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RISS 인기검색어
- 검색키워드
- 저자 : Veera Manohara Reddy, Y. (검색결과 5 건)
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Mallikarjuna, K.,Veera Manohara Reddy, Y.,Sravani, Bathinapatla,Madhavi, G.,Kim, Haekyoung,Agarwal, Shilpi,Gupta, Vinod Kumar Elsevier 2018 Journal of Electroanalytical Chemistry Vol.822 No.-
<P><B>Abstract</B></P> <P>Bimetallic nanomaterials have potential catalytic behaviour in hydrogenation, clean- energy production, catalysis and sensors due to their great stability, loftier activity unique electrical and chemical properties. Herein, we prepared PdAg bimetallic nanoparticles synthesized by using fungal extracted aqueous method, which is environmentally friendly cost-effective and simple procedure. The fabricated PdAg bimetallic nanoparticles were investigated by small area electron diffraction (SAED), transmission electron microscopy (TEM) X-ray photoelectron spectroscopy (XPS) and energy dispersive X-ray spectroscopy (EDX) analysis. The electrochemical response of uric acid (UA) at Pd-Ag/CPE was studied in 0.1 M phosphate buffer solution at various pH, concentration and scan rate was investigated. Compare to Bare CPE, the PdAg nanocomposite modified electrode displayed the highest electrocatalytic activity for the detection of UA A linear response in the range of 4.69–273 nM with remarkable detection limit of 5.543 nM (C<SUB>DL</SUB> = 3ϭ/M) and quantification limit of 16.64 nM (C<SUB>QL</SUB> = 10ϭ/M) was obtained. The established nanoparticles (PdAg) embedded with carbon paste electrode (Pd-Ag/CPE) makes a good analytical tool for the sensing of UA in the biological and pharmaceutical samples.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pd-Ag bimetallic nanoparticles based electrochemical sensor was fabricated </LI> <LI> uric acid is determined at nanomolar levels </LI> <LI> The practical feasibility of the developed sensor was successfully was performed </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Electrochemical investigation of uric acid at biogenic PdAg bimetallic nanostructures modified carbon paste electrode.</P> <P>[DISPLAY OMISSION]</P>
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Sada Venkateswarlu,Manthrapudi Venu,Yenegu Veera Manohara Reddy,Bathinapatla Sravani,코두루말리카주나,윤민영,G. Madhavi 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.6
A carbon paste electrode (CPE)/Cu nanowire (Cu NW)/poly(1-ethyl-3-methylimidazolium methyl sulfate) based sensor was successfully fabricated by the electro-polymerization of 1-ethyl-3-methylimidazolium methyl sulfate (EMIMS) onto the surface of Cu nanowires-modified carbon paste electrode. The morphology and chemical nature of Cu NWs were characterized by FTIR, FE-SEM, TEM, XRD techniques. The CPE/CuNWs/poly(EMIMS) showed an electrocatalytic activity toward the determination of etilefrine hydrochloride (ET-HCl) in the 0.11?M buffer solution of phosphate at pH 7.0. The CPE/CuNWs/poly(EMIMS) showed an excellent limit of detection (LOD) 2.3 ?M over the linear dynamic range of 0.1 to 1.3 ?M. The prepared CPE/CuNWs/poly(EMIMS) has exhibited high stability, good sensitivity, and low detection limit for the determination of ET-HCl. The validity of this advanced method was checked by applying in the blood plasma samples, with satisfactory results. This novel CPE/CuNWs/poly(EMIMS) can be an attractive material for the applications in biomedical and sensor fields.
