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Wang, Zhi-Jun,Wang, Mao-Qiang,Duan, Feng,Song, Peng,Liu, Feng-Yong,Wang, Yan,Yan, Jie-Yu,Li, Kai,Yuan, Kai Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Objective: This work aimed to evaluate the safety and clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with c-arm cone-beam CT guided synchronous radiofrequency ablation (RFA) in treatment of large hepatocellular carcinoma (HCC). Methods: 21 patients with large HCC were studied from January 2010 to March 2012. TACE combined with synchronous C-arm cone-beam CT guided RFA were performed on a total of 25 lesions. Conventional imaging examination (CEUS, enhanced CT or MRI) and AFP detection were regularly conducted to evaluate the technical success rate of combined treatment, complications, treatment response, time without disease recurrence and survival rate. Results: The technical success rate of combined treatment was 100%, without any significant complication. After 1 month, there were 19 cases with complete response and 2 cases with partial response, with an complete response rate of 90.4% (19/21) and a clinical effective rate of 100% (21/21). The complete response rates of single nodular lesions (100%, 17/17) was significantly higher than that of multiple nodular lesions (50%, 2/4) (P<0. 05). During 2 to 28 months of follow-up, in 19 cases with complete response, the average time without disease recurrence was $10.8{\pm}6$ months. The total survival rates of 6, 12 and 18 months in 21 patients were 100%, respectively. Conclusion: TACE combined with synchronous C-arm CT guided RFA is safe and effective for treatment of large HCC. The treatment efficacy for single nodular lesion is better than that for multiple nodular lesions.
Geometric Optimization of a Mathematical Model of Radiofrequency Ablation in Hepatic Carcinoma
Wang, Kai-Feng,Pan, Wei,Wang, Fei,Wang, Gao-Feng,Madhava, Pai,Pan, Hong-Ming,Kong, De-Xing,Liu, Xiang-Guan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Radio frequency ablation (RFA) is an effective means of achieving local control of liver cancer. It is a particularly suitable mode of therapy for small and favorably located tumors. However, local progression rates are substantially higher for large tumors (>3.0 cm). In the current study, we report on a mathematical model based on geometric optimization to treat large liver tumors. A database of mathematical models relevant to the configuration of liver cancer was also established. The specific placement of electrodes and the frequency of ablation were also optimized. In addition, three types of liver cancer lesion were simulated by computer guidance incorporating mathematical models. This approach can be expected to provide a more effective and rationale mechanism for employing RFA in the therapy of hepatic carcinoma.
Kai Wang,Lihua Han,Na Wang,Yiming Wang,Jingfeng Wang 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.5
The effect of sialoglycoprotein isolated from Gadous morhua eggs (Gm-SGP) on ovariectomized (OVX) induced osteoporosis, which is characterized by high bone turnover activity was investigated. Results revealed that Gm-SGP significantly increased bone mineral density, enhanced bone biomechanical properties and repaired the microstructure of the trabecular bone. Also, the treatment with Gm-SGP remarkably decreased biochemical marker contents or activities, such as serum BALP, PICP, BMP-2, TrACP, Cath-K, urine Ca and P, leading to the reduction in bone turnover. The elevation in the rate of bone formative process contributed in the increase of bone turnover. Both BMP-2/Smads and Wnt/b-catenin signaling pathways played an important role in osteogenesis. Gm-SGP suppressed the key factors expression in these two pathways such as BMP-2, Smad1, Smad4, Lrp-5b, Runx2, Osx, ALP, Col1, OCN and b-catenin. These findings might provide some theoretical basis for the application of Gm-SGP as a potential anti-osteoporotic drug or as functional food.
Wang, Kai,Wang, Yin-Yan,Ma, Jun,Wang, Jiang-Fei,Li, Shao-Wu,Jiang, Tao,Dai, Jian-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Several molecular markers have been proposed as predictors of outcome in patients with glioblastomas. We investigated the prognostic significance of $O^6$-methylguanine-DNA methyltransferase (MGMT) promoter methylation and TP53 mutation status dependent on isocitrate dehydrogenase 1 (IDH1) mutation in glioblastoma patients. A cohort of 78 patients with histologically confirmed glioblastomas treated with radiation therapy and chemotherapy were reviewed retrospectively. We evaluated the prognostic value of MGMT promoter methylation and TP53 mutation status with regard to progression-free survival (PFS) and overall survival (OS). It was revealed that mutations in IDH1, promoter methylation of MGMT, TP53 mutation, age, Karnofsky performance status (KFS), and extension of resection were independent prognostic factors. In patients with an IDH1 mutation, those with an MGMT methylation were associated with longer PFS (p=0.016) and OS (p=0.013). Nevertheless, the presence of TP53 mutation could stratify the PFS and OS of patients with IDH1 wild type (p=0.003 and 0.029 respectively, log-rank). The MGMT promoter methylation and TP53 mutation were associated with a favorable outcome of patients with and without mutant IDH1, respectively. The results indicate that glioblastomas with MGMT methylation or TP53 mutations have improved survival that may be influenced by IDH1 mutation status.
