Nutrition and Age-Related Diseases

Vellas, Bruno 江原大學校 附設 韓國營養科學硏究所 1995 營養科學論叢 Vol.1 No.-

Challenges and Innovative Strategies in Implementing 3R in Urban Cities

( Vella Atienza ) 한국폐기물자원순환학회 2011 ISWA Vol.2011 No.0

영양과 노인병

Vellas, Bruno 江原大學校 附設 韓國營養科學硏究所 1995 營養科學論叢 Vol.1 No.-

Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer

Marco Vella,Daniela Coniglio,Alberto Abrate,Cristina Scalici Gesolfo,Elena Lo Presti,Serena Meraviglia,Vincenzo Serretta,Alchiede Simonato 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.2

Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa.

Sphenoid sinus foreign body following airbag deployment in the United States: a case report

Olson Birk J.,Vella Joseph B.,McCormick Justin P. 대한외상학회 2023 大韓外傷學會誌 Vol.36 No.2

We report a unique case of penetrating foreign bodies following a motor vehicle accident with airbag deployment. The patient presented with evidence of facial trauma and was found to have three retained foreign bodies on imaging. Notably, one foreign body was within the sphenoid sinus. This foreign body was removed uneventfully through endoscopic sinus surgery. The patient was doing well at follow-up visits. We concluded that the foreign bodies were steering wheel accessories, which detached upon airbag deployment and penetrated the patient’s face. This case report is intended to inform the public regarding the dangers of placing accessories on a steering wheel.

탄성이 있는 두 판 사이의 액체 유동에 관한 연구

김정철(JungChul Kim),Dominic Vella,김호영(Ho-Young Kim) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11

The Sequoia tree, the tallest tree in the world, grows to approximately 100 m high, implying that water should ascend to the top. Although the capillary rise though rigid tube or between rigid sheets was studied for centuries, the understanding of the dynamics of the capillary rise between flexible sheets is still far from complete. Thus we have studied experimentally and theoretically how the liquid rises between the elastically deformable sheets. We performed experiments with glass sheets as flexible sheets and silicone oil as a liquid. We construct a theoretical model that can model the liquid flow and the solid deformation resulting from the negative pressure in the gap that is originated by capillary effects. We give the results of 4 different regimes of rising phenomena, one from rigid sheet cases and three from flexible sheet cases, namely non-touching, touching and sticking types. Throughout the entire regimes, we find good agreement between the theory and the experiment.

Associations between Weight-Adjusted Waist Index and Abdominal Fat and Muscle Mass: Multi-Ethnic Study of Atherosclerosis

김지윤,최지민,Chantal A. Vella,Michael H. Criqui,Matthew A. Allison,김남훈 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.5

Background: The weight-adjusted waist index (WWI) reflected body compositional changes with aging. This study was to investigate the association of WWI with abdominal fat and muscle mass in a diverse race/ethnic population.Methods: Computed tomography (CT) data from 1,946 participants for abdominal fat and muscle areas from the Multi-Ethnic Study of Atherosclerosis (785 Whites, 252 Asians, 406 African American, and 503 Hispanics) were used. Among them, 595 participants underwent repeated CT. The WWI was calculated as waist circumference (cm) divided by the square root of body weight (kg). The associations of WWI with abdominal fat and muscle measures were examined, and longitudinal changes in abdominal composition measures were compared.Results: In all race/ethnic groups, WWI was positively correlated with total abdominal fat area (TFA), subcutaneous fat area, and visceral fat area, but negatively correlated with total abdominal muscle area (TMA) and abdominal muscle radiodensity (<i>P</i><0.001 for all). WWI showed a linear increase with aging regardless of race and there were no significant differences in the WWI distribution between Whites, Asians, and African Americans. In longitudinal analyses, over 38.6 months of follow-up, all abdominal fat measures increased but muscle measures decreased, along with increase in WWI. The more the WWI increased, the more the TFA increased and the more the TMA decreased.Conclusion: WWI showed positive associations with abdominal fat mass and negative associations with abdominal muscle mass, which likely reflects the abdominal compositional changes with aging in a multi-ethnic population.

