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Wang Hui-Ching,Moi Sin-Hua,Chan Leong-Perng,Wu Chun-Chieh,Du Jeng-Shiun,Liu Pei-Lin,Chou Meng-Chun,Wu Che-Wei,Huang Chih-Jen,Hsiao Hui-Hua,Pan Mei-Ren,Chen Li-Tzong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature (RMS) and chromatin remodeling mutation signature (CRMS) were explored to predict the risk of relapse in patients with HNSC treated with concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy. Patients in the high RMS and CRMS groups showed significantly shorter relapse-free survival than those in the low RMS and CRMS groups, respectively (p < 0.001 and p = 0.006). Multivariate Cox regression analysis showed that extranodal extension, CCRT response, and three somatic mutation profiles (TMB, RMS, and CRMS) were independent risk predictors for HNSC relapse. The predictive nomogram showed satisfactory performance in predicting relapse-free survival in patients with HNSC treated with CCRT.
SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells
Wang, Hong-Ling,Lu, Ren-Quan,Xie, Su-Hong,Zheng, Hui,Wen, Xue-Mei,Gao, Xiang,Guo, Lin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction. There is some evidence that SIRT7 may function as a tumor trigger for human malignancy. Here, we aimed to explore the biological function of SIRT7 in ovarian carcinoma cells and its potential mechanism. Materials and Methods: Expression of SIRT7 in ovarian cancer cell lines was detected by western blotting. Transduced cell lines with SIRT7 knockdown or overexpression were constructed. Cell viability, cologenic, apoptosis-associated and motility assays were performed to elucidate the biological function of SIRT7 in ovarian cancer cells. Results: SIRT7 demonstrated a higher level in ovarian cancer cell lines compared with normal cells. On the one hand, down-regulation of SIRT7 significantly reduced ovarian cancer cell growth, repressed colony formation and increased cancer cell apoptosis; on the other hand, up-regulation promoted the migration of cancer cells. Additionally, repression of SIRT7 also induced change in apoptosis-related molecules and subunits of the NF-${\kappa}B$ family. Conclusions: In the present study, our data indicated that SIRT7 might play a role of oncogene in ovarian malignancy and be a potential therapeutic target.
Wang, Shao-Ming,Zhang, Shao-Kai,Pan, Xiong-Fei,Ren, Ze-Fang,Yang, Chun-Xia,Wang, Zeng-Zhen,Gao, Xiao-Hong,Li, Man,Zheng, Quan-Qing,Ma, Wei,Zhao, Fang-Hui,Qiao, You-Lin,Sivasubramaniam, Priya Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: College students are recommended as the target groups for catch-up human papillomavirus (HPV) vaccination. Systematical exploration of awareness, acceptability, and decision-making factors of HPV vaccination among Chinese college students has been limited. Materials and Methods: A multi-center survey was conducted in mainland China between November 2011 and May 2012. College students aged 18-22 years were stratified by their grade, gender, and major for sampling. Socio-demographic and HPV-related information such as knowledge, perceptions, acceptability, and attitudes were collected through a questionnaire. Results: A total of 3,497 undergraduates completed the questionnaire, among which 1,686 were males. The acceptability of the HPV vaccine was high (70.8%). Undergraduates from high-level universities, at lower grade, or with greater prior knowledge of HPV vaccines showed higher acceptability of HPV vaccination ($p_{trend}$ <0.001). Additionally, undergraduates with vaccination experience outside the National Expanded Program on Immunization (OR=1.29; 95%CI: 1.10-1.51) or fear of HPV-related diseases (OR=2.79; 95%CI: 2.28-3.41) were more willing to accept HPV vaccination. General knowledge of HPV vaccine was low among undergraduates, and safety was a major concern (71.05%). The majority of students wished to pay less than 300RMB for HPV vaccine and chose the Chinese Center for Disease Control and Prevention as the most appropriate venue for vaccination. Conclusions: Although most undergraduates demonstrate positive attitudes towards HPV vaccination, challenges pertaining to introduction exist in China. Corresponding proactive education and governmental subsidy to do so are urgently needed by this age-group population. Suggestions and potential strategies indicated may help shape the future HPV vaccination program in China.
Wang, Hui-Ling,Ren, Yan-Fang,Yang, Jun,Qin, Rui-Ying,Zhai, Kai-Hua Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
The standard surgery for early-stage endometrial cancer is total abdominal hysterectomy (TAH), while total laparoscopic hysterectomy (TLH) is less invasive and assumed to be associated with lower morbidity. This meta-analysis was performed to investigate the effects of TLH versus TAH in women with early-stage endometrial cancer. We searched the PubMed, EMBASE, CBM and Cochrane Review databases for randomized trials assessing the effects of TLH versus TAH in women with early-stage endometrial cancer. The relative risks (RR) with 95% confidence intervals (CIs) from each study were pooled using meta-analysis. In our study, 9 randomized trials with a total of 1,263 patients were included. Meta-analyses showed that TLH was associated with lower risks of major complications (RR = 0.53, 95%CI 0.29-0.98, P = 0.042), total complications (RR = 0.59, 95%CI 0.42-0.82, P = 0.002) and postoperative complications (RR = 0.57, 95%CI 0.40-0.83, P = 0.003). However, there were no obvious differences in risks of intra-operative complications (RR = 0.98, 95%CI 0.62-1.55, P = 0.919) and mortality (RR = 0.96, 95%CI 0.66-1.40, P = 0.835). In conclusion, our results provide new evidence of a benefit for TLH over TAH in terms of major complications, total complications and postoperative complications in endometrial cancer patients.
