http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Ugai, Hiroyuki (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
-
Tsuda, Yasuhiro,Ugai, Hiroyuki,Wunderlich, Glen,Shin, Jae-Gook Elsevier 2019 Clinical therapeutics Vol.41 No.5
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>This study's primary goal was to evaluate the safety profile, tolerability, pharmacokinetics, and dose proportionality of BI 425809, a potent and selective inhibitor of glycine transporter 1, in healthy Chinese and Japanese subjects.</P> <P><B>Methods</B></P> <P>This single center, double-blind, single-rising dose study conducted in Korea randomly assigned (3:1) subjects within each ethnic subgroup (Chinese and Japanese) to receive a single dose of BI 425809 (10, 25, or 50 mg) or placebo. The primary end point was number (%) of subjects with drug-related adverse events (AEs). Secondary end points included AUC, C<SUB>max</SUB>, t<SUB>max</SUB>, and t<SUB>½</SUB> for BI 425809 in plasma. The CL/F and volume of distribution (V<SUB>z</SUB>/F) were also measured.</P> <P><B>Findings</B></P> <P>Of the 49 subjects enrolled into the study (24 Chinese, 25 Japanese), 36 were randomly assigned to receive BI 425809 (12 per dose group) and 13 to receive placebo. All subjects were analyzed for the primary end point and completed the study. Overall, 4 of 49 subjects (8.2%) reported ≥1 AE (placebo: n = 1, BI 425809: n = 3). One drug-related AE of moderate somnolence was reported by a Japanese subject who received placebo. In both subgroups, slightly lower than dose-proportional increases in exposure (AUC and C<SUB>max</SUB>) were observed with increasing dose. In addition, median t<SUB>max</SUB> was 3.5–4.0 h, with a geometric mean t<SUB>½</SUB> of 29.0–41.2 h. CL/F was similar between Chinese and Japanese subjects and increased with increasing dose (10–50 mg: 68.1–111 mL/min). V<SUB>z</SUB>/F was 209–315 L and similar between the subgroups.</P> <P><B>Implications</B></P> <P>BI 425809 was generally well tolerated in healthy Chinese and Japanese subjects with no significant findings for tolerability. No apparent difference in the pharmacokinetic variables of BI 425809 was observed between Chinese and Japanese subjects. The safety profile results and pharmacokinetic exposure levels are consistent with previous trials in Caucasian subjects. ClinicalTrials.gov identifier: NCT02383888.</P>
-
-
Behaviors of Pile Croup Installed Near Inclined Ground
Chae, Kwang-Seok,Ugai, Keizo,Yoon, Gil-Lim Korean Geotechnical Society 2003 지반 : 한국지반공학회지 Vol.19 No.3
사면을 포함한 경사지에 설치된 송전탑, 교각, 고층빌딩 등을 지지하는 말뚝은 풍하중, 지진, 차량 등에 의한 수평하중을 고려하여 설계되어야 한다. 이러한 사면이나 경사지에 설치된 수평하중을 받는 말뚝은 편평한 지반에 비하여, 수평지지력이 감소하기 때문이다. 그러므로 이러한 구조물은 일반적으로 강성이 높고, 대구경의 기초인 피어기초가 사용된다. 수평하중을 받는 피어기초는 일반적으로 장대말뚝과 다른 거동을 한다. 즉, 수평하중에 의하여 말뚝 자체의 회전이 발생하고, 그 회전의 중심점 상부의 사면측의 수동토압에 의존하여 지반파괴가 발생한다는 측면에서 짧은 강성 말뚝과 유사한 거동을 한다. 본 논문은 모래사면의 언덕 근처에 설치된 짧은 말뚝의 수평하중의 영향에 대한 실험 및 수치해석 결과를 포함한다. 대부분을 모형실험과 3차원 탄소성 유한요소해석의 비교, 결과를 기술하였다. 먼저, 사면 언덕에서 모형말뚝까지의 거리를 3종류로 구분하여 단항의 모형실험과 군항말뚝의 수평하중 특성을 파악하기 위하여 수평지반과 사면지반(경사 30$^{\circ}$)에 대하여 말뚝중심간의 거리를 각2종류로 모형실험을 실시하였다. 동시에 3차원 탄소성 유한요소법에 의한 수치해석을 통하여 모형실험의 결과와의 비교를 시도하였다. 사용된 모래지반은 배수조건하에서 삼축압축실험으로 재현하였다. 3차원 탄소성 유한요소해석에서 완전탄소성모델의 파괴기준은 Mohr-Coulomb식, 소성 포텐셜은 Drucker-Prage식을 이용한 MC-DP모델을 적용하였다. 연구결과, 3차원탄소성 유한요소법이 사질토 지반에 설치된 짧은 말뚝의 수평거동을 파악하는데 유효하다는 것을 확인하였다. Many transmission towers, high-rise buildings and bridges are constructed near steep slopes and are supported by large-diameter piles. These structures may be subjected to large lateral loads, such as violent winds and earthquakes. Widely used types of foundations for these structures are pier foundations, which have large-diameters with high stiffness. The behavior of a pier foundation subjected to lateral loads is similar to that of a short rigid pile because both elements seem to fail by rotation developing passive resistance on opposite faces above and below the rotation point, unlike the behavior of a long flexible pile. This paper describes the results of several numerical studies performed with a three-dimensional finite element method (FEM) of model tests of a laterally loaded short pile located near slopes, respectively. In this paper, the results of model tests of single piles and pile groups subjected to lateral loading, in homogeneous sand with 30$^{\circ}$ slopes and horizontal ground were analyzed by the 3-D FE analyses. The pile was assumed to be linearly elastic. The sand was assumed to have non-associative characteristics, following the MC-DP model. The failure criterion is governed by the Mohr-Coulomb equation and the plastic potential is given by the Drucker-Prager equation. The main purpose of this paper is the validation of the 3-D elasto-plastic FEM by comparisons with the experimental data.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