Ceramic coatings on 6061 Al alloys by plasma electrolytic oxidation under different AC voltages
Kai Wang,Young Joo Kim,Yasunori Hayashi,이찬규,구본흔 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.4
Ceramic coatings have been produced on 6061 Al alloy substrates in a weak alkaline-silicon electrolyte under different AC voltage at 60 Hz combined with a 200 V DC voltage for 5 minutes by a plasma electrolytic oxidation process. The surface morphology, composition, structure and microhardness analysis of layers were carried out by an X-ray diffractormetor, optical microscopy, scanning electron microscopy, an energy dispersive X-ray spectrometer and a microhardness tester. Analysis shows that a two-layer structure coating consist of different states of α-Al2O3, β-Al2O3 and γ-Al2O3, where Si concentrates in the hard outer layer, and Cl predominates in the soft internal layer. The influence of deposition AC voltages on the kinetics of coating formation, coating microhardness, the number and size of the discharging channels was investigated.
Antioxidant Phenolic Compounds from Rhizomes of Curculigo crassifolia
Wang, Kai-Jin,Li, Ning 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
A pair of new phenolic glycosides, crassifoside G (5) and isocrassifoside G (6), along with five known phenolic compounds (1-4 and 7), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were established by spectroscopic techniques and chemical methods. Most of the isolated compounds exhibited strong antioxidant activity in the 1, 1-diphenyl-2-picryldydrazyl (DPPH) radical scavenging assay.
Wang, Kai,Byeon, Sang-Sik,Kim, Geun-Woo,Park, Keun-Young,Ahmed, Faheem,Koo, Bon-Heun Materials Research Society of Korea 2012 한국재료학회지 Vol.22 No.3
In this work, AlON-$Al_2O_3$ coatings were prepared on Al2021 alloy by the electrolytic plasma processing (EPP) method. The experimental electrolytes include: 2 g/l NaOH as the electrolytic conductive agent, 10 g/l $Na_2AlO_2$ as the alumina formative agent, and 0.5 g/l $NaNO_2$, $NaNO_3$, and $NH_4NO_3$ as the nitride inducing agents. The effects of different nitrogen inducing agents were studied by a combined compositional and structural analyses of the ceramic coatings carried out by Xray diffractometry (XRD) and scanning electron microscopy (SEM) for the specimens EPP-treated at room temperature for 15 min under a hybrid voltage of 260 DC along with an AC 50 Hz power supply (200 V). Microhardness tests and wear tests were carried out to correlate the evolution of the microstructure and the resulting mechanical properties. Potentiodynamic polarizations and immersion corrosion tests were carried out in 3.5wt% NaCl water solutions under static conditions in order to evaluate the corrosion behavior of the coated samples. The results demonstrate that $NaNO_2$ is proven to be a good nitrogen inducing agent to produce high quality AlON-$Al_2O_3$ ceramic coatings.
Online Adaptive Optimal Tracking Control of Nonholonomic Mobile Robot
Kai Wang,Yingmin Jia,Junping Du,Jun Zhang 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
A velocity control law is developed for the kinematic steering system of nonholonomic mobile robot to track a reference trajectory not only to make the posture error asymptotically stable but also considered optimality based on a pre-defined cost function. In order to make the cost function finite, we transformed the tracking problem into a regulation problem by redefining system states and inputs. The proposed online and forward-in-time policy iteration (PI) algorithm based on approximate dynamic programming (ADP) to solve the continuous-time(CT) optimal control problem with infinite horizon cost by solving of Hamilton-Jacobi-Bellman (HJB) equation. This method learns online in real-time to approximate the cost function by using a single neural networks (NNs), and then the near optimal control policy can be computed directly according to the cost function, which removes the action network appearing in the ordinary ADP methods. Simulation results are provided to demonstrate the effectiveness of the proposed approach.
Antioxidant Phenolic Compounds from Rhizomes of Curculigo crassifolia
Kai-Jin Wang,Ning Li 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
A pair of new phenolic glycosides, crassifoside G (5) and isocrassifoside G (6), along with five known phenolic compounds (1-4 and 7), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were established by spectroscopic techniques and chemical methods. Most of the isolated compounds exhibited strong antioxidant activity in the 1, 1-diphenyl-2-picryldydrazyl (DPPH) radical scavenging assay.