Jianzhi Wang,Yu Luo,Tong Xu,Ziyi Guo,Guopeng Chen,Yuchen Ren,Yanan Xue,Ning Cai,Hui Li,Faquan Yu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-
The development of low-cost and highly efficient electrocatalysts for oxygen evolution reaction (OER)with good conductivity, high specific surface area and abundant oxygen vacancies is of great significancefor the future renewable energy conversion and storage system. Herein, Ag doped NiMoO4 materials onthe Ni foam (NiMoO4/Ag/NF) with rich oxygen vacancies were successfully prepared by hydrothermalstrategy and layer by layer assembly method. The Ag ions are doped in-situ to promote electron transferand compensate for the poor conductivity of metal oxides. The suitable air annealing treatment is used tocreate rich oxygen vacancies. The high specific surface area and one-dimensional characteristics of thecross mesoporous nanorod skeleton are responsible for the increased exposure of active centers andthe rapid charge transfer behavior. The NiMoO4/Ag/NF exhibits high activity for OER in alkaline solution(an overpotential of 275 mV at the current density of 20 mA cm2) and low Tafel slope (53.67 mV dec1),and a satisfying durability in 1.0 M KOH. This study provides an effective method for the preparation ofAg doped one-dimensional nanomaterials with excellent OER catalytic performance and electrochemicalstability.
Xi Wang,Miao-Wang Hao,Ke Dong,Fang Lin,Ji-Hong Ren,Hui-Zhong Zhang 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.9
Epigallocatechin-3-gallate (EGCG), the major component of green tea polyphenol, has potent efficiency to prevent the growth of a variety of cancer cells. As a novel anticancer agent for treatment of cancers, EGCG is promising and the mechanism has not been fully understood. Laryngeal squamous cell carcinoma (LSCC) is one common tumor in head and neck cancers. In the present study, we assess the effects of EGCG on LSCC cell line Hep-2, and their possible involvement in EGCG-induced apoptosis. The result showed that treatment of Hep-2 cells with EGCG decreased the cell viability, inhibited the growth and proliferation, induced apoptosis and increased the activity of caspase-3 in a dose-dependent manner. Furthermore, we found that EGCG-treatment repressed telomerase activity effectively in a concentrationdependent manner. The combined results show that EGCG induced apoptosis in Hep-2 cells via inhibiting the telomerase activity.
Chemical constituents from Inula wissmanniana and their anti-inflammatory activities
Chunhui Wang,Xufeng Zhang,Panlei Wei,Xiangrong Cheng,Jie Ren,Shi Kai Yan,Wei Dong Zhang,Hui Zi Jin 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.12
Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol (1) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol (2), onenew flavonolignan 23-o-acetylsilychristin A (3), and onenew thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid (4), along with 13 known compounds,including ten flavonolignans (5–14) and three thymolderivatives (15–17) were isolated from the aerial part ofInula wissmanniana. The structures of new compoundswere elucidated by detailed spectroscopic analysis,including HRESIMS and 2D-NMR spectroscopic data. Allthe compounds were isolated from this plant for the firsttime. The anti-inflammatory activities of the compoundswere tested against LPS-induced NO production in RAW264.7 macrophages.
Yanyan Ren,Le Yang,LIUDING WANG,Hui Xing,HONGJING WU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.8
Low-density Fe-doped ordered mesoporous carbon (CMK-3)-silica (SBA-15) nanocomposites with different Fe contents have been prepared by a catalytic carbonization procedure followed by high-temperature calcination in N2. From field emission-scanning electron microscope (FE-SEM) and high resolution-transmission electron microscope (HR-TEM) images, it can be concluded that CMK-3 particles are dispersed homogeneously into a silica matrix and form a novel, special and interesting composite nanostructure. The metal species (~18 nm) are dispersed on the surface of frameworks during the catalytic carbonization procedure and endow a magnetic property to the carbon–silica nanocomposites. The optimal reflection loss (RL) calculated from the measured permittivity and permeability is -19 dB at 17.2 GHz for an absorber thickness of 2.00 mm. Moreover, the electromagnetic (EM) wave absorption less than -10 dB is found to exceed 5.76 GHz as the layer thickness is 2.37 mm. The permittivity dispersion behaviors have been explained based on the Cole–Cole model and the conductivity contribution model. A new simple empirical model was also supposed to find the fitted curves of the multi-resonance imaginary permeability spectra of the composites. The EM wave can hardly be reflected on the absorber surface because of a better match between dielectric loss and magnetic loss, which originates from the combination of dielectric carbon–silica and magnetic Fe species.
Yanyan Ren,Hongfeng Li,Guanglei Wu,Le Yang,Chenhui Zheng,LIUDING WANG,Fang Ren,Hui Xing,HONGJING WU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.2
Al/Fe/Co doped ordered mesoporous carbon (OMC) composites have been synthesized by a facile method, and the influence of dopant on the electromagnetic (EM) and microwave absorption properties was investigated in the frequency range of 2–18 GHz. Compared with Fe/Co– OMC composites, the Al–OMC nanocomposite played a great role in adjusting values and frequency dependence of complex permittivity, which gives rise to significant improved microwave absorption and reduced thickness of the corresponding paraffin wax composites. Reflection loss (RL) values less than -5 dB and -10 dB were obtained in the frequency range of 9.2–18 GHz and 10.7–14.7 GHz with a single thickness of 2.00 mm, respectively. Such enhanced EM wave absorption property of the Al–OMC/paraffin wax composite was ascribed to its superior impedance matching characteristic. Thin thickness, broadband absorption microwave absorbers with Al doped OMC nanocomposites were obtained.