Outcomes of liver transplantation for hepatocellular carcinoma: Experiences from a Vietnamese center

Khai Viet Ninh,Dang Hai Do,Trung Duc Nguyen,Phuong Ha Tran,Tuan Hoang,Dung Thanh Le,Nghia Quang Nguyen 한국간담췌외과학회 2024 Annals of hepato-biliary-pancreatic surgery Vol.28 No.1

Backgrounds/Aims: Liver transplantation (LT) provides a favorable outcome for patients with hepatocellular carcinoma (HCC) and was launched in Vietnam in 2004. In this study, we evaluated the short-term and long-term outcomes of LT and its risk factors. Methods: This retrospective study analyzed HCC patients who underwent LT at Viet Duc University hospital, Vietnam, from 01/2012–03/2022. The following data were gathered: demographics, virus infection, tumor characteristics, alpha-fetoprotein (AFP) level, Child-Pugh and MELD scores, selection criteria, type of LT, complications, 30-day mortality, and disease-free and overall survival (DFS and OS). Results: Fifty four patients were included, the mean age was 55.39 ± 8.46 years. Nearly 90% had hepatitis B virus-related HCC. The median (interquartile range) AFP level was 16.2 (88.7) ng/mL. The average MELD score was 10.57 ± 5.95; the rate of Child-Pugh A and B were 70.4% and 18.5%, respectively. Nearly 40% of the patients were within Milan criteria, brain-dead donor was 83.3%. Hepatic and portal vein thrombosis occurred in 0% and 1.9%, respectively; hepatic artery thrombosis 1.9%, biliary leakage 5.6%, and postoperative hemorrhage 3.7%. Ninety-day mortality was 5.6%. Five-year DFS and OS were 79.3% and 81.4%, respectively. MELD score and Child- Pugh score were predictive factors for DFS and OS (p < 0.05). In multivariate analysis, Child-Pugh score was the only significant factor (p < 0.05). Conclusions: In Vietnam, LT is an effective therapy for HCC with an acceptable complication rate, mortality rate, and good survival outcomes, and should be further encouraged.

Baseline susceptibility of Asian corn borer (Ostrinia furnacalis (Guenée)) populations in Vietnam to Cry1Ab insecticidal protein

Duc Khanh Le,Quang Khai Le,Thi Thuy Hang Tran,Duc Viet Nguyen,Thi Hang Dao,Thi Thuy Nguyen,Xuan Lam Truong,Quang Cuong Nguyen,Huy Phong Pham,Thi Thu Thuy Phan,Gajendra Babu Baktavachalam 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.2

Susceptibility of Asian corn borer (ACB), Ostrinia furnacalis (Guenée) to Bacillus thuringiensis (Bt) Cry1Ab protein was studied between 2015 and 2016 with 11 ACB populations, collected from various geographical regions in Vietnam. A concentration range of Cry1Ab from 0.20 to 26.10 ng/cm 2 of diet was evaluated against F 1 ACB neonates using diet surface-overlay bioassays. Mortality data was recorded daily until seven days after infestation. Growth inhibition was recorded at the end of seven days. The median lethal concentration (LC 50 ) varied ≈3-fold among the different populations, ranging from 0.58 to 1.83 ng/cm 2 of diet with an overall mean of 0.86 ng/cm 2 of diet. Even the lowest concentration of 0.20 ng/cm 2 caused 73.53% growth inhibition. > 90% growth inhibition was achieved at 0.82 ng/cm 2 or higher concentrations. The results reflect natural variation in Bt susceptibility among ACB populations rather than variation caused by prior exposure to selection pressures. LC 99 value (17.26 ng/cm 2 ) was generated by pooling mortality data across different populations. The upper fiducial limit of LC 99 (24.38 ng/cm 2 ) could be a potential diagnostic dose for future resistance monitoring programs. The findings from this study suggest that ACB populations in Vietnam are highly susceptible to Cry1Ab protein. This is the first report of Cry1Ab susceptibility of different ACB populations in Vietnam and will serve as a baseline for future resistance monitoring work.

