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Neha Jain,Jaya Dwivedi,Veena S. Kasture,Swapnil Sharma 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4
Peritonitis is an inflammatory condition of peritoneal cavity. Escherichia coli is one of the causative microorganism reported to be involved in the several etiologies associated with peritoneal infection. Many antimicrobial agents are available; however, increased incidence of microbial resistance is an important concern for medical practitioner. Medicinal plants were used since ancient time for treatment of many infectious diseases, but still the potential of these plant resources is not well explored. Present study was designed to investigate protective potential of Coriandrum sativum seed extract on E. coli induced peritonitis and bacteraemia, when used alone or in combination with Levofloxacin. Different extracts were prepared by successive solvent extraction utilizing solvents of variable polarity viz. petroleum ether, ethyl acetate, chloroform and methanol (70%). These extracts were assessed for antimicrobial potential utilizing in-vitro well diffusion assay and MIC determination with E. coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus cereus. Being most potent among other extracts in in-vitro assays, methanolic extract was tested in an invivo model of E. coli induced peritonitis with immune-compromised mice at the dose of 400 mg/kg/day alone and in combination with Levofloxacin (20 mg/kg). Methanolic extract of Coriandrum sativum seeds exhibited potent protective potential against E. coli induced peritonitis and bacteraemia.
Agrawal, Meenakshi,Jain, Sonika,Agarwal, Anshu,Dwivedi, Jaya,Sharma, Swapnil,Kishore, D. 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.2
Exceedingly facile protocols based on the reactivity of corresponding oxoketenedithioacetal (4), 2-(dimethylaminomethylene) ketone (5), ${\beta}$-oxoenolether (6) and ${\alpha}$, ${\beta}$-unsaturated ketone (7) resulted from 7-ethyl-3,4 dihydroazepino[3,2-b] carbazole-2,5 (1H,7H)-dione (3) on its reaction with base catalyzed condensation of (a) $CS_2+$ MeI (b) DMF-DMA (c) H-COOEt and (IV) $C_6H_5CHO$ respectively, has been explored to provide an easy access of their isoxazole and pyrazole annulated analogues (8-13) of medicinal interest. The key compound 3 from which, the synthesis proceeded was in turn realized on the reaction of commercial 3-amino-9-ethyl carbazole (1) with ethyl succinyl chloride, under the conditions of Friedel-Crafts acylation followed by cyclocondensation of the resulting intermediate 2 with PPA. Isoxazolo and pyrazolo annulated analogues of carbazolo condensed azepinone derivatives (8-13) were screened for their in-vitro antimicrobial potential against various bacterial and fungal species. Besides this pyrazole derivative (8) was also evaluated for its CNS depressant potential in mice using photoactometer.
Traditional uses, phytochemistry and pharmacology of Bauhinia racemosa Lam - a review
Vishal Soni,Arvind Kumar Jha,Jaya Dwivedi,Priyanka Soni 셀메드 세포교정의약학회 2015 TANG Vol.5 No.4
Bahunia racemosa family, Caesalpiniaceae, is one of the precious resources of the earth. It has played a significant role in human civilization since ancient times. It is tall sized tree growing throughout India, Ceylon, China, and Timor. The different part of this plant contains β-sitosterol and β-amyrin, flavonols (kaempferol and quercetin) and two coumarins (scopoletin and scopolin), tannins etc. Various part of this plant has great pharmacological potential with a great utility and usage as folklore medicine as analgesic, antipyretic, anti-inflammatory, antispasmodic and antimicrobial activity. This review mainly focus on the exclusive review work on the traditional, phytochemical and pharmacological activities of this plant.
Traditional uses, phytochemistry and pharmacological profile of Bambusa arudinacea Retz
Vishal Soni,Arvind Kumar Jha,Jaya Dwivedi,Priyanka Soni 셀메드 세포교정의약학회 2013 셀메드 (CellMed) Vol.3 No.3
Bambusa arundinacea family Graminae, is one of the precious plant resources of the earth. It has played a significant role in human civilization since ancient times. It is tall sized tree growing throughout India, moist parts of India. It also occurs in Sri Lanka, Malaya, Peru and Myanmar. The different parts of this plant contain silica, cholin, betain, cynogenetic glycosides, albuminoids, oxalic acid, reducing sugar, resins, waxes, benzoic acid, arginine, cysteine, histidine, niacin, riboflavin, thiamine, protein, gluteline, contains lysine, methionine, betain, cholin, proteolytic enzyme, nuclease, urease. Various parts of this plant such as leaf, root, shoot and seed possess anti-inflammatory, antiulcer, anti-diabetic, anti-oxidant, anthelmintic, antifertility, antibacterial, insectisidal, antiarthritic, vessele protection etc. This review mainly focuses on the traditional, phytochemical and pharmacological information of Bambusa arundinacea.