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Mutational Data Loading Routines for Human Genome Databases: the BRCA1 Case
Van Der Kroon, Matthijs,Ramirez, Ignacio Lereu,Levin, Ana M.,Pastor, Oscar,Brinkkemper, Sjaak Korean Institute of Information Scientists and Eng 2010 Journal of Computing Science and Engineering Vol.4 No.4
The last decades a large amount of research has been done in the genomics domain which has and is generating terabytes, if not exabytes, of information stored globally in a very fragmented way. Different databases use different ways of storing the same data, resulting in undesired redundancy and restrained information transfer. Adding to this, keeping the existing databases consistent and data integrity maintained is mainly left to human intervention which in turn is very costly, both in time and money as well as error prone. Identifying a fixed conceptual dictionary in the form of a conceptual model thus seems crucial. This paper presents an effort to integrate the mutational data from the established genomic data source HGMD into a conceptual model driven database HGDB, thereby providing useful lessons to improve the already existing conceptual model of the human genome.
Mutational Data Loading Routines for Human Genome Databases : the BRCA1 Case
Matthijs van der Kroon,Ignacio Lereu Ramirez,Ana M. Levin,Oscar Pastor,Sjaak Brinkkemper 한국정보과학회 2010 Journal of Computing Science and Engineering Vol.4 No.4
The last decades a large amount of research has been done in the genomics domain which has and is generating terabytes, if not exabytes, of information stored globally in a very fragmented way. Different databases use different ways of storing the same data, resulting in undesired redundancy and restrained information transfer. Adding to this, keeping the existing databases consistent and data integrity maintained is mainly left to human intervention which in turn is very costly, both in time and money as well as error prone. Identifying a fixed conceptual dictionary in the form of a conceptual model thus seems crucial. This paper presents an effort to integrate the mutational data from the established genomic data source HGMD into a conceptual model driven database HGDB, thereby providing useful lessons to improve the already existing conceptual model of the human genome.