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Kim, Inkyoung,Unny-Law, Rohan Korea Consensus Institute(KCI) 2019 Analyses & alternatives Vol.3 No.2
How can we reconcile our aspirations for more economic growth or prosperity with the constraints of a finite planet? One of the high-income countries, Japan, makes us wonder if we can deal with two different challenges simultaneously: overcoming economic recession and solving environmental degradation. This study investigates the supply-side perspective which highlights the productive capacity and efficiency of the economy through economic lenses and the demand-side perspective which highlights the Japanese personal lifestyles through social lenses. This study aims to answer the question, if Japan's sustainable consumption behavior is counter to economic development whilst environmentally proactive. It finds that translating individual practices and cultures of sustainability into the macro- scopic economic growth path is key to a sustainable and healthy Japan.
Adikesavan, Anbu Karani,Unni, Emmanual,Jaiswal, Anil K. Elsevier 2018 Biochemical and biophysical research communication Vol.501 No.3
<P>This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).</P><P>The University of Maryland, Baltimore conducted an internal investigation which found that the article was compromised and a preponderance of evidence supports retraction of the publication in order to correct the scientific record and ensure its integrity.</P><P>The Editor-in-Chief has decided to retract this article. This article has been found to contain manipulated and enhanced figures, namely figures 1D and 1E, 4A and 4B.</P>
Inkyoung Kim,Rohan Unny-Law 사단법인 코리아컨센서스연구원 2019 분석과 대안 Vol.3 No.2
How can we reconcile our aspirations for more economic growth or prosperity with the constraints of a finite planet? One of the high-income countries, Japan, makes us wonder if we can deal with two different challenges simultaneously: overcoming economic recession and solving environmental degradation. This study investigates the supply-side perspective which highlights the productive capacity and efficiency of the economy through economic lenses and the demand-side perspective which highlights the Japanese personal lifestyles through social lenses. This study aims to answer the question, if Japan’s sustainable consumption behavior is counter to economic development whilst environmentally proactive. It finds that translating individual practices and cultures of sustainability into the macro- scopic economic growth path is key to a sustainable and healthy Japan.
Tapan Dey,Prachurjya Dutta,Prasenjit Manna,Jatin Kalita,Hari Prasanna Deka Boruah,Alak Kumar Buragohain,Balagopalan Unni 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.4
Vasicinone, a quinazoline alkaloid from Adhatoda vasica Nees. is well known for its bronchodilator activity. However its antiproliferative activities is yet to be elucidated. Here-in we investigated the anti-proliferative effect of vasicinone and its underlying mechanism against A549 lung carcinoma cells. The A549 cells upon treatment with various doses of vasicinone (10, 30, 50, 70 μM) for 72 h showed significant decrease in cell viability. Vasicinone treatment also showed DNA fragmentation, LDH leakage, and disruption of mitochondrial potential, and lower wound healing ability in A549 cells. The Annexin V/PI staining showed disrupted plasma membrane integrity and permeability of PI in treated cells. Moreover vasicinone treatment also lead to down regulation of Bcl-2, Fas death receptor and up regulation of PARP, BAD and cytochrome c, suggesting the anti-proliferative nature of vasicinone which mediated apoptosis through both Fas death receptors as well as Bcl-2 regulated signaling. Furthermore, our preliminary studies with vasicinone treatment also showed to lower the ROS levels in A549 cells and have potential free radical scavenging (DPPH, Hydroxyl) activity and ferric reducing power in cell free systems. Thus combining all, vasicinone may be used to develop a new therapeutic agent against oxidative stress induced lung cancer.
Dey, Tapan,Dutta, Prachurjya,Manna, Prasenjit,Kalita, Jatin,Boruah, Hari Prasanna Deka,Buragohain, Alak Kumar,Unni, Balagopalan The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.4
Vasicinone, a quinazoline alkaloid from Adhatoda vasica Nees. is well known for its bronchodilator activity. However its anti-proliferative activities is yet to be elucidated. Here-in we investigated the anti-proliferative effect of vasicinone and its underlying mechanism against A549 lung carcinoma cells. The A549 cells upon treatment with various doses of vasicinone (10, 30, 50, $70{\mu}M$) for 72 h showed significant decrease in cell viability. Vasicinone treatment also showed DNA fragmentation, LDH leakage, and disruption of mitochondrial potential, and lower wound healing ability in A549 cells. The Annexin V/PI staining showed disrupted plasma membrane integrity and permeability of PI in treated cells. Moreover vasicinone treatment also lead to down regulation of Bcl-2, Fas death receptor and up regulation of PARP, BAD and cytochrome c, suggesting the anti-proliferative nature of vasicinone which mediated apoptosis through both Fas death receptors as well as Bcl-2 regulated signaling. Furthermore, our preliminary studies with vasicinone treatment also showed to lower the ROS levels in A549 cells and have potential free radical scavenging (DPPH, Hydroxyl) activity and ferric reducing power in cell free systems. Thus combining all, vasicinone may be used to develop a new therapeutic agent against oxidative stress induced lung cancer.