http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Tullio Valente,Giorgio Bocchini,Maurizio Cappelli Bigazzi,Massimo Muto,Paolo Golino,Giacomo Sica 대한흉부외과학회 2020 Journal of Chest Surgery (J Chest Surg) Vol.53 No.5
Transcatheter leadless pacemaker dislodgment is a rare and potentially fatal complication of leadless device implantation. We present the first case of multidetector computed tomography images of leadless pacemaker migration and embolization in the pulmonary middle lobe artery. The patient was managed by percutaneous retrieval of the dislodged device and re-implantation in the appropriate position.
Design of a Telescopic tower for wind energy production with reduced environmental impact
Antonio Pantano,Tullio Tucciarelli,Nicola Montinaro,Antonio Mancino 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.1
A prototype of a telescopic pole for wind energy production with low environmental impact and its lifting system for a 60–250 kW turbine and a height of 30 m have been designed and manufactured. A telescopic tower, which is raised and lowered by automation or by remote control, allows to differentiate the presence of the generator within the landscape over time. The technology currently available for lifting and lowering wind turbines is made up of telescopic poles of heights of less than 10 meters and with tilting posts of height below 30 m. Without a state of the art to refer to, the telescopic pole and its lifting system have been designed starting from scratch and solving with innovative ideas the various criticalities that have arisen. The design of the telescopic coupling, the design for maintaining the preload and for the rotational decoupling, the optimization the design of the pairs of sleeves by numerical simulations, the design of the pegs and the bushes of the jack-up lifting system have been presented. The prototype was installed in Caltanissetta, Italy, and successfully tested.
Kang, Jeehoon,Park, Kyung,Palmerini, Tullio,Stone, Gregg,Lee, Michael,Colombo, Antonio,Chieffo, Alaide,Feres, Fausto,Abizaid, Alexandre,Bhatt, Deepak,Valgimigli, Marco,Hong, Myeong-Ki,Jang, Yangsoo,Gi Georg Thieme Verlag KG 2019 Thrombosis and Haemostasis Vol.119 No.1
<P> Background Prolonged dual anti-platelet therapy (DAPT) is intended to reduce ischaemic events, at the cost of an increased bleeding risk in patients undergoing percutaneous coronary intervention (PCI). In this study, we evaluated whether race influences the ischaemia/bleeding risk trade-off.</P><P> Methods We searched for randomized clinical trials (RCTs) comparing DAPT duration after PCI. To compare the benefit or harm between DAPT duration by race, individual patient-level landmark meta-analysis was performed after discontinuation of the shorter duration DAPT group in each RCT. The primary ischaemic endpoint was major adverse cardiac events (MACEs), and the primary bleeding endpoint was major bleeding events (clinicaltrials.gov NCT03338335).</P><P> Results Seven RCTs including 16,518 patients (8,605 East Asians, 7,913 non-East Asians) were pooled. MACE occurred more frequently in non-East Asians (0.8% vs. 1.8%, p < 0.001), while major bleeding events occurred more frequently in East Asians (0.6% vs. 0.3%, p = 0.001). In Cox proportional hazards model, prolonged DAPT significantly increased the risk of major bleeding in East Asians (hazard ratio [HR], 2.843, 95% confidence interval [CI], 1.474-5.152, p = 0.002), but not in non-East Asians (HR, 1.375, 95% CI, 0.523-3.616, p = 0.523). East Asians had a higher median probability risk ratio of bleeding to ischaemia (0.66 vs. 0.15), and the proportion of patients with higher probability of bleeding than ischaemia was significantly higher in East Asians (32.3% vs. 0.4%, p < 0.001).</P><P> Conclusion We suggest that the ischaemia/bleeding trade-off may be different between East Asians and non-East Asians. In East Asians, prolonged DAPT may have no effect in reducing the ischaemic risk, while significantly increases the bleeding risk.</P>
Lee, Seung-Yul,Hong, Myeong-Ki,Palmerini, Tullio,Kim, Hyo-Soo,Valgimigli, Marco,Feres, Fausto,Colombo, Antonio,Gilard, Martine,Shin, Dong-Ho,Kim, Jung-Sun,Kim, Byeong-Keuk,Ko, Young-Guk,Choi, Donghoon Elsevier 2018 JACC. Cardiovascular interventions Vol.11 No.5
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>This study sought to evaluate the optimal duration of dual antiplatelet therapy (DAPT) after the implantation of a drug-eluting stent (DES) in elderly patients.</P> <P><B>Background</B></P> <P>Qualified studies to evaluate the optimal duration of DAPT in elderly patients have been very limited.</P> <P><B>Methods</B></P> <P>Using 6 randomized trials that compared short-term (≤6 months) and long-term (12 months) DAPT, individual participant data meta-analysis was performed in elderly patients (≥65 years of age). The primary study outcome was the 12-month risk of a composite of myocardial infarction, definite or probable stent thrombosis, or stroke. The major secondary outcome was the 12-month risk of major bleeding.