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Vu, Tien V.,Kim, Nam,Shin, Chang-Won 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.3
A new structure of polarization-selective elements consisting of two holographic gratings and a dove prism coupler is proposed. The absence of a multi-stage wave-guide, compact size, and lightweight volume are the outstanding features of the new structure. Based on the coupled-wave theory, the analysis and design of the structure are discussed in detail to calculate the required index modulation. Several parameters such as the recording intensity, the exposure time, and the recording angles for the fabrication of the proposed element are determined. Under the conditions the element is fabricated in Dupont photopolymer HRF-150-38 material and with the operating wavelength of 532 nm. A simplified pick-up head is constructed to evaluate the performance of the fabricated element.
Design, synthesis and biological evaluation of novel hydroxamic acids bearing artemisinin skeleton
Ha, V.T.,Kien, V.T.,Binh, L.H.,Tien, V.D.,My, N.T.T.,Nam, N.H.,Baltas, M.,Hahn, H.,Han, B.W.,Thao, D.T.,Vu, T.K. Academic Press ; Academic Press 2016 Bioorganic chemistry Vol.66 No.-
<P>A series of novel hydroxamic acids bearing artemisinin skeleton was designed and synthesized. Some compounds in this series exhibited moderate inhibition against the whole cell HDAC enzymes. Especially, compound 6g displayed potent cytotoxicity against three human cancer cell lines, including HepG2 (liver cancer), MCF-7 ( breast cancer) and HL-60 (leukemia cancer), with IC50 values of 2.50, 2.62 and 1.28 mu g/mL, respectively. Docking studies performed with two potent compounds 6a and 6g using Autodock Vina showed that both compounds bound to HDAC2 with relatively high binding affinities from -7.1 to 7.0 kcal/mol compared to SAHA (-7.4 kcal/mol). It was found in this research that most of the target compounds seemed to be more cytotoxic toward blood cancer cells (HL-60) than liver (HepG2), and breast (MCF-7) cancer cells. (C) 2016 Elsevier Inc. All rights reserved.</P>