An improvement of real-time polymerase chain reaction system based on probe modification is required for accurate detection of African swine fever virus in clinical samples in Vietnam

Tran Ha Thi Thanh,Dang Anh Kieu,Ly Duc Viet,Vu Hao Thi,Hoang Tuan Van,Nguyen Chinh Thi,Chu Nhu Thi,Nguyen Vinh The,Nguyen Huyen Thi,Truong Anh Duc,Pham Ngoc Thi,Dang Hoang Vu 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.10

Objective: The rapid and reliable detection of the African swine fever virus (ASFV) plays an important role in emergency control and preventive measures of ASF. Some methods have been recommended by FAO/OIE to detect ASFV in clinical samples, including real-time polymerase chain reaction (PCR). However, mismatches in primer and probe binding regions may cause a false-negative result. Here, a slight modification in probe sequence has been conducted to improve the qualification of real-time PCR based on World Organization for Animal Health (OIE) protocol for accurate detection of ASFV in field samples in Vietnam. Methods: Seven positive confirmed samples (four samples have no mismatch, and three samples contained one mutation in probe binding sites) were used to establish novel real-time PCR with slightly modified probe (Y = C or T) in comparison with original probe recommended by OIE. Results: Both real-time PCRs using the OIE-recommended probe and novel modified probe can detect ASFV in clinical samples without mismatch in probe binding site. A high correlation of cycle quantification (Cq) values was observed in which Cq values obtained from both probes arranged from 22 to 25, suggesting that modified probe sequence does not impede the qualification of real-time PCR to detect ASFV in clinical samples. However, the samples with one mutation in probe binding sites were ASFV negative with OIE recommended probe but positive with our modified probe (Cq value ranked between 33.12-35.78). Conclusion: We demonstrated for the first time that a mismatch in probe binding regions caused a false negative result by OIE recommended real-time PCR, and a slightly modified probe is required to enhance the sensitivity and obtain an ASF accurate diagnosis in field samples in Vietnam.

A new empirical formula for prediction of the axial compression capacity of CCFT columns

Viet-Linh Tran,Duc Kien Thai,김승억 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.33 No.2

This paper presents an efficient approach to generate a new empirical formula to predict the axial compression capacity (ACC) of circular concrete-filled tube (CCFT) columns using the artificial neural network (ANN). A total of 258 test results extracted from the literature were used to develop the ANN models. The ANN model having the highest correlation coefficient (<i>R</i>) and the lowest mean square error (<i>MSE</i>) was determined as the best model. Stability analysis, sensitivity analysis, and a parametric study were carried out to estimate the stability of the ANN model and to investigate the main contributing factors on the ACC of CCFT columns. Stability analysis revealed that the ANN model was more stable than several existing formulae. Whereas, the sensitivity analysis and parametric study showed that the outer diameter of the steel tube was the most sensitive parameter. Additionally, using the validated ANN model, a new empirical formula was derived for predicting the ACC of CCFT columns. Obviously, a higher accuracy of the proposed empirical formula was achieved compared to the existing formulae.

관상동맥 협착병변 형상인자와 혈류역학 기반 진단인자의 상관관계 수치해석 연구

쩐득민(Duc Minh Tran),웬비엣카이(Viet Khai Nguyen),웬민투안(Minh Tuan Nguyen),이상욱(Sang-Wook Lee) 대한기계학회 2018 大韓機械學會論文集B Vol.42 No.7

관상동맥 협착병변 심각도에 대한 기존의 혈관 협착률 기반 진단인자의 제한된 정확도로 인하여 최근 생리기능성 진단인자의 중요성이 높아지고 있다. 가장 대표적인 혈류역학 기반 생리기능성 진단인자인 심근분획혈류예비력(FFR)과 벽전단응력(WSS)가 일반적으로 협착병변의 여러 형상 특성인자에 의해 크게 영향을 받는 것으로 잘 알려져 있다. 본 연구에서는 협착병변의 다양한 형상특성인자를 고려한 혈관 모델을 설계하고 다중스케일 CFD 시뮬레이션을 수행한 후, FFR 및 WSS값과 협착병변 형상특성인자의 상관관계를 분석하였다. 기본적으로 혈관 협착률이 FFR과 WSS값에 가장 큰 영향을 미치는 것으로 나타났으며, 협착률이 높을수록, 협착부 형상(shape)의 영향이 커짐을 확인할 수 있었다. Due to the limited diagnostic accuracy of conventional evaluation by stenosis degree for coronary stenotic lesion severity, physiology-based functional indices have recently received much attention. Fractional flow reserve (FFR) and wall shear stress (WSS) are the most representative indices. These hemodynamics-based indices are closely related to blood flow characteristics downstream of stenosis which is greatly affected by the geometric features of stenosis. In this study, we considered major geometric features of stenotic lesions and investigated the correlation between the functional indices and the lesion-specific geometrical parameters by carrying out multi-scale CFD simulations. Lumen diameter reduction rate has the largest effect on the physiological indices and the effect of lesion shape becomes greater as the stenosis degree rises.

