Hypoglycemic, antistress, anxiolytic, and nootropic activity of roots of Rubia cordifolia Linn

Kasture, Veena S.,Kasture, Sanjay B. Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.4

The alcoholic extract of dried roots of Rubia cordifolia dose dependently reduced blood sugar level in alloxan treated rats. The extract also reduced ulcer index, plasma corticosterone in cold restrain stressed rats in dose related manner. The mice treated with alcoholic extract of Rubia cordifolia spent more time in the open arm of the elevated plus maze indicating anxiolytic activity. The extract also antagonized the amnesic effect of scopolamine in mice as indicated by reduced transfer latency in the elevated plus maze. Thus the plant bears potential for use in diabetes, stress, anxiety, and dementia.

Bacopa monniera

Kasture, Veena S,Kasture, Sanjay B Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.4

The plant is used in India as well as several countries since several centuries for treating different types of ailments. The plant is an important constituent of the Ayurvedic Materia Medica and finds mention in several ancient texts including Caraka Sanhita ($6^{th}$ century A.D.) and the Bhavprakasa ($16^{th}$ century A.D.). The scientific studies on this plant have reported several activities of this plant. Though the plant has cardiotonic, vasoconstrictor, sedative, neuro-muscular blocking, and anticancer activities, it is more popular as memory enhancer. Traditionally, a poultice made of the boiled plant is placed on the chest in acute bronchitis and coughs of children. The plant contains saponins: bacosides A and B, hersaponin, sapogenins: bacogenin $A_{1}$, $A_{2}$, and $A_{3}$ stigmasterol, and flavonoids: luteolin and luteolin-7 glucoside, nicotine, brahmine, and herpestine. This review focuses on the scientific data published since 1931.

Rubia cordifolia: a review

Rupali Patil,Mahalaxmi Mohan,Veena Kasture,Sanjay Kasture 경희대학교 융합한의과학연구소 2009 Oriental Pharmacy and Experimental Medicine Vol.9 No.1

Medicinal herbs are significant source of synthetic and herbal drugs. In the commercial market, medicinal herbs are used as raw drugs, extracts or tinctures. Isolated active constituents are used for applied research. For the last few decades, phytochemistry (study of plants) has been making rapid progress and herbal products are becoming popular. According to Ayurveda, the ancient healing system of India, the classical texts of Ayurveda, Charaka Samhita and Sushruta Samhita were written around 1000 B.C. The Ayurvedic Materia Medica includes 600 medicinal plants along with therapeutics. Herbs like turmeric, fenugreek, ginger, garlic and holy basil are integral part of Ayurvedic formulations. The formulations incorporate single herb or more than two herbs (poly-herbal formulations). Medicinal herb contains multitude of chemical compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene, lactones and oils (essential and fixed). Today there is growing interest in chemical composition of plant based medicines. Several bioactive constituents have been isolated and studied for pharmacological activity. R. cordifolia is an important medicinal plant commonly used in the traditional and Ayurvedic system of medicine for treatment of different ailments. This review illustrates its major constituents, pharmacological actions substantiating the claims made about this plant in the traditional system of medicine and its clinical applications. Medicinal herbs are significant source of synthetic and herbal drugs. In the commercial market, medicinal herbs are used as raw drugs, extracts or tinctures. Isolated active constituents are used for applied research. For the last few decades, phytochemistry (study of plants) has been making rapid progress and herbal products are becoming popular. According to Ayurveda, the ancient healing system of India, the classical texts of Ayurveda, Charaka Samhita and Sushruta Samhita were written around 1000 B.C. The Ayurvedic Materia Medica includes 600 medicinal plants along with therapeutics. Herbs like turmeric, fenugreek, ginger, garlic and holy basil are integral part of Ayurvedic formulations. The formulations incorporate single herb or more than two herbs (poly-herbal formulations). Medicinal herb contains multitude of chemical compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene, lactones and oils (essential and fixed). Today there is growing interest in chemical composition of plant based medicines. Several bioactive constituents have been isolated and studied for pharmacological activity. R. cordifolia is an important medicinal plant commonly used in the traditional and Ayurvedic system of medicine for treatment of different ailments. This review illustrates its major constituents, pharmacological actions substantiating the claims made about this plant in the traditional system of medicine and its clinical applications.

Protective potential of Coriandrum sativum seed extract on E. coli induced peritonitis and bacteraemia in mice

Neha Jain,Jaya Dwivedi,Veena S. Kasture,Swapnil Sharma 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4

Peritonitis is an inflammatory condition of peritoneal cavity. Escherichia coli is one of the causative microorganism reported to be involved in the several etiologies associated with peritoneal infection. Many antimicrobial agents are available; however, increased incidence of microbial resistance is an important concern for medical practitioner. Medicinal plants were used since ancient time for treatment of many infectious diseases, but still the potential of these plant resources is not well explored. Present study was designed to investigate protective potential of Coriandrum sativum seed extract on E. coli induced peritonitis and bacteraemia, when used alone or in combination with Levofloxacin. Different extracts were prepared by successive solvent extraction utilizing solvents of variable polarity viz. petroleum ether, ethyl acetate, chloroform and methanol (70%). These extracts were assessed for antimicrobial potential utilizing in-vitro well diffusion assay and MIC determination with E. coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus cereus. Being most potent among other extracts in in-vitro assays, methanolic extract was tested in an invivo model of E. coli induced peritonitis with immune-compromised mice at the dose of 400 mg/kg/day alone and in combination with Levofloxacin (20 mg/kg). Methanolic extract of Coriandrum sativum seeds exhibited potent protective potential against E. coli induced peritonitis and bacteraemia.

Rubia cordifolia: a review

Patil, Rupali,Mohan, Mahalaxmi,Kasture, Veena,Kasture, Sanjay Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.1

Medicinal herbs are significant source of synthetic and herbal drugs. In the commercial market, medicinal herbs are used as raw drugs, extracts or tinctures. Isolated active constituents are used for applied research. For the last few decades, phytochemistry (study of plants) has been making rapid progress and herbal products are becoming popular. According to Ayurveda, the ancient healing system of India, the classical texts of Ayurveda, Charaka Samhita and Sushruta Samhita were written around 1000 B.C. The Ayurvedic Materia Medica includes 600 medicinal plants along with therapeutics. Herbs like turmeric, fenugreek, ginger, garlic and holy basil are integral part of Ayurvedic formulations. The formulations incorporate single herb or more than two herbs (poly-herbal formulations). Medicinal herb contains multitude of chemical compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene, lactones and oils (essential and fixed). Today there is growing interest in chemical composition of plant based medicines. Several bioactive constituents have been isolated and studied for pharmacological activity. R. cordifolia is an important medicinal plant commonly used in the traditional and Ayurvedic system of medicine for treatment of different ailments. This review illustrates its major constituents, pharmacological actions substantiating the claims made about this plant in the traditional system of medicine and its clinical applications.