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- 저자 : Vasylyeva, Vera (검색결과 2 건)
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Rö,nsberg, David,Debbab, Abdessamad,Má,ndi, Attila,Vasylyeva, Vera,Bö,hler, Philip,Stork, Bjö,rn,Engelke, Laura,Hamacher, Alexandra,Sawadogo, Richard,Diederich, Marc,Wray, Vict American Chemical Society 2013 Journal of organic chemistry Vol.78 No.24
<P>Four tetrahydroxanthone dimers (<B>1</B>–<B>4</B>) and four biogenetically related monomers (<B>5</B>–<B>8</B>), including the new derivatives <B>4</B>–<B>6</B>, were isolated from the endophyte Phomopsis longicolla. The absolute configurations of <B>2</B>–<B>4</B> were established for the first time by TDDFT electronic circular dichroism calculations, and that of phomoxanthone A (<B>1</B>) was revised by X-ray crystallography. Phomoxanthone A (<B>1</B>) showed the strongest pro-apoptotic activity when tested against a panel of human cancer cell lines, including cisplatin-resistant cells, whereas it was up to 100-fold less active against healthy blood cells. It was also the most potent activator of murine T lymphocytes, NK cells, and macrophages, suggesting an activation of the immune system in parallel to its pro-apoptotic activity. This dual effect in combating cancer cells could help in fighting resistance during chemotherapy. Preliminary structure–activity studies of isolated compounds and derivatives obtained by semisynthesis (<B>9a</B>–<B>11</B>) hinted at the location of the biaryl axis and the presence of acetyl groups as important structural elements for the biological activity of the studied tetrahydroxanthones.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2013/joceah.2013.78.issue-24/jo402066b/production/images/medium/jo-2013-02066b_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jo402066b'>ACS Electronic Supporting Info</A></P>
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Hypertension secondary to renal hypoplasia presenting as acute heart failure in a newborn
Jena Deitrick,Kayle Stevenson,Daniel Nguyen,William Sessions,Vijay Linga,Tetyana Vasylyeva 대한고혈압학회 2019 Clinical Hypertension Vol.25 No.3
Introduction: Neonatal hypertension is defined as persistent systolic and/or diastolic blood pressures above the 95th percentile compared to other infants of similar gestational age and size. Neonatal hypertension is a rare condition, occurring in only 0.2–3.0% of neonates. The most common etiology of neonatal hypertension is renal vascular or parenchymal disease, and it is usually detected on routine examination in an asymptomatic child. However, it may present in a variety of manners, including acute heart failure, renal dysfunction, feeding difficulties, failure to thrive, tachypnea, apnea, lethargy, irritability, or seizures. Case presentation: A term female was born via repeat caesarean section with vacuum extraction. On day of life (DOL) 3, the baby presented to the emergency department with poor feeding and lethargy. Initial laboratory tests indicated severe metabolic acidosis and the patient was transferred to our neonatal intensive care unit (NICU). During the hospital stay, the patient had intermittently high blood pressures. An echocardiogram was ordered, which demonstrated a severely decreased ejection fraction of 33%, but no signs of coarctation of the aorta. The low ejection fraction and constellation of symptoms were consistent with the diagnosis of acute heart failure, so treatment with milrinone was initiated. Further labs demonstrated elevated renin and aldosterone, and a computed tomography scan showed right kidney hypoplasia with reduced perfusion. This suggested a renovascular etiology of hypertension causing the initial presentation of acute heart failure. The patient was started on enalapril and clonidine for blood pressure control and was discharged with a home blood pressure monitoring system. At 5 months of life, this patient was still on enalapril and amlodipine as well as home blood pressure monitoring. Conclusions: Acute heart failure is a rare presentation of neonatal hypertension, and prompt recognition and treatment for the underlying systemic hypertension is necessary to provide the best possible outcomes for patients. Due to the lack of sufficient evidence, treatment of hypertension in newborns is often anecdotal in nature. Further awareness of neonatal hypertension and research determining ideal methods of diagnosis and treatment would benefit physicians and their affected patients.
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