An adaptive approach for the chloride diffusivity of cement-based materials

Bao-Viet Tran,Duc-Chinh Pham,Mai-Dinh Loc,Minh-Cuong Le 사단법인 한국계산역학회 2019 Computers and Concrete, An International Journal Vol.23 No.2

Adaptive schemes are constructed in this paper for modeling the effective chloride diffusion coefficient of cementbased materials (paste and concrete). Based on the polarization approximations for the effective conductivity of isotropic multicomponent materials, we develop some fitting procedures to include more information about the materials, to improve the accuracy of the scheme. The variable reference parameter of the approximation involves a few free scalars, which are determined through the available numerical or experimental values of the macroscopic chloride diffusion coefficient of cement paste or concrete at some volume proportions of the component materials. The various factors that affect the chloride diffusivity of cement-based material (porous material structure, uncertainty of value of the chloride diffusion coefficient in water-saturated pore spaces, etc.) may be accounted to make the predictions more accurate. Illustrations of applications are provided in a number of examples to show the usefulness of the approach.

Critical Behavior in La_0.75Ca_0.2Ag_0.05MnO₃ Exhibiting the Griffiths Phase

Thanh, Tran Dang,Huyen Yen, Pham Duc,Hau, Kieu Xuan,Bau, Le Viet,Yu, S. C. IEEE 2018 IEEE transactions on magnetics Vol.54 No.11

<P>In this paper, we have investigated the critical properties in the vicinity of the ferromagnetic (FM)–paramagnetic (PM) phase transition in a polycrystalline sample of La<SUB>0.75</SUB>Ca<SUB>0.2</SUB>Ag<SUB>0.05</SUB>MnO<SUB>3</SUB>, which was prepared by a solid-state reaction method. Temperature dependence of the inverse of the susceptibility <TEX>$\chi ^{-1}$</TEX> ( <TEX>$T$</TEX>) proves an existence of the Griffiths phase well above Curie temperature ( <TEX>$T_{C} = 230$</TEX> K). Detailed analyses of the isothermal magnetization <TEX>$M$</TEX>( <TEX>$H$</TEX>, <TEX>$T$</TEX>) data reveal the sample exhibiting a second-order magnetic phase transition, and its temperature dependences of the saturation magnetization and the initial susceptibility obey the asymptotic relations. Using the modified Arrott plots method, the Kouvel–Fisher method, and the critical isotherm analysis, the critical parameters ( <TEX>$\beta$</TEX>, <TEX>$\gamma$</TEX>, <TEX>$\delta$</TEX>, and <TEX>$T_{C}$</TEX>) of La<SUB>0.75</SUB>Ca<SUB>0.2</SUB>Ag<SUB>0.05</SUB>MnO<SUB>3</SUB> compound have been estimated. Using these critical exponent values, almost <TEX>$M$</TEX>( <TEX>$H$</TEX>, <TEX>$T$</TEX>) data measured at different temperatures around FM–PM phase transition are collapsed onto two universal curves of <TEX>$M/\vert \varepsilon \vert ^{\boldsymbol {\beta }}$</TEX> versus <TEX>$H/\vert \varepsilon \vert ^{\boldsymbol {\beta }+\boldsymbol {\gamma }}$</TEX> corresponding to the regular functions for <TEX>$T > T_{C}$</TEX> and <TEX>$T < T_{C}$</TEX>, respectively.</P>

Travel Intention to Visit Tourism Destinations: A Perspective of Generation Z in Vietnam

NGUYEN, Viet Hoang,TRUONG, Thi Xuan Dao,PHAM, Huong Trang,TRAN, Duc Thanh,NGUYEN, Pham Hung Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2

The purpose of this research is to investigate the impacts of gen-Z's perception of consumer-generated content on social media on their travel intention with the mediating role of travel motivation push and pull. An online questionnaire survey of a total of 369 samples was conducted with the participation of gen Z in the most important cities across Vietnam. The model was analyzed using Structural Equation Modeling (SEM) using AMOS program 22 to investigate model relationships and all hypotheses are significant. The findings indicated that gen Z values the usefulness of social media and they use social media for knowledge-seeking (push factor), and this leads to their intention to visit a destination. SEM analysis also reveals that gen Z tends to use social media to find accessibility to any destinations and they are motivated highly with destinations that have clear and easy access, for example, no visa requirement or neighboring destinations. As the result, they have better intentions to visit these destinations. This research will help marketers, especially marketing specialists to gain a better understanding of gen Z, thus implement better marketing techniques to target gen Z.

