Analysis of the relationship between lifestyle habits and glycosylated hemoglobin control based on data from a Health Management Plan

Ya-Chun Wang,Chi Wang,Ping-Wen Shih,Pei-Ling Tang 대한지역사회영양학회 2020 Nutrition Research and Practice Vol.14 No.3

BACKGROUND/OBJECTIVES: Type 2 Diabetes mellitus (T2DM) is a hereditary disease that is also strongly dependent on environmental factors, lifestyles, and dietary habits. This study explored the relationship between lifestyle habits and glycosylated hemoglobin management in T2DM patients to provide empirical outcomes to improve T2DM management and patient health literacy. SUBJECTS/METHODS: This study enrolled 349 diabetic patients with more than 5 care visits to a Diabetes Mellitus care network under the Health Management Plan led by Taiwan Department of Health (DOH). Based on relevant literature, an Outpatient Record Form of Diabetes Mellitus Care was designed and lipid profile tests were conducted for data collection and analysis. RESULTS: When modeling the data, the results showed that the odds for HbA1c > 7.5% in T2DM patients duration over 10 years was 3.785 (P = 0.002) times that in patients with disease duration of fewer than 3 years. The odds of HbA1c > 7.5% in illiterate patients was 3.128 (P = 0.039) times that in patients with senior high school education or above. The odds of HbA1c > 7.5% in patients with other chronic illness was 2.207 (P = 0.019) times that in participants without chronic illness. Among 5 beneficial lifestyle habits, the odds of HbA1c > 7.5% in patients with 2 or 3 good habits were 3.243 (P = 0.003) and 3.424 (P = 0.001) times that in patients with more than 3 good habits, respectively. CONCLUSION: This empirical outcome shows that maintaining a good lifestyle improves T2DM management and patients" knowledge, motivation, and ability to use health information. Patients with longer disease duration, education, or good lifestyle habits had optimal HbA1c management than those in patients who did not. Thus, effective self-management and precaution in daily life and improved health literacy of diabetic patients are necessary to increase the quality of T2DM care.

Angelica Sinensis Polysaccharide Induces Erythroid Differentiation of Human Chronic Myelogenous Leukemia K562 Cells

Wang, Lu,Jiang, Rong,Song, Shu-Dan,Hua, Zi-Sen,Wang, Jian-Wei,Wang, Ya-Ping Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Leukemia is a clonal disorder with blocked normal differentiation and cell death of hematopoietic progenitor cells. Traditional modalities with most used radiation and chemotherapy are nonspecific and toxic which cause adverse effects on normal cells. Differentiation inducing therapy forcing malignant cells to undergo terminal differentiation has been proven to be a promising strategy. However, there is still scarce of potent differentiation inducing agents. We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), has potential differentiation inducing activity in human chronic erythro-megakaryoblastic leukemia K562 cells. MTT assays and flow cytometric analysis demonstrated that ASP inhibited K562 cell proliferation and arrested the cell cycle at the G0/G1 phase. ASP also triggered K562 cells to undergo erythroid differentiaton as revealed by morphological changes, intensive benzidine staining and hemoglobin colorimetric reaction, as well as increased expression of glycophorin A (GPA) protein. ASP induced redistribution of STAT5 protein from the cytoplasm to the nucleus. Western blotting analysis further identified that ASP markedly sensitized K562 cells to exogenous erythropoietin (EPO) by activating EPO-induced JAK2/STAT5 tyrosine phosphorylation, thus augmenting the EPO-mediated JAK2/STAT5 signaling pathway. On the basis of these findings, we propose that ASP might be developed as a potential candidate for chronic myelogenous leukemia inducing differentiation treatment.

Diagnosis on improved electrocatalytic activity of La₂Ni_0.8Cu_0.2O_4+δ electrodes towards oxygen reduction reaction

Wang, Ya-Ping,Xu, Qing,Huang, Duan-Ping,Zhao, Kai,Chen, Min,Kim, Bok-Hee Elsevier 2017 APPLIED SURFACE SCIENCE - Vol.423 No.-

