Partially linear multivariate regression in the presence of measurement error

Yalaz, Secil,Tez, Mujgan The Korean Statistical Society 2020 Communications for statistical applications and me Vol.27 No.5

In this paper, a partially linear multivariate model with error in the explanatory variable of the nonparametric part, and an m dimensional response variable is considered. Using the uniform consistency results found for the estimator of the nonparametric part, we derive an estimator of the parametric part. The dependence of the convergence rates on the errors distributions is examined and demonstrated that proposed estimator is asymptotically normal. In main results, both ordinary and super smooth error distributions are considered. Moreover, the derived estimators are applied to the economic behaviors of consumers. Our method handles contaminated data is founded more effectively than the semiparametric method ignores measurement errors.

Risk of Estrogen Receptor-Positive and -Negative Breast Cancer and Single-Nucleotide Polymorphism 2q35-rs13387042

Milne, Roger L.,Bení,tez, Javier,Nevanlinna, Heli,Heikkinen, Tuomas,Aittomä,ki, Kristiina,Blomqvist, Carl,Arias, José,Ignacio,Zamora, M. Pilar,Burwinkel, Barbara,Bartram, Claus R.,Mein Oxford University Press 2009 Journal of the National Cancer Institute Vol.101 No.14

<P>BACKGROUND: A recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)-positive breast cancer. We attempted to confirm this association using the Breast Cancer Association Consortium. METHODS: 2q35-rs13387042 SNP was genotyped for 31 510 women with invasive breast cancer, 1101 women with ductal carcinoma in situ, and 35 969 female control subjects from 25 studies. Odds ratios (ORs) were estimated by logistic regression, adjusted for study. Heterogeneity in odds ratios by each of age, ethnicity, and study was assessed by fitting interaction terms. Heterogeneity by each of invasiveness, family history, bilaterality, and hormone receptor status was assessed by subclassifying case patients and applying polytomous logistic regression. All statistical tests were two-sided. RESULTS: We found strong evidence of association between rs13387042 and breast cancer in white women of European origin (per-allele OR = 1.12, 95% confidence interval [CI] = 1.09 to 1.15; P(trend) = 1.0 x 10(-19)). The odds ratio was lower than that previously reported (P = .02) and did not vary by age or ethnicity (all P > or = .2). However, it was higher when the analysis was restricted to case patients who were selected for a strong family history (P = .02). An association was observed for both ER-positive (OR = 1.14, 95% CI = 1.10 to 1.17; P = 10(-15)) and ER-negative disease (OR = 1.10, 95% CI = 1.04 to 1.15; P = .0003) and both progesterone receptor (PR)-positive (OR = 1.15, 95% CI = 1.11 to 1.19; P = 5 x 10(-14)) and PR-negative disease (OR = 1.10, 95% CI = 1.06 to 1.15; P = .00002). CONCLUSION: The rs13387042 is associated with both ER-positive and ER-negative breast cancer in European women.</P>

Prognostic Value of Preoperative Inflammation-Based Prognostic Scores on Hospital Mortality after Gastric Cancer Surgery

Dinc, Tolga,Yildiz, Baris Dogu,Kayilioglu, Ilgaz,Sozen, Isa,Tez, Mesut,Coskun, Faruk Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Gastric cancer is the fourth most common malignancy worldwide. Poor prognosis in gastric cancer is linked with hypoalbuminemia. Previous studies demonstrated relationships between gastric cancer and chronic inflammation. The aim of this study was to assess the prognostic value of preoperative inflammation-based prognostic scores regarding hospital mortality after gastrectomy. Unlike other recent articles on the same topic; we could only verify prognostic value of prognostic nutritional index for in hospital mortality after surgery.

Solution-Phase MechanisticStudy and Solid-State Structureof a Tris(bipyridinium radical cation) Inclusion Complex

Fahrenbach, AlbertC.,Barnes, Jonathan C.,Lanfranchi, Don Antoine,Li, Hao,Coskun, Ali,Gassensmith, Jeremiah J.,Liu, Zhichang,Bení,tez, Diego,Trabolsi, Ali,Goddard, William A.,Elhabiri, Mourad,Sto American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.6

