I<SUB>n</SUB> is the identity matrix of order n and 0<SUB>m</SUB> is the mxm zero matrix. We conjecture that V<SUB>m,n</SUB> is cohesive but not barycentric for 1<n<m+m and that it is not cohesive for n≥m+m. We prove that it is cohesive for 1<n<m+m and not cohesive for n≥2m and confirm the conjecture computationally for n<2m≤200. We also show that U<SUB>m,n</SUB> is barycentric.