<P><B>Abstract</B></P> <P>La<SUB>2</SUB>Ni<SUB>0.8</SUB>Cu<SUB>0.2</SUB>O<SUB>4+δ</SUB> electrodes with different thicknesses were prepared on Ce<SUB>0.8</SUB>Sm<SUB>0.2</SUB>O<SUB>1.9</SUB> electrolyte using screen printing technique. The electrocatalytic activity of La<SUB>2</SUB>Ni<SUB>0.8</SUB>Cu<SUB>0.2</SUB>O<SUB>4+δ</SUB> electrodes towards oxygen reduction reaction was investigated in comparison with La<SUB>2</SUB>NiO<SUB>4+δ</SUB> electrode. To understand the electrocatalytic activity of the two electrodes, chemical states of constituent elements on the surface of La<SUB>2</SUB>NiO<SUB>4+δ</SUB> and La<SUB>2</SUB>Ni<SUB>0.8</SUB>Cu<SUB>0.2</SUB>O<SUB>4+δ</SUB> were analyzed using X-ray photoelectron spectroscopy technique. La<SUB>2</SUB>Ni<SUB>0.8</SUB>Cu<SUB>0.2</SUB>O<SUB>4+δ</SUB> electrodes sintered at 920°C exhibited improved electrocatalytic activity relative to literature results of the electrodes sintered at higher temperatures (e.g. 1200°C). The Cu doping in La<SUB>2</SUB>NiO<SUB>4+δ</SUB> was validated to be effective in enhancing electrocatalytic activity. The electrocatalytic activity of La<SUB>2</SUB>Ni<SUB>0.8</SUB>Cu<SUB>0.2</SUB>O<SUB>4+δ</SUB> electrodes was found to be dependent on their thickness. Optimal electrocatalytic activity was achieved for the electrode with a thickness of 10μm, showing a polarization resistance of 0.13Ω cm<SUP>2</SUP> at 800°C. The effects of Cu doping and electrode thickness were diagnosed with respect to contributions of involved electrode reaction steps. The results of this work underscore that the electrocatalytic activity of La<SUB>2</SUB>Ni<SUB>0.8</SUB>Cu<SUB>0.2</SUB>O<SUB>4+δ</SUB> electrodes is dictated by dissociative adsorption process of molecular oxygen on the surface.</P> <P><B>Highlights</B></P> <P> <UL> <LI> LNC electrodes achieved improved electrocatalytic activity than literature results. </LI> <LI> The electrocatalytic activity of LNC electrodes is higher than LN electrode. </LI> <LI> The electrocatalytic activity of LNC electrodes is dependent on thickness. </LI> <LI> The optimal electrode polarization resistance of LNC is 0.13Ω cm<SUP>2</SUP> at 800°C. </LI> <LI> The effects of Cu doping and electrode thickness have been explained. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis

Wang, Chao,Ma, Hong-Xi,Jin, Mei-Shan,Zou, Ya-Bin,Teng, Yong-Liang,Tian, Zhuang,Wang, Hai-Ying,Wang, Yin-Ping,Duan, Xiu-Mei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion and metastasis of various tumors. Extra-gastrointestinal stromal tumors (EGISTs) are rare neoplasms. This study was performed to assess MMP-2 and MMP-9 expression in EGIST tissue samples for association with clinicopathological data from the patients. Twenty-one surgical EGIST tissue specimens were collected for analysis of MMP-2 and MMP-9 expression using immunohistochemistry. MMP-2 and MMP-9 proteins were expressed in all of the epithelial cell types of EGISTs, whereas they were only expressed in 75% of the spindle cell type, although there was no statistically significant difference (p>0.05). Expression of MMP-2 and MMP-9 proteins was associated with tumor size, mitotic rate, tumor necrosis, and distant metastasis (p<0.05). MMP-2 expression was linked with MMP-9 levels (p<0.05). However, there was no correlation between MMP-9 expression and age, sex, primary site, or cell morphology in any of these 21 EGIST patients (p>0.05). Moreover, expression of MMP-2 and MMP-9 proteins increased with the degree of EGIST risk. This study provided evidence of an association of MMP-2 and MMP-9 expression with advanced EGIST behavior.

Survey on electrochemical properties of La_2−xSr_xNiO_4±δ (x = 0.2 and 0.8, δ > 0) cathodes related with structural stability under cathodic polarization conditions

Wang, Ya-Ping,Xu, Qing,Huang, Duan-Ping,Zhao, Kai,Chen, Min,Kim, Bok-Hee Elsevier 2017 International journal of hydrogen energy Vol.42 No.9