<P>The ability of the diradical dicationic cyclobis(paraquat-<I>p</I>-phenylene) (CBPQT<SUP>2(•+)</SUP>) ring to forminclusion complexes with 1,1′-dialkyl-4,4′-bipyridiniumradical cationic (BIPY<SUP>•+</SUP>) guests has been investigatedmechanistically and quantitatively. Two BIPY<SUP>•+</SUP> radicalcations, methyl viologen (MV<SUP>•+</SUP>) and a dibutynylderivative (V<SUP>•+</SUP>), were investigated as guests forthe CBPQT<SUP>2(•+)</SUP> ring. Both guests form trisradicalcomplexes, namely, CBPQT<SUP>2(•+)</SUP>⊂MV<SUP>•+</SUP> and CBPQT<SUP>2(•+)</SUP>⊂V<SUP>•+</SUP>, respectively.The structural details of the CBPQT<SUP>2(•+)</SUP>⊂MV<SUP>•+</SUP> complex, which were ascertained by single-crystalX-ray crystallography, reveal that MV<SUP>•+</SUP> is locatedinside the cavity of the ring in a centrosymmetric fashion: the 1:1complexes pack in continuous radical cation stacks. A similar solid-statepacking was observed in the case of CBPQT<SUP>2(•+)</SUP> byitself. Quantum mechanical calculations agree well with the superstructurerevealed by X-ray crystallography for CBPQT<SUP>2(•+)</SUP>⊂MV<SUP>•+</SUP> and further suggest an electronicasymmetry in the SOMO caused by radical-pairing interactions. Theelectronic asymmetry is maintained in solution. The thermodynamicstability of the CBPQT<SUP>2(•+)</SUP>⊂MV<SUP>•+</SUP> complex was probed by both isothermal titration calorimetry (ITC)and UV/vis spectroscopy, leading to binding constants of (5.0 ±0.6) × 10<SUP>4</SUP> M<SUP>–1</SUP> and (7.9 ± 5.5)× 10<SUP>4</SUP> M<SUP>–1</SUP>, respectively. The kineticsof association and dissociation were determined by stopped-flow spectroscopy,yielding a <I>k</I><SUB>f</SUB> and <I>k</I><SUB>b</SUB> of (2.1 ± 0.3) × 10<SUP>6</SUP> M<SUP>–1</SUP> s<SUP>–1</SUP> and 250 ± 50 s<SUP>–1</SUP>, respectively.The electrochemical mechanistic details were studied by variable scanrate cyclic voltammetry (CV), and the experimental data were compareddigitally with simulated data, modeled on the proposed mechanism usingthe thermodynamic and kinetic parameters obtained from ITC, UV/vis,and stopped-flow spectroscopy. In particular, the electrochemicalmechanism of association/dissociation involves a bisradical tetracationicintermediate CBPQT<SUP>(2+)(•+)</SUP>⊂V<SUP>•+</SUP> inclusion complex; in the case of the V<SUP>•+</SUP> guest,the rate of disassociation (<I>k</I><SUB>b</SUB> = 10 ±2 s<SUP>–1</SUP>) was slow enough that it could be detectedand quantified by variable scan rate CV. All the experimental observationslead to the speculation that the CBPQT<SUP>(2+)(•+)</SUP> ringof the bisradical tetracation complex might possess the unique propertyof being able to recognize both BIPY<SUP>•+</SUP> radical cationand π-electron-rich guests simultaneously. The findings reportedherein lay the foundation for future studies where this radical–radicalrecognition motif is harnessed particularly in the context of mechanicallyinterlocked molecules and increases our fundamental understandingof BIPY<SUP>•+</SUP> radical–radical interactions insolution as well as in the solid-state.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-6/ja2089603/production/images/medium/ja-2011-089603_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja2089603'>ACS Electronic Supporting Info</A></P>

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Kayilioglu, Selami Ilgaz,Dinc, Tolga,Sozen, Isa,Senol, Kazim,Katar, Kagan,Karabeyoglu, Melih,Tez, Mesut,Coskun, Faruk Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Background: The Bethesda System for Reporting Thyroid Cytopathology is one of the main classification systems for thyroid nodules. It expects that 7% of all fine needle aspiration biopsies will be reported as atypia or follicular lesions of undetermined significance, and 5-15% of these undetermined nodules are malignant. Our study is a retrospective analysis of variables that may be associated with outcome in patients with indeterminate thyroid nodules. Materials and Methods: Patients who underwent thyroidectomy in our institution between 2010 and 2014 were retrieved from the institutional records database. Patient demographics and medical histories were recorded. All ultrasonography reports were examined for nodule features and biochemical blood levels, hormone levels and complete blood counts were recorded. Results: A total of 103 patient cytopathology reports were regarded as belonging to the undetermined category. Some 35% of patients had malignant nodules. Median preoperative red cell distribution width (RDW) level was 13.6 inthe benign group, while it was 14.3 in patients with malignancy, demonstrating a significant correlation (p=0.003). Only calcification presence was significantly different between benign and malignant groups on ultrasonography (p=0.034). Conclusions: Ultrasonography is one of the primary tools for this matter. RDW levels may become another promising tool to predict malignancy.

