Development and Implementation of Training Program for Information System Design Using Material Requirements Planning

Tomoaki Yamazaki,Rui Yin,Seisuke Kawaguchi,Hirotatsu Hayasaka,Toshiyuki Matsumoto,Osamu Ichikizaki,Takashi Kanazawa 대한산업공학회 2012 Industrial Engineeering & Management Systems Vol.11 No.3

Environments surrounding production sites have changed greatly in recent years. Accommodating environmental changes calls for the design and development of information systems that center on production lines. There is a need for a training program that teaches learners to understand the particulars of an operation and apply that knowledge to an information system. In this research, we used material requirements planning (MRP) as the subject for which basic skills are to be taught and developed an MRP exercise-based training program. The program is designed for 13 lectures of 90 minutes each, and it consists of MRP exercises, modeling methods to represent them, the use of a programming language for system development, and finally, evaluation of the exercises. Lecture materials are described in 505 lecture slides using Microsoft PowerPoint to allow visualization of topics through graphs and models. The developed training program was then delivered to 86 college students, and its results were measured through quizzes to verify educational effectiveness.

A Case of Multicentric Castleman’s Disease Having Lung Lesion Successfully Treated with Humanized Anti-interleukin-6 Receptor Antibody, Tocilizumab

Tomoaki Higuchi,Takashi Nakanishi,Kunio Takada,Mitsuyo Matsumoto,Makoto Okada,Hideyuki Horikoshi,Kimihiro Suzuki 대한의학회 2010 Journal of Korean medical science Vol.25 No.9

This report presents the case of a patient demonstrating multicentric Castleman’s disease (MCD) with a lung lesion that was successfully treated with an anti-interleukin-6 receptor antibody, tocilizumab in combination with corticosteroid and tacrolimus. A 43-yr-old female with abnormal shadows on a chest X-ray was referred to the hospital for further examination. She was diagnosed as having MCD based on the characteristic pathology of inguinal lymph node, lung lesions, laboratory data, and undifferentiated arthritis. Corticosteroid and rituximab therapy did not fully ameliorate the symptoms; thus, the therapeutic regimen was changed to include tocilizumab, oral corticosteroid and tacrolimus. This regimen resulted in clinical remission and the dose of tocilizumab and corticosteroid could be tapered. Tocilizumab in combination with corticosteroid and tacrolimus may therefore be a beneficial treatment regimen for lung lesions associated with MCD.

Development and Implementation of Training Program for Information System Design Using Material Requirements Planning

Yamazaki, Tomoaki,Yin, Rui,Kawaguchi, Seisuke,Hayasaka, Hirotatsu,Matsumoto, Toshiyuki,Ichikizaki, Osamu,Kanazawa, Takashi Korean Institute of Industrial Engineers 2012 Industrial Engineeering & Management Systems Vol.11 No.3

Environments surrounding production sites have changed greatly in recent years. Accommodating environmental changes calls for the design and development of information systems that center on production lines. There is a need for a training program that teaches learners to understand the particulars of an operation and apply that knowledge to an information system. In this research, we used material requirements planning (MRP) as the subject for which basic skills are to be taught and developed an MRP exercise-based training program. The program is designed for 13 lectures of 90 minutes each, and it consists of MRP exercises, modeling methods to represent them, the use of a programming language for system development, and finally, evaluation of the exercises. Lecture materials are described in 505 lecture slides using Microsoft PowerPoint to allow visualization of topics through graphs and models. The developed training program was then delivered to 86 college students, and its results were measured through quizzes to verify educational effectiveness.

TURBULENCE PRODUCED BY TSUNAMIS IN GALAXY CLUSTERS

FUJITA YUTAKA,MATSUMOTO TOMOAKI,WADA KEIICHI The Korean Astronomical Society 2004 Journal of The Korean Astronomical Society Vol.37 No.5

Clusters of galaxies are filled with X-ray emitted hot gas with the temperature of T ${\~}$2-10 keV. Recent X-ray observations have been revealing unexpectedly that many cluster cores have complicated, peculiar X-ray structures, which imply dynamical motion of the hot gas. Moreover, X-ray spectra indicate that radiative cooling of the cool gas is suppressed by unknown heating mechanisms (the 'cooling flow problem'). Here we propose a novel mechanism reproducing both the inhomogeneous structures and dynamics of the hot gas in the cluster cores, based on state-of-the-art hydrodynamic simulations. We showed that acoustic-gravity waves, which are naturally expected during the process of hierarchical structure formation of the universe, surge in the X-ray hot gas, causing a serous impact on the core. This reminds us of tsunamis on the ocean surging into an distant island. We found that the waves create fully-developed, stable turbulence, which reproduces the complicated structures in the core. Moreover, if the wave amplitude is large enough, they can suppress the cooling of the core. The turbulence could be detected in near-future space X-ray missions such as ASTRO-E2.