<P><B>Abstract</B></P> <P>In view of utilization as cathodes for intermediate temperature solid oxide fuel cells (SOFCs), the La<SUB>2−x</SUB>Sr<SUB>x</SUB>NiO<SUB>4±δ</SUB> (x = 0.2 and 0.8, δ > 0) series of compounds were evaluated with respect to their electrical conducting, thermomechanical and electrochemical properties. On the one hand, La<SUB>1.2</SUB>Sr<SUB>0.8</SUB>NiO<SUB>4−δ</SUB> exhibits a higher electrical conductivity (>180 S cm<SUP>−1</SUP> in the temperature range 600–800 °C) and a lower electrode polarization under open-circuit voltage conditions (∼0.12 Ω cm<SUP>2</SUP> at 800 °C) than La<SUB>1.8</SUB>Sr<SUB>0.2</SUB>NiO<SUB>4+δ</SUB>, together with a suitable thermal expansion coefficient (13.8 × 10<SUP>−6</SUP> K<SUP>−1</SUP> averaged between 50 and 1000 °C). On the other hand, the structure and electrochemical properties of La<SUB>1.2</SUB>Sr<SUB>0.8</SUB>NiO<SUB>4−δ</SUB> electrode were obviously changed after being subjected to cathodic polarization. The cathodically polarized La<SUB>1.2</SUB>Sr<SUB>0.8</SUB>NiO<SUB>4−δ</SUB> electrode showed an aggregation of strontium oxide onto the surface, concomitant with a degradation of electrochemical properties. By contrast, the structure and electrochemical properties of La<SUB>1.8</SUB>Sr<SUB>0.2</SUB>NiO<SUB>4+δ</SUB> electrode before and after cathodic polarization were basically unvaried. The disparate changes in structure and electrochemical properties of the two electrodes were interpreted in terms of their differing peculiarities in oxygen nonstoichiometry. The results of this work highlight the importance of strontium content and thereby oxygen nonstoichiometry of La<SUB>1−x</SUB>Sr<SUB>x</SUB>NiO<SUB>4±δ</SUB> electrodes to their structural stability under cathodic polarization conditions, which is a critical point to be used as cathodes in SOFCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> LSN2 and LSN8 were evaluated in view of cathode utilization for IT-SOFCs. </LI> <LI> LSN8 exhibits higher electrical conductivity and catalytic activity than LSN2. </LI> <LI> Cathodically polarized LSN8 electrode undergoes structure and property changes. </LI> <LI> The structure and properties of polarized LSN2 electrode remains unchanged. </LI> <LI> The disparate behaviors of the two electrodes were interpreted. </LI> </UL> </P>

중국 주식시장의 모멘텀 효과 검증

왕아평 ( Ya Ping Wang ),하연정 ( Yeon Jeong Ha ) 국제지역학회 2015 국제지역연구 Vol.19 No.3

본 연구는 중국 주식시장의 장기적인 자료를 이용하여 중국 시장의 모멘텀 효과를 검증하였다. Jegadeesh and Titman(1993) 등 많은 연구는 미국 주식시장의 모멘텀 효과가 존재함을 보였지만, Chui et al.(2010)은 이러한 모멘텀 효과가 아시아 국가에서는 존재하지 않음을 보였다. 이에 본 연구는 중국 주식시장의 거래소별, 기간별, 월별, 규모별로 나누고, 다양한 포트폴리오 구성 기간을 이용하여 모멘텀 효과를 검증하였다. 분석 결과는 다음과 같다. 첫째, 규모가 작은 주식이 거래되는 심천 거래소에서 모멘텀 효과가 존재하였다. 둘째, 2007년 이전 기간에는 모멘텀 효과가 전혀 존재하지 않았지만, 2008년 이후 모멘텀 효과가 약하게 발생하기 시작하였다. 셋째, 규모를 고려하여 재검증한 결과, 2008년 이후 규모가 작은 주식을 대상으로 모멘텀 효과가 존재함을 보여, 최근 중국 시장에서 모멘텀 효과가 바뀌었음을 확인하였다. 본 연구는 최근 중국 주식시장의 변화가 모멘텀 효과에 영향을 미쳤음을 보여주었다는 데에 의미를 가진다. A number of studies starting with Jegadeesh and Titman (1993) clarify the momentum effect in United States. However, Chui et al. (2010) find that momentum effect disappears in Asia countries. This paper revisits the momentum effect in Chinese stock markets using a long historical return data. The results are as follows. First, we find the momentum effect in the Shenzhen Stock Exchange that trades small firm`s stocks. Second, from 1991 to 2007, we fail to find the momentum effect, but since 2008, we find the effect. Last, when we consider the firm size to examine the momentum effect, the effect exists only in small firms since 2008. So, we conclude that the momentum effect is present in Chinese stock markets recently.

RTN4 3'-UTR Insertion/Deletion Polymorphism and Susceptibility to Non-Small Cell Lung Cancer in Chinese Han Population