The Historic Cultural Heritage of the Spanish Colony in Mexico: Promotion of Religious Nationalism

Eva Leticia Brito Benítez,노용석 부경대학교 인문사회과학연구소 2019 인문사회과학연구 Vol.20 No.2

Mexican tangible and intangible cultural heritage (including paleontology and archeology, and historical customs and traditions) is protected by the Mexican government to strengthen national identity and historical memory, thereby strengthening national nationalism. Mexico's cultural heritage can be divided into three categories according to the history of Mexico, and they have different cultural characteristics. The first is the cultural heritage of mankind, which first lived in Central America, including Mexico, before the letter emerged. The second is that which comes from the original ethnic groups -that already had an important technological, scientific and artistic development- before the arrival of the Spaniards in America at the end of the 15th century including Azteca, Maya, and Inca culture. Finally, the third is the period after Spain and Portugal occupy the Latin American continent, including religious traditions and various cultural properties (including architecture, painting, sculpture, and books). The purpose of this paper is to analyze Mexican historical and cultural heritage included in the third colonial period, and describe how it relates to the formation of Mexican national identity and nationalism. During the Spanish colonial period, Spain has made considerable efforts to convert many indigenous into Catholicism, and what has been propagated in this process is the fusion of religion. Fusion religious attention, such as Virgen de Guadalupe, but in fact the two of indigenous beliefs and Catholicism combined. From a Mexican history, Virgen de Guadalupe served as a new identity in Mexico represent a "mestizo culture”, newly created after the colony. On the contrary, there are many religious buildings in Mexico, such as many cathedrals and monasteries built by the Spanish forces during the colonial period, which are only colonial heritage, but are now treated as cultural heritage by the Mexican government. This paper discusses how Spanish cultural heritage in Mexico can be identified as a cultural heritage in Mexico.

Religiosity in Mexico: The Cult of The Virgin of Guadalupe

Eva Leticia Brito Benítez,김소현,노용석 국립부경대학교 글로벌지역학연구소 2023 Journal of Global and Area Studies(JGA) Vol.7 No.4

To understand the religiosity and syncretism in the so-called Guadalupano phenomenon in Mexico, it is necessary to understand the historical veneration of the Earth goddess by ancient ethnic groups. Their religion was based on devotion to female and male deities of fertility and creation. The Mexicas, a group that settled in central Mexico, had a particular fervor for Tonantzin, which means “Our Mother” and tzin “respect” in Tonan. When the first Spanish friars arrived with an evangelizing mission and realized that the Christian doctrine meant nothing to the indigenous people, they looked for similarities between their old beliefs and the newly imposed religion. At the same time, the natives took advantage of this transmutation to keep their deities alive. Thus, in a merging of the goddess Tonantzin’s characteristics and the Virgin Mary’s attributions, Santa María de Guadalupe emerged. This image of motherhood is a product of a syncretic process characterized by the power of Christianity and indigenous resistance to domination. It is the Mexican Catholic population’s most important devotion and religious celebration.