Computed Tomography-Derived Myosteatosis and Metabolic Disorders

Iva Miljkovic,Chantal A. Vella,Matthew Allison 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.4

The role of ectopic adipose tissue infiltration into skeletal muscle (i.e., myosteatosis) for metabolic disorders has received considerable and increasing attention in the last 10 years. The purpose of this review was to evaluate and summarize existing studies focusing on computed tomography (CT)-derived measures of myosteatosis and metabolic disorders. There is consistent evidence that CT-derived myosteatosis contributes to dysglycemia, insulin resistance, type 2 diabetes mellitus, and inflammation, and, to some extent, dyslipidemia, independent of general obesity, visceral fat, and other relevant risk factors, suggesting that it may serve as a tool for metabolic risk prediction. Identification of which muscles should be examined, and the standardized CT protocols to be employed, are necessary to enhance the applicability of findings from epidemiologic studies of myosteatosis. Additional and longer longitudinal studies are necessary to confirm a role of myosteatosis in the development of type 2 diabetes mellitus, and examine these associations in a variety of muscles across multiple race/ethnic populations. Given the emerging role of myosteatosis in metabolic health, well-designed intervention studies are needed to investigate relevant lifestyle and pharmaceutical approaches.

Self-assembly of repulsive interfacial particles via collective sinking

Lee, D. G.,Cicuta, P.,Vella, D. Royal Society of Chemistry 2017 SOFT MATTER Vol.13 No.1

<P>Charged colloidal particles trapped at an air-water interface are well known to form an ordered crystal, stabilized by a long ranged repulsion; the details of this repulsion remain something of a mystery, but all experiments performed to date have confirmed a dipolar-repulsion, at least at dilute concentrations. More complex arrangements are often observed, especially at higher concentration, and these seem to be incompatible with a purely repulsive potential. In addition to electrostatic repulsion, interfacial particles may also interact via deformation of the surface: so-called capillary effects. Pair-wise capillary interactions are well understood, and are known to be too small (for these colloidal particles) to overcome thermal effects. Here we show that collective effects may significantly modify the simple pair-wise interactions and become important at higher density, though we remain well below close packing throughout. In particular, we show that the interaction of many interfacial particles can cause much larger interfacial deformations than do isolated particles, and show that the energy of interaction per particle due to this 'collective sinking'' grows as the number of interacting particles grows. Though some of the parameters in our simple model are unknown, the scaling behaviour is entirely consistent with experimental data, strongly indicating that estimating interaction energy based solely on pair-wise potentials may be too simplistic for surface particle layers.</P>

In vitro Biphasic Effect of Honey Bee Venom on Basophils from Screened Healthy Blood Donors

Salvatore Chirumbolo,Giovanna Zanoni,Riccardo Ortolani,Antonio Vella 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.1

Apis mellifera L. bee venom is the most studied hymenoptera allergen, but many aspects of its action on human basophils remain unclear. Allergologists seek evidence of the effectiveness of bee venom immunotherapy as this approach is the chosen treatment for systemic allergic reactions. The effect of bee venom on human basophils in vitro has not been studied in detail for many reasons, including the paucity of basophils in peripheral blood,inter-individual basophil response variability, and the reliability and predictability of basophil activation tests. We conducted a brief preliminary survey of the effect of Apis bee venom on healthy asymptomatic (non-allergic) subjects. A dose of an aqueous commercial extract of Apis bee venom as high as 10 μg/mL activated resting basophils (CD63=+80-90%, CD203c=+30%), while it inhibited the expression of CD63 (-50%) following basophil stimulation by the soluble agonists formyl-Met-Leu-Phe or anti-IgE. The activation of resting basophils appeared to be dose-related. Only when basophils were activated with an IgE-mediated agonist, did bee venom extract exhibit a possible priming mechanism at the lowest doses used only via CD63, while it was ineffective via CD203c. Autocrine interleukin-3 may play a role in the observed biphasic behavior.