</P> <P><B>Results</B></P> <P>The primary outcome risk did not significantly differ between patients receiving short-term and long-term DAPT (hazard ratio [HR]: 1.12; 95% confidence interval [CI]: 0.88 to 1.43; p = 0.3581) in the overall group of study participants. In subgroup analysis, a significant interaction between age and DAPT duration was observed for primary outcome risk (p for interaction = 0.0384). In the subset of younger patients (<65 years of age, n = 6,152), short-term DAPT was associated with higher risk of primary outcome (HR: 1.67; 95% CI: 1.14 to 2.44; p = 0.0082). In elderly patients (n = 5,319), however, the risk of primary outcome did not significantly differ between patients receiving short-term and long-term DAPT (HR: 0.84; 95% CI: 0.60 to 1.16; p = 0.2856). Short-term DAPT was associated with a significant reduction in major bleeding compared with long-term DAPT (HR: 0.50; 95% CI: 0.30 to 0.84; p = 0.0081) in the overall group, and particularly in elderly patients (HR: 0.46; 95% CI: 0.24-0.88; p = 0.0196).</P> <P><B>Conclusions</B></P> <P>Short-term DAPT after new-generation DES implantation may be more beneficial in elderly patients than in younger patients.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Passeri, Rosita,Aloisi, Gian Gaetano,Elisei, Fausto,Latterini, Loredana,Caronna, Tullio,Fontana, Francesca,Sora, Isabella Natali Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.11
In this work, three compounds having the same organic moiety (N-methyl-5-azahelicenium salts) but different counterions ($I^-$, $NO_3{^-}$ and $COOCF_3{^-}$) have been investigated in buffered aqueous solutions and in the presence of DNA to give information on the counterion effects on the binding. In particular, the absorption spectra, fluorescence quantum yields and fluorescence lifetimes in aqueous solution for free organic molecules have been determined by steady-state and time-resolved spectrofluorimetric measurements. The obtained values are compared with those of the chromophores in the presence of increasing concentrations of DNA. The results allow determination of the association constants ($K_a$) and the number of base couples per chromophore molecule (n) by means of the McGhee Von Hippel model. The binding parameters are strongly affected by the nature of counterions since the highest $K_a$ value was determined for the compound having $COOCF_3{^-}$; on the other hand the $NO_3{^-}$ derivative is able to interact with the highest number of binding sites. The morphology and structural properties of the DNA-chromophore complexes were investigated by circular dichroism (CD) and atomic force microscopy (AFM). The data revealed that $I^-$ and $COOCF_3{^-}$ derivatives preferentially form intercalation complexes, while the $NO_3{^-}$ salt is able to form intercalation and grove binding complexes at the same time.
Aortopulmonary Fistula Presenting without an Endoleak after Thoracic Endovascular Aortic Repair
Giacomo Sica,Gaetano Rea,Giorgio Bocchini,Romilda Lombardi,Massimo Muto,Tullio Valente 대한흉부외과학회 2017 Journal of Chest Surgery (J Chest Surg) Vol.50 No.4
Herein, we report the case of a 60-year-old man, a smoker with a history of arterial hypertension and diabetes mellitus. After computed tomography (CT) for an episode of hemoptysis, the patient underwent elective thoracic endovascular aortic repair (TEVAR) because of a degenerative aneurysm of the descending thoracic aorta. The area of perianeurysmal pulmonary atelectasis reported on the CT scan was not considered. Three months later, he developed an aortopulmonary fistula without endoleaks. Although TEVAR is a relatively safe procedure, no detail should be overlooked in the preoperative evaluation in order to avoid life-threatening complications. Further, the effectiveness and modality of prolonged antibiotic prophylaxis and/or preoperative respiratory physiotherapy should be assessed in such cases.
Schnekenburger, Michael,Goffin, Eric,Lee, Jin-Young,Jang, Jun Young,Mazumder, Aloran,Ji, Seungwon,Rogister, Bernard,Bouider, Nafila,Lefranc, Florence,Miklos, Walter,Mathieu, Vé,ronique,de Tullio American Chemical Society 2017 Journal of medicinal chemistry Vol.60 No.11
<P>A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. On the basis of computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea] which displays a potent anti.proliferative activity on various glioma cell types, assessed by quantitative videomicroscopy, eventually triggering senescence. The impact on normal glial cells was lower with a selectivity index of >10. Furthermore, human U373 and Hs683 glioblastoma cell lines served to demonstrate the inhibitory activity of 18 against histone deacetylase (HDAC) class III sirtuins 1 and 2 (SIRT1/2) by quantifying acetylation levels of histone and non-histone proteins. The translational potential of 18 was validated by an NCI-60 cell line screen and validation of growth inhibition of drug resistant cancer cell models. Eventually, the anticancer potential of 18 was validated- in 3D glioblastoma spheroids and in vivo by zebrafish xenografts. In summary, compound 18 is the first representative of a new class of SIRT inhibitors opening new perspectives in the medicinal chemistry of HDAC inhibitors.</P>