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( Lisa Tully ),( John Humiston ),( Alan Cash ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.2
Objective Premenstrual syndrome (PMS) affects millions of women. While over-the-counter products have helped with the physical symptoms of PMS, emotional symptoms have been less well supported. The objective of this trial was to measure the effect of an oxaloacetate/vitamin C combination on the major emotional symptoms of PMS, including depression, anxiety, perceived stress, aggression, and suicidal ideation. Methods Forty-eight women experiencing PMS completed a baseline survey comprising the Beck’s Depression Inventory, Cohen Perceived Stress Scale, Generalized Anxiety Disorder Test, and Buss-Perry Aggression Questionnaire. After baseline measurements, participants were randomly assigned to take either 2 capsules of 100 mg oxaloacetate/150 mg ascorbic acid, or 2 capsules of rice flour (placebo) for their entire menstrual cycle. At menstruation, the women completed the 4 surveys again. The women then switched capsules in a cross-over design and continued the study for an additional menstrual cycle. The final assessment was repeated at menstruation. Statistical analysis of the 4 surveys was performed to examine efficacy. Results Oxaloacetate/vitamin C supplementation during PMS significantly improved depression, perceived stress, anxiety, aggression, and suicidal ideation. The mean improvement in depression was 54.1%, 35.8% for perceived stress, 51.43% for generalized anxiety, and 17.8% for aggression. Suicidal ideation was reduced by 47.9%. All results were highly significant. Conclusion A combination of oxaloacetate and vitamin C supplementation helped to alleviate depression, anxiety, perceived stress, aggression, and suicidal ideation symptoms associated with PMS. Trial Registration Clinical Research Information Service Identifier: NCT03509714
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How Americans Feel About Asian Countries and Why
Benjamin I. Page,Julia Rabinovich,David G. Tully 동아시아연구원 2008 Journal of East Asian Studies Vol.8 No.1
Americans feelings about foreign countries are embedded in foreign policy belief systems and affect policy preferences. The analysis of nine surveys of the U.S. general public conducted between 1978 and 2006 indicates that on average Americans have had rather lukewarm or slightly cool, nearly neutral feelings toward China, India, South Korea, Taiwan and Indonesia; warm feelings toward Japan and Australia; and cold feelings toward North Korea and (at least since 2001) toward Pakistan and Afghanistan.Individuals feelings are affected by certain personal and social characteristics. High levels of formal education tend to make people feel considerably warmer toward most of these countries especially Pakistan, Afghanistan, and India. Education has part of its effect through increased information: those who know more about the world generally express warmer feelings. But most important are internationalist attitudes, especially putting a relatively low priority on U.S. domestic threats and concerns, embracing capitalism and world markets, and espousing world antipoverty goals. National security considerations play only a limited part. Policy implications are discussed.
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P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging
Haoran Wang,강호만,Jason Dinh,Shinya Yokomizo,Wesley R. Stiles,Molly Tully,Kevin Cardenas,Surbhi Srinivas,Jason Ingerick,Sung Ahn,Kai Bao,최학수 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Due to the deep tissue penetration and reduced scattering, NIR-II fluorescence imaging is advantageous over conventional visible and NIR-I fluorescence imaging for the detection of bone growth, metabolism, metastasis, and other bone-related diseases. Methods: Bone-targeted heptamethine cyanine fluorophores were synthesized by substituting the meso-carbon with a sulfur atom, resulting in a bathochromic shift and increased fluorescence intensity. The physicochemical, optical, and thermal stability of newly synthesized bone-targeted NIR fluorophores was performed in aqueous solvents. Calcium binding, bone-specific targeting, biodistribution, pharmacokinetics, and 2D and 3D NIR imaging were performed in animal models. Results: The newly synthesized S-substituted heptamethine fluorophores demonstrated a high affinity for hydroxyapatite and calcium phosphate, which improved bone-specific targeting with signal-background ratios > 3.5. Particularly, P800SO3-PEG showed minimum nonspecific uptake, and most unbound molecules were excreted into the urinary bladder. Histological analyses demonstrated that P800SO3-PEG remained stable in the bone for over two weeks and was incorporated into bone matrices. Interestingly, the flexible thiol ethylene glycol linker on P800SO3-PEG induced a promising photothermal effect upon NIR laser irradiation, demonstrating potential theranostic imaging. Conclusions: P800SO3-PEG shows a high affinity for bone tissues, deeper tissue imaging capabilities, minimum nonspecific uptake in the major organs, and photothermal effect upon laser irradiation, making it optimal for bonetargeted theranostic imaging.
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Marieke J. Krimphove,Stephen W. Reese,Xi Chen,Maya Marchese,Daniel Pucheril,Eugene Cone,Wesley Chou,Karl H. Tully,Adam S. Kibel,Richard D. Urman,Steven L. Chang,Luis A. Kluth,Prokar Dasgupta,Quoc-Dien 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.1
Purpose: Does surgical approach (minimally invasive vs. open) and type (radical vs. partial nephrectomy) affects opioid use and workplace absenteeism. Materials and Methods: Retrospective multivariable regression analysis of 2,646 opioid-naïve patients between 18 and 64 undergoing radical or partial nephrectomy via either a minimally invasive vs. open approach for kidney cancer in the United States between 2012 and 2017 drawn from the IBM Watson Health Database was performed. Outcomes included: (1) opioid use in opioid-naïve patients as measured by opioid prescriptions in the post-operative setting at early, intermediate and prolonged time periods and (2) workplace absenteeism after surgery. Results: Patients undergoing minimally invasive surgery had a lower odds of opioid use in the early and intermediate post-operative periods (early: odds ratio [OR], 0.77; 95% confidence interval [CI], 0.62–0.97; p=0.02, intermediate: OR, 0.60; 95% CI, 0.48–0.75; p<0.01), but not in the prolonged setting (prolonged: OR, 1.00; 95% CI, 0.75–1.34; p=0.98) and had earlier return to work (minimally invasive vs. open: −10.53 days; 95% CI, −17.79 to −3.26; p<0.01). Controlling for approach, patient undergoing partial nephrectomy had lower rates of opioid use across all time periods examined and returned to work earlier than patients undergoing radical nephrectomy (partial vs. radical: −14.41 days; 95% CI, −21.22 to −7.60; p<0.01). Conclusions: Patients undergoing various forms of surgery for kidney cancer had lower rates of peri-operative opioid use, fewer days of workplace absenteeism, but no difference in long-term rates of opioid use in patients undergoing minimally invasive as compared to open surgery.
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