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Electrochemical Detection of Influenza H5N1 Virus Antigen Based on Biomimetic Affinity Peptide
Ji Hong KIM,Chae Hwan CHO,Jae Hwan SHIN,Yenugu Veera MANOHARA REDDY,Tae Jung PARK,Jong Pil PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
The sensitive and accurate detection method which could recognize infectious diseases (e.g. influenza and Coronavirus) have attracted much attention due to their wide-spread pandemics. In this study, we developed a peptide-based electrochemical sensor that can detect influenza A H5N1 virus (H5N1) antigen, hemagglutinin (HA). High affinity peptide-displayed phage (GHPHYNNPSLQL) which had a specific binding ability to H5N1 HA was successfully identified by phage display and evaluated using enzyme-linked immunosorbent assays (ELISAs). Based on molecular structure studies, newly six peptides (IFA BP1 ~ IFA BP6) were designed and chemically synthesized to develop an electrochemical peptide sensor. The binding interactions of each peptide for H5N1 HA were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM), square wave voltammetry (SWV), isothermal titration calorimetry (ITC), and surface plasmon resonance spectroscopy (SPR). From these observations, we selected the IFA BP1 peptide as a potential molecular receptor and validated that the binding constant (Kd) and the limit of detection (LOD) were found to be 146.6 ± 42.7 nM and 3.26 nM, respectively. Furthermore, our developed electrochemical biosensor could detect HA protein spiked in human plasma compared to those determined using a commercial ELISA. Thus, the results suggested that developed sensor system could be applied for simple and rapid detection of influenza A H5N1 virus antigen.
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Ravi Kant,Keshav Kumar Saini,Ravindra Kumar Upadhyay,Yogender Singh,Y. Veera Manohara Reddy,Shishu Pal Singh,M. Abdul Kareem,K. R. Dasegowda,H. Prabhavati,Rakesh Kumar,박종필,Lalita S. Kumar 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.5
To explore novel and potent compounds with anticancer activity, two series of 1H-1,2,3-triazole tethered dibenzosuberane conjugates (5a-i and 5j-n) were synthesized using a linear and convergent approach. The synthesized novel compounds were screened for their in vitro antiproliferative activity against HepG2 cell lines using the MTT assay to explore their binding interactions with the 5EQG protein. IC50 values revealed that the most active combination against HepG2 cell lines was triazole tethered with an ortho chloro-substituted aryl ring (5g) (IC50: 99.64 μg/mL). The other compounds in the series exhibited comparable cytotoxic activities against HepG2 cell lines. The results were substantiated by molecular docking studies. The majority of the compounds demonstrated high binding affinity for the active site of the targeted protein. In addition, in silico drug-likeness prediction by the ADMET method has been explored with these compounds. All synthesized novel derivatives were characterized by mass spectrometry, infrared spectroscopy, 1H-nuclear magnetic resonance (NMR) spectroscopy, and 13C-NMR spectroscopy.
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Effect of Sulfamerazine on Structural Characteristics of Sodium Alginate Biopolymeric Films
Yerramathi Babu Bhagath,이소연,Manjula Kola,TATA SANJAY KANNA SHARMA,Annem Muniraj Beulah,Y. Veera Manohara Reddy,박태정,박종필,Ravi Sahukari,G. Madhavi 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.4
The present study was intended to describe and understand the mechanical, structural, morphological, and antimicrobial properties of sodium alginate (SA) biopolymeric films doped with sulfamerazine (SMR). Tensile strength (TS), elongation at break (E%), intermolecular interactions, crystallinity, structural integrity, and surface properties were investigated for SMR concentrations of 0.6, 1.2, and 1.8 mg/mL in the film-forming solution. The TS and E% of the various experimental films differed significantly according to the SMR concentration (p < 0.05). However, a slight reduction was observed at the highest SMR concentration (1.8 mg/mL). Fourier transform infrared spectroscopy and X-ray diffraction patterns revealed the reaction of the functional groups and conformational changes caused by the SMR and Ca2+ ions in the film matrix. Scanning electron microscopy and atomic force microscopy image analysis illustrated the cross-sectional microstructure and surface roughness of the experimental films. Overall, the doping of SMR into the SA polymer matrix was proven to have a significant effect on the morphological, structural, and mechanical properties of the resulting films.
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