Magnetic and magnetocaloric properties in second-order phase transition La_1−xK_xMnO₃ and their composites

Thanh, Tran Dang,Linh, Dinh Chi,Yen, Pham Duc Huyen,Bau, Le Viet,Ky, Vu Hong,Wang, Zhihao,Piao, Hong-Guang,An, Nguyen Manh,Yu, Seong-Cho Elsevier 2018 PHYSICA B-CONDENSED MATTER - Vol.532 No.-

<P><B>Abstract</B></P> <P>In this work, we present a detailed study on the magnetic properties and the magnetocaloric effect (MCE) of La<SUB>1−x</SUB>K<SUB>x</SUB>MnO<SUB>3</SUB> compounds with <I>x</I>=0.05–0.2. Our results pointed out that the Curie temperature (<I>T</I> <SUB>C</SUB>) could be controlled easily from 213 to 306K by increasing K-doping concentration (<I>x</I>) from 0.05 to 0.2. In the paramagnetic region, the inverse of the susceptibility can be analyzed by using the Curie-Weiss law, <I>χ</I>(<I>T</I>)=<I>C</I>/(<I>T</I>−<I>θ</I>). The results have proved an existence of ferromagnetic clusters at temperatures above <I>T</I> <SUB>C</SUB>. Based on Banerjee's criteria, we also pointed out that the samples are the second-order phase transition materials. Their magnetic entropy change was calculated by using the Maxwell relation and a phenomenological model. Interestingly, the samples with <I>x</I>=0.1–0.2 exhibit a large MCE in a range of 282–306K, which are suitable for room-temperature magnetic refrigeration applications. The composites obtained from single phase samples (<I>x</I>=0.1–0.2) exhibit the high relative cooling power values in a wide temperature range. From the viewpoint of the refrigerant capacity, the composites formed out of La<SUB>1−x</SUB>K<SUB>x</SUB>MnO<SUB>3</SUB> will become more useful for magnetic refrigeration applications around room-temperature.</P>

Chicken novel leukocyte immunoglobulin-like receptor subfamilies B1 and B3 are transcriptional regulators of major histocompatibility complex class I genes and signaling pathways

Anh Duc Truong,홍여진,이장근,이경백,Ha Thi Thanh Tran,Hoang Vu Dang,Viet Khong Nguyen,Hyun S. Lillehoj,홍영호 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.5

Objective: The inhibitory leukocyte immunoglobulin-like receptors (LILRBs) play an important role in innate immunity. The present study represents the first description of the cloning and structural and functional analysis of LILRB1 and LILRB3 isolated from two genetically disparate chicken lines. Methods: Chicken LILRB1-3 genes were identified by bioinformatics approach. Expression studies were performed by transfection, quantitative polymerase chain reaction. Signal transduction was analyzed by western blots, immunoprecipitation and flow cytometric. Cytokine levels were determined by enzyme-linked immunosorbent assay. Results: Amino acid homology and phylogenetic analyses showed that the homologies of LILRB1 and LILRB3 in the chicken line 6.3 to those proteins in the chicken line 7.2 ranged between 97%-99%, while homologies between chicken and mammal proteins ranged between 13%-19%, and 13%-69%, respectively. Our findings indicate that LILRB1 and LILRB3 subdivided into two groups based on the immunoreceptor tyrosine-based inhibitory motifs (ITIM) present in the transmembrane domain. Chicken line 6.3 has two ITIM motifs of the sequence LxYxxL and SxYxxV while line 7.2 has two ITIM motifs of the sequences LxYxxL and LxYxxV. These motifs bind to SHP-2 (protein tyrosine phosphatase, non-receptor type 11) that plays a regulatory role in immune functions. Moreover, our data indicate that LILRB1 and LILRB3 associated with and activated major histocompatibility complex (MHC) class I and β2-microglobulin and induced the expression of transporters associated with antigen processing, which are essential for MHC class I antigen presentation. This suggests that LILRB1 and LILRB3 are transcriptional regulators, modulating the expression of components in the MHC class I pathway and thereby regulating immune responses. Furthermore, LILRB1 and LILRB3 activated Janus kinase2/tyrosine kinase 2 (JAK2/TYK2); signal transducer and activator of transcription1/3 (STAT1/3), and suppressor of cytokine signaling 1 genes expressed in Macrophage (HD11) cells, which induced Th1, Th2, and Th17 cytokines. Conclusion: These data indicate that LILRB1 and LILRB3 are innate immune receptors associated with SHP-2, MHC class I, β2-microglobulin, and they activate the Janus kinase/signal transducer and activator of transcription signaling pathway. Thus, our study provides novel insights into the regulation of immunity and immunopathology.