Attenuated Allergenic Activity of Ovomucoid After Electrolysis

Jun Kido,Tomoaki Matsumoto 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.6

Ovomucoid (OMC) is the most prominent allergen causing hen’s egg allergy, containing disulfide (S-S) bonds that may be responsible for its allergic action. As S-S bonds may be reduced during electrolysis, this study was undertaken to evaluate modulation of the allergic action of OMC after electrolysis. Electrolysis was carried out for 1% OMC containing 1% sodium chloride for 30 minutes with a voltage difference of 90 V, 0.23 A (30 mA/ cm2). Protein assays, amino acid measurement, and mass spectrometry in untreated OMC and OMC on both the anode and cathode sides after electrolysis were performed. Moreover, 21 patients with IgE-mediated hen’s egg allergy were evaluated by using the skin prick test (SPT) for untreated OMC and OMC after electrolysis. The allergic action of OMC was reduced after electrolysis on both the anode and cathode sides when evaluated by the SPT. The modifications of OMC on electrolysis caused the loss of 2 distinct peptide fragments (57E-63K and 123H-128R) as seen on matrixassociated laser desorption/ionization time-of-flight mass spectrometry. The total free SH groups in OMC were increased on the cathode side. Although the regions of S-S broken bonds were not determined in this study, the change in S-S bonds in OMC on both the anode and cathode sides may reduce the allergenic activity.

Defective natural killer cell activity in a mouse model of eczema herpeticum

Kawakami, Yuko,Ando, Tomoaki,Lee, Jong-Rok,Kim, Gisen,Kawakami, Yu,Nakasaki, Tae,Nakasaki, Manando,Matsumoto, Kenji,Choi, Youn Soo,Kawakami, Toshiaki Elsevier 2017 The journal of allergy and clinical immunology Vol.139 No.3

<P><B>Background</B></P> <P>Patients with atopic dermatitis (AD) are susceptible to several viruses, including herpes simplex virus (HSV). Some patients experience 1 or more episodes of a severe skin infection caused by HSV termed eczema herpeticum (EH). There are numerous mouse models of AD, but no established model exists for EH.</P> <P><B>Objective</B></P> <P>We sought to establish and characterize a mouse model of EH.</P> <P><B>Methods</B></P> <P>We infected AD-like skin lesions with HSV1 to induce severe skin lesions in a dermatitis-prone mouse strain of NC/Nga. Gene expression was investigated by using a microarray and quantitative PCR; antibody titers were measured by means of ELISA; and natural killer (NK) cell, cytotoxic T-cell, regulatory T-cell, and follicular helper T-cell populations were evaluated by using flow cytometry. The role of NK cells in HSV1-induced development of severe skin lesions was examined by means of depletion and adoptive transfer.</P> <P><B>Results</B></P> <P>Inoculation of HSV1 induced severe erosive skin lesions in eczematous mice, which had an impaired skin barrier, but milder lesions in small numbers of normal mice. Eczematous mice exhibited lower NK cell activity but similar cytotoxic T-cell activity and humoral immune responses compared with normal mice. The role of NK cells in controlling HSV1-induced skin lesions was demonstrated by experiments depleting or transferring NK cells.</P> <P><B>Conclusion</B></P> <P>A murine model of EH with an impaired skin barrier was established in this study. We demonstrated a critical role of defective NK activities in the development of HSV1-induced severe skin lesions in eczematous mice.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

ORiginal Article : Feasibility, Efficacy, and Predictive Factors for the Technical Success of Endoscopic Nasogallbladder Drainage: A Prospective Study

( Kei Yane ),( Hiroyuki Maguchi ),( Akio Katanuma ),( Kuniyuki Takahashi ),( Manabu Osanai ),( Toshifumi Kin ),( Ryo Takaki ),( Kazuyuki Matsumoto ),( Katsushige Gon ),( Tomoaki Matsumori ),( Akiko To The Editorial Office of Gut and Liver 2015 Gut and Liver Vol.9 No.2

Background/Aims: Several studies have shown the usefulness of endoscopic nasogallbladder drainage (ENGBD) in patients with acute cholecystitis. However, the procedure is difficult, and factors that affect technical success have not yet been clarified. We conducted a prospective study to evaluate the technical feasibility, efficacy, and predictive factors for the technical success of ENGBD in patients with acute cholecystitis. Methods: All patients with moderate or severe acute cholecystitis who were enrolled underwent ENGBD between April 2009 and April 2011. Patients with surgically altered anatomy or pancreatobiliary malignancies were excluded. The primary outcomes included technical success, clinical success, and complications. Factors that could affect the technical success were also examined. Results: Of the 27 patients who underwent ENGBD during the study period, technical success was achieved in 21 (78%) and clinical improvement was achieved in 20 (95%). Early complications were encountered in four patients (15%). Gallbladder wall thickness (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.08 to 2.47) and age (OR, 1.16; 95% CI, 1.00 to 1.35) were effective predictors of technical failure. Conclusions: ENGBD was effective in resolving acute cholecystitis; however, this modality was technically challenging and had a limited success rate. Because of technical difficulties, ENGBD should be reserved for limited indications. (Gut Liver, 2015;9:239-246)