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A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
Claire Hall,Louise Clarke,Atanu Pal,Pamela Buchwald,Tim Eglinton,Chris Wakeman,Frank Frizelle 대한대장항문학회 2019 Annals of Coloproctolgy Vol.35 No.6
Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.
When outbound mobility programs and service learning align in pre-service teacher education
Anne Power,Son Truong,Tonia Gray,Greg Downey,Tim Hall,Benjamin Jones 서울대학교 교육연구소 2017 Asia Pacific Education Review Vol.18 No.3
This project sought to investigate the learning that comes about from the intersection of outbound mobility experience programs (OMEs) with service learning in pre-service teacher education settings. The aim of the program of international service learning in the case study was to encourage pre-service teachers to rethink potentially ethnocentric assumptions. The guiding research question was, ‘What outcomes ensue from the combination of OMEs and service learning for pre-service teachers?’ The focus of the paper was on OMEs that took place in China and Malaysia. Findings included that the combined program aided development of global mindedness, learning by being there, teacher experience in a new context and the development of a professional identity in the participating students.