http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Waickman, Adam T. (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Waickman, Adam T.,Ligons, Davinna L.,Hwang, SuJin,Park, Joo-Young,Lazarevic, Vanja,Sato, Noriko,Hong, Changwan,Park, Jung-Hyun Elsevier 2017 Cytokine Vol.99 No.-
<P><B>Abstract</B></P> <P>T cells are both producers and consumers of cytokines, and autocrine cytokine signaling plays a critical role in T cell immunity. IL-15 is a homeostatic cytokine for T cells that also controls inflammatory immune responses. An autocrine role of T cell-derived IL-15, however, remains unclear. Here we examined IL-15 expression and signaling upon effector T cell differentiation in mice, and, surprisingly, found that CD4 T cells did not express IL-15. CD4 T cells lacked <I>Il15</I> gene reporter activity, did not contain IL-15 transcripts, and did not produce IL-15Rα, the proprietary IL-15 receptor required for IL-15 <I>trans</I>-presentation. Moreover, IL-15 failed to inhibit Th17 cell differentiation and failed to generate Foxp3<SUP>+</SUP> Treg cells <I>in vitro</I>. IL-2, which utilizes the same IL-2Rβ/γc receptor complex, however, successfully did so. Exogenous IL-15 only exerted bioactivity and controlled T cell differentiation when it was <I>trans</I>-presented by IL-15Rα. Consequently, IL-15Rα-bound IL-15, but not free IL-15, suppressed Th17 cell differentiation and induced Treg cell generation. Collectively, these results reveal the absence of an IL-15 autocrine loop in CD4 T cells and strongly suggest that IL-15 <I>trans</I>-presentation by non-CD4 T cells is the primary mechanism via which IL-15 controls CD4 effector T cell differentiation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Unlike most other γc cytokines, IL-15 is not produced by activated CD4 T cells. </LI> <LI> Free IL-15 phosphorylates STAT5 but does not affect CD4 T cell differentiation. </LI> <LI> IL-15Rα-bound IL-15, but not free IL-15, suppresses Th17 cell generation. </LI> <LI> IL-15 <I>trans</I>-presentation is required to control CD4 effector T cell differentiation. </LI> </UL> </P>
-
Hong, C.,Luckey, Megan A.,Ligons, Davinna L.,Waickman, Adam T.,Park, J.Y.,Kim, Grace Y.,Keller, Hilary R.,Etzensperger, R.,Tai, X.,Lazarevic, V.,Feigenbaum, L.,Catalfamo, M.,Walsh, Scott T.R.,Park, J. Cell Press 2014 Immunity Vol.40 No.6
The common γ-chain (γc) plays a central role in signaling by IL-2 and other γc-dependent cytokines. Here we report that activated T cells produce an alternatively spliced form of γc mRNA that results in protein expression and secretion of the γc extracellular domain. The soluble form of γc (sγc) is present in serum and directly binds to IL-2Rβ and IL-7Rα proteins on T cells to inhibit cytokine signaling and promote inflammation. sγc suppressed IL-7 signaling to impair naive T cell survival during homeostasis and exacerbated Th17-cell-mediated inflammation by inhibiting IL-2 signaling upon T cell activation. Reciprocally, the severity of Th17-cell-mediated inflammatory diseases was markedly diminished in mice lacking sγc. Thus, sγc expression is a naturally occurring immunomodulator that regulates γc cytokine signaling and controls T cell activation and differentiation.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
