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RISS 인기검색어
- 검색키워드
- 저자 : Vijayan P andSuresh B (검색결과 1 건)
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Cytotoxic and antioxidant properties of four plants belonging to the genus Solanum
Santoshkumar H Dongre,Shrishailappa Badami,Ashok Godavarthi, Mahendran S,Vijayan P andSuresh B 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.1
The aim of the study was to evaluate in vitro antioxidant and cytotoxic activities of the methanolic extracts of leaves of Solanum sisymbrifolium, Solanum anguivi multiflora, Solanum barbisetum and Solanum jasminoides. In the in vitro antioxidant screening using ABTS [2,2’-azino-bis (3-ethylbenzo-thiazoline-6- sulphonic acid) diammonium salt] method, the methanol extracts of Solanum jasminoides, Solanum barbisetum and Solanum anguivi multiflora exhibited potent antioxidant activity with IC50 values 31.25 ± 0.35, 40.33 ± 0.57 and 54.33 ± 0.57 μg/ml, respectively. Solanum barbisetum also showed potent activity in DPPH [1,1-diphenyl-2-picryl hydrazyl] method with an IC50 value of 55.33 ± 1.66 μg/ml. In the cytotoxicity studies, the methanol extract of Solanum barbisetum exhibited moderate activity against Vero, HEp-2, HeLa and A-549 cell lines with IC50 values in the range of 83.30 - 127.30 μg/ml. Solanum anguivi multiflora extract also showed moderate activity against Hep-2 cell line with IC50 value of 80.13 μg/ml. Solanum barbisetum possessing both the activities requires further investigation. The aim of the study was to evaluate in vitro antioxidant and cytotoxic activities of the methanolic extracts of leaves of Solanum sisymbrifolium, Solanum anguivi multiflora, Solanum barbisetum and Solanum jasminoides. In the in vitro antioxidant screening using ABTS [2,2’-azino-bis (3-ethylbenzo-thiazoline-6- sulphonic acid) diammonium salt] method, the methanol extracts of Solanum jasminoides, Solanum barbisetum and Solanum anguivi multiflora exhibited potent antioxidant activity with IC50 values 31.25 ± 0.35, 40.33 ± 0.57 and 54.33 ± 0.57 μg/ml, respectively. Solanum barbisetum also showed potent activity in DPPH [1,1-diphenyl-2-picryl hydrazyl] method with an IC50 value of 55.33 ± 1.66 μg/ml. In the cytotoxicity studies, the methanol extract of Solanum barbisetum exhibited moderate activity against Vero, HEp-2, HeLa and A-549 cell lines with IC50 values in the range of 83.30 - 127.30 μg/ml. Solanum anguivi multiflora extract also showed moderate activity against Hep-2 cell line with IC50 value of 80.13 μg/ml. Solanum barbisetum possessing both the activities requires further investigation.
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