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Quasi 3D ECE imaging system for study of MHD instabilities in KSTAR.
Yun, G S,Lee, W,Choi, M J,Lee, J,Kim, M,Leem, J,Nam, Y,Choe, G H,Park, H K,Park, H,Woo, D S,Kim, K W,Domier, C W,Luhmann, N C,Ito, N,Mase, A,Lee, S G American Institute of Physics 2014 Review of scientific instruments Vol.85 No.11
<P>A second electron cyclotron emission imaging (ECEI) system has been installed on the KSTAR tokamak, toroidally separated by 1/16th of the torus from the first ECEI system. For the first time, the dynamical evolutions of MHD instabilities from the plasma core to the edge have been visualized in quasi-3D for a wide range of the KSTAR operation (B0 = 1.73.5 T). This flexible diagnostic capability has been realized by substantial improvements in large-aperture quasi-optical microwave components including the development of broad-band polarization rotators for imaging of the fundamental ordinary ECE as well as the usual 2nd harmonic extraordinary ECE.</P>
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer
Lee, K-S,Lee, Y-S,Lee, J-M,Ito, K,Cinghu, S,Kim, J-H,Jang, J-W,Li, Y-H,Goh, Y-M,Chi, X-Z,Wee, H,Lee, H-W,Hosoya, A,Chung, J-H,Jang, J-J,Kundu, J K,Surh, Y-J,Kim, W-J,Ito, Y,Jung, H-S,Bae, S-C Macmillan Publishers Limited 2010 Oncogene Vol.29 No.23
Human lung adenocarcinoma, the most prevalent form of lung cancer, is characterized by many molecular abnormalities. K-ras mutations are associated with the initiation of lung adenocarcinomas, but K-ras-independent mechanisms may also initiate lung tumors. Here, we find that the runt-related transcription factor Runx3 is essential for normal murine lung development and is a tumor suppressor that prevents lung adenocarcinoma. Runx3−/− mice, which die soon after birth, exhibit alveolar hyperplasia. Importantly, Runx3−/− bronchioli exhibit impaired differentiation, as evidenced by the accumulation of epithelial cells containing specific markers for both alveolar (that is SP-B) and bronchiolar (that is CC10) lineages. Runx3−/− epithelial cells also express Bmi1, which supports self-renewal of stem cells. Lung adenomas spontaneously develop in aging Runx3+/− mice (∼18 months after birth) and invariably exhibit reduced levels of Runx3. As K-ras mutations are very rare in these adenomas, Runx3+/− mice provide an animal model for lung tumorigenesis that recapitulates the preneoplastic stage of human lung adenocarcinoma development, which is independent of K-Ras mutation. We conclude that Runx3 is essential for lung epithelial cell differentiation, and that downregulation of Runx3 is causally linked to the preneoplastic stage of lung adenocarcinoma.
Zhou, W.T.,Fujita, M.,Ito, T.,Yamamoto, S. Asian Australasian Association of Animal Productio 1997 Animal Bioscience Vol.10 No.6
This study was conducted to determine the relationships between abdominal temperature (Tabd) and some thermoregulatory responses, such as heat production (HP), heart rate (HR), respiration rate (RR), temperature of external ear tract (Tee), comb surface temperature (Tcs) and shank skin temperature (Tss), for revealing the role of deep body temperature in the thermoregulation of broiler chickens. Tabd was divided into 5 zones of 40-41, 41-42, 42-43, 43-44 and $44-45^{\circ}C$, and maintained for 3 hours in each zone by varying environmental temperature from 11 to $33^{\circ}C$. HP and HR had a greater increase with Tabd above $42.5^{\circ}C$. RR increased markedly with Tabd above $41.5^{\circ}C$, and reached a maximum when Tabd was at $42.5^{\circ}C$, then began to decrease. In addition, HP and HR increased significantly with decrease RR during the decreasing phase of panting. Tcs and Tss changed rapidly with Tabd when Tabd was below $41.5^{\circ}C$, and increased more slowly above $41.5^{\circ}C$. Tee was lower than Tabd, and its increase was less than that of Tabd. These results suggest that changes in thermoregulatory responses are induced by an increase in abdominal temperature. Tabd increases to adjust the ratio of sensible and evaporative heat loss when Tabd is below $42.5^{\circ}C$, while the ability in body temperature regulation gradually disappears when abdominal temperature exceeds $42.5^{\circ}C$ and heat balance can not be maintained.
Lin, W.,Byrne, T.B.,Kinoshita, M.,McNeill, L.C.,Chang, C.,Lewis, J.C.,Yamamoto, Y.,Saffer, D.M.,Casey Moore, J.,Wu, H.Y.,Tsuji, T.,Yamada, Y.,Conin, M.,Saito, S.,Ito, T.,Tobin, H.J.,Kimura, G.,Kanagaw Elsevier Scientific Publishing Co 2016 Tectonophysics Vol.692 No.2
<P>To better understand the distribution of three dimensional stress states in the Nankai subduction zone, southwest Japan, we review various stress-related investigations carried out in the first and second stage expeditions of the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) by the Integrated Ocean Drilling Program (IODP) and compile the stress data. Overall, the maximum principal stress sigma(l) in the shallower levels (<similar to 1 km) is vertical from near the center of forearc basin to near the trench and; the maximum horizontal stress S-Hmax (interpreted to be the intermediate principal stress sigma(2)) is generally parallel to the plate convergence vector. The exception to this generalization occurs along the shelf edge of the Nankai margin where S-Hmax, is along strike rather than parallel to the plate convergence vector. Reorientation of the principal stresses at deeper levels (e.g., >similar to 1 km below seafloor or in underlying accretionary prism) with sigma(1) becoming horizontal is also suggested at all deeper drilling sites. We also make a comparison of the stress state in the hanging wall of the frontal plate-interface between Site C0066 in the Nankai and Site C0019 in the Japan Trench subduction zone drilled after the 2011 Mw 9.0 Tohoku-Oki earthquake. In the Japan Trench, a comparison between stress state before and after the 2011 mega-earthquake shows that the stress changed from compression before the earthquake to extension after the earthquake. As a result of the comparison between the Nankai Trough and Japan Trench, a similar current stress state with trench parallel extension was recognized at both C0006 and C0019 sites. Hypothetically, this may indicate that in Nankai Trough it is still in an early stage of the interseismic cycle of a great earthquake which occurs on the decollement and propagates to the toe (around site C0006). (C) 2015 Elsevier B.V. All rights reserved.</P>
Development of the heavy-fermion state inCe2IrIn8and the effects of Ce dilution in(Ce1−xLax)2IrIn8
Ohishi, K.,Heffner, R. H.,Ito, T. U.,Higemoto, W.,Morris, G. D.,Hur, N.,Bauer, E. D.,Sarrao, J. L.,Thompson, J. D.,MacLaughlin, D. E.,Shu, L. American Physical Society 2009 Physical review. B, Condensed matter and materials Vol.80 No.12