Lu, De-Yi,Mao, Xu-Hua,Zhou, Ying-Hui,Yan, Xiao-Long,Wang, Wei-Ping,Zheng, Ya-Biao,Xiao, Juan-Juan,Zhang, Ping,Wang, Jian-Guo,Ashwani, Neetika,Ding, Wei-Liang,Jiang, Hua,Shang, Yan,Wang, Ming-Hua Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Nogo protein, encoded by gene reticulon-4 (RTN4), includes three major isoforms by different splicing, named Nogo-A Nogo-B and Nogo-C. Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. RTN4 single nucleotide polymorphisms (SNPs) can influence the efficiency of transcription and translation thus being related with an individual's predisposition to cancer. The CAA insertion/deletion polymorphism (rs34917480) within RTN4 3'-UTR has been reported to be associated with many cancer types. In order to investigate the relationship between this polymorphism and susceptibility to non-small cell lung cancer (NSCLC) in the Chinese population, we conducted the present case-control study including 411 NSCLC patients and 471 unrelated healthy controls. The genotype distributions were significantly different between cases and controls (p=0.014). We found that the del allele could significantly increase NSCLC risk (ins/ins vs ins/del: p=0.007, OR 1.46, 95%CI=1.11-1.93; dominant model: p=0.004, OR 1.47, 95%CI=1.13-1.92 and allele model: p=0.008, OR 1.35, 95%CI=1.08-1.67). This association was stronger in participants over 60 years old, males and smokers. We therefore conclude that the CAA insertion/deletion polymorphism (rs34917480) contributes to non-small cell lung cancer risk in Chinese population. Age, sex and environmental exposure are also related to carcinogenic effects of rs34917480.

Hepatic Re-resection Versus Transarterial Chemoembolization for the Treatment of Recurrent Hepatocellular Carcinoma after Initial Resection: a Systematic Review and Meta-analysis

Wang, Di-Ya,Liu, Lei,Qi, Xing-Shun,Su, Chun-Ping,Chen, Xue,Liu, Xu,Chen, Jiang,Li, Hong-Yu,Guo, Xiao-Zhong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Background: A systematic review and meta-analysis were performed to compare the post-recurrence survival with hepatic re-resection versus transarterial chemoembolization (TACE) for recurrent hepatocellular carcinoma (HCC) after initial resection. Materials and Methods: All relevant papers were searched via PubMed, EMBASE, and Cochrane Library databases. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Subgroup analysis was performed according to country. Sensitivity analysis was performed in studies which clearly reported the recurrent regions, in moderate/high-quality studies, in studies published in full-text form, and in studies published after 2005. Results: In total, twelve papers were included in our study. Five and seven of them were of moderate- and poor-quality, respectively. The overall meta-analysis demonstrated a statistically significantly higher post-recurrence survival in the hepatic re-resection group than in those undergoing TACE (HR=0.64, 95%CI=0.52-0.79, P<0.0001). Heterogeneity was statistically significant and statistical significance remained in the subgroup analysis. Sensitivity analyses were also consistent with the overall analysis. Conclusions: Hepatic re-resection might provide a better post-recurrence survival than TACE for recurrent HCC after initial resection. However, considering the low quality of published studies and the potential bias of treatment selection, further randomized trials should be warranted to confirm these findings.

Comparative Evaluation of Hepatoprotective Activities of Geniposide, Crocins and Crocetin by CCl4-Induced liver Injury in Mice

( Ping Chen ),( Yang Chen ),( Ya Rong Wang ),( Shi Ning Cai ),( Liang Deng ),( Jia Liu ),( Hao Zhang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2

Iridoid glycosides (mainly geniposide) and crocetin derivatives (crocins) are the two major active constituents in Gardenia jasminoides Ellis. In the present study, geniposide, crocins, crocin-1 and crocetin were separated from gardenia chromatographically. Then, mice were orally administrated with geniposide (400 mg/kg b.w.), crocins (400 mg/kg b.w.), crocin-1 (400 mg/kg b.w.) and crocetin (140 mg/kg b.w.) once daily for 7 days with CCl4. Hepatoprotective properties were evaluated by biochemical parameters: Administration of geniposide, crocins, crocin-1and crocetin significantly lowered serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) levels in CCl4-treated mice. The reduced glutathione (GSH) levels and antioxidant enzymes (SOD and CAT) activities were also increased by geniposide, crocins, crocin-1 and crocetin. Histopathological examination of livers showed that these components reduced deformability, irregular arrangement and rupture of hepatocyte in CCl4-treated mice. These biochemical results and liver histopathological assessment demonstrated that geniposide, crocetin derivatives and crocetin show comparative beneficial effects on CCl4-induced liver damage via induction of antioxidant defense. Therefore, contents of geniposide and crocetin derivatives should be both considered for hepatoprotective efficacy of Gardenia jasminoides Ellis.

Influence of the Incorporation of Aluminum on the Optical Properties of MCM-41

Ya-Ping Hsieh,Yang-Fang Chen,Ai-Qin Wang,Chi-Te Liang,Chung-Yuan Mou,Ji-Wei Chen 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.6

Different ratios of aluminum were incorporated into MCM-41. PL measurements revealed a blue shift and an enhancement in intensity by 2 orders of magnitude as the Si : Al ratio was decreased to 14. By comparing the PL and the photoluminescence excitation (PLE) spectra of aluminosilicate MCM-41 to silica MCM-41 and to published reports on similar materials, we are able to identify the origin of the photoluminescence enhancement.