멕시코 역사문화유산과 민족주의

Eva Leticia Brito Benítez,노용석 부경대학교 인문사회과학연구소 2019 인문사회과학연구 Vol.20 No.2

멕시코의 유형 및 무형 문화 유산 (고생물학과 고고학, 그리고 역사적인 관습 및 전통 을 포함)은 국가 정체성과 역사적 기억을 강화하기 위해 멕시코 정부에 의해 보호되고 있으며, 이를 통해 멕시코 정부는 국가 민족주의를 강화하고 있다. 멕시코 문화 유산은 멕시코의 역사에 따라 크게 세 개의 카테고리로 나눌 수 있으며, 이들은 각기 다른 문화 적 특징을 가지고 있다. 첫 번째는 문자 출현 이전의 시기로서 멕시코를 비롯한 중앙아메 리카 일대에 최초로 거주하였던 인류의 문화유산이 여기에 속한다. 두 번째는 15 세기 말 아메리카 대륙에 스페인 인이 도착하기 이전, 이미 중요한 기술적, 과학적 및 예술적 발전을 이룬 원주민 그룹들을 지칭하는 것으로서, 대개 마야와 잉카, 아스테카 원주민의 문화가 여기에 속한다. 마지막으로 세 번째는 스페인과 포르투갈이 라틴아메리카 대륙을 점령한 이후의 시기로서, 여기에는 주로 종교적 전통과 각종 문화재 (건축, 회화, 조각, 서적 등을 포함) 등이 포함되어 있다. 이 논문의 목적은 세 번째 식민지 시기에 포함된 멕시코 역사문화유산을 분석하고 있으며, 이것이 멕시코 국가정체성 및 민족주의를 형성 하는데 어떤 연관성을 가지고 있는가에 대해 서술하고 있다. 스페인 식민지 시기, 스페인 은 많은 원주민들을 카톨릭으로 개종하기 위해 상당한 노력을 기울였으며, 이러한 과정에 서 전파된 것이 종교의 융합주의이다. 과달루페 성모 신앙과 같은 융합종교주의는 사실상 원주민의 신앙과 카톨릭이 결합된 것이지만, 멕시코 역사에서 보자면 과달루페 성모 신앙 은 식민지 이후 새롭게 탄생한 ‘메스티소 문화’로 대변하는 멕시코의 새로운 정체성으로 작용하였다. 하지만 이와는 반대로 멕시코에는 식민지시기 스페인 세력이 건설한 많은 성 당과 수도원 등의 종교적 시설물이 존재하는데, 이것은 단지 식민지의 유산일뿐이지만 현 재 멕시코 정부에 의해 문화유산으로 취급받고 있다. 본 논문에서는 멕시코에 존재하는 스페인 종교 문화유산이 어떻게 멕시코의 문화유산으로 정체성을 가질 수 있는가에 대해 논의하고 있다. Mexican tangible and intangible cultural heritage (including paleontology and archeology, and historical customs and traditions) is protected by the Mexican government to strengthen national identity and historical memory, thereby strengthening national nationalism. Mexico's cultural heritage can be divided into three categories according to the history of Mexico, and they have different cultural characteristics. The first is the cultural heritage of mankind, which first lived in Central America, including Mexico, before the letter emerged. The second is that which comes from the original ethnic groups -that already had an important technological, scientific and artistic development- before the arrival of the Spaniards in America at the end of the 15th century including Azteca, Maya, and Inca culture. Finally, the third is the period after Spain and Portugal occupy the Latin American continent, including religious traditions and various cultural properties (including architecture, painting, sculpture, and books). The purpose of this paper is to analyze Mexican historical and cultural heritage included in the third colonial period, and describe how it relates to the formation of Mexican national identity and nationalism. During the Spanish colonial period, Spain has made considerable efforts to convert many indigenous into Catholicism, and what has been propagated in this process is the fusion of religion. Fusion religious attention, such as Virgen de Guadalupe, but in fact the two of indigenous beliefs and Catholicism combined. From a Mexican history, Virgen de Guadalupe served as a new identity in Mexico represent a "mestizo culture”, newly created after the colony. On the contrary, there are many religious buildings in Mexico, such as many cathedrals and monasteries built by the Spanish forces during the colonial period, which are only colonial heritage, but are now treated as cultural heritage by the Mexican government. This paper discusses how Spanish cultural heritage in Mexico can be identified as a cultural heritage in Mexico.

Acolman, Mexico: Fantastic Seahorses in a Catholic Church of the 16th Century

( Eva Leticia Brito Benítez ) 부경대학교 글로벌지역학연구소 2018 Journal of Global and Area Studies(JGA) Vol.2 No.1

The church, cloister and atrium of Acolman, Mexico, form an architectural group that was built by the friars of the order of Saint Augustine in the early 16^th century, a few years after the official consummation of the Spanish Conquest in 1521. It is a monastic-military construction decorated with reliefs and mural paintings that clearly reflect the objective of Christianizing the native population. The facade of the church has a plateresque style with a complex composition: columns with great decoration, sculptures of Church Fathers, cherubs, flora and fauna elements carved on stone. A row of representations of hybrid animals with marine and terrestrial characteristics, interpreted as seahorses or hippocampi was engraved under the frieze stands. The rarity of these elements led to the historic search for its iconographic meaning, finding its oldest sense in Phoenician culture, taken up by the Greek pagan bestiary, later resumed in Rome and from there it was taken up by Christianity that finally moved them to American lands through the Spaniards. The purpose of this document is to describe these fictitious marine beasts, to understand their ancient meaning and their role in the context of the first years of Catholic evangelization in Mexico that led to a process of religious syncretism that prevails until today. The method consisted of fieldwork in the locality of Acolman to study these elements; the theoretical research was based on bibliographic sources on history, art, architecture, and iconography. The results are published for the first time in this paper, clarifying that there is no specialized study on the topic of Acolman´s hippocampi in the literature. The research is part of the project Cultural-Historical Evaluation of the Collection of Paintings of the Ex Convent Museum of Acolman, State of Mexico, attached to the National Institute of Anthropology and History, which started in 2015 and has continued up to date.

Functional Gastrointestinal Disorders in Neonates and Toddlers According to the Rome IV Criteria: A Systematic Review and Meta-Analysis

Carlos Alberto Velasco-Benítez,Laura Isabel Collazos-Saa,Herney Andres García-Perdomo 대한소아소화기영양학회 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.5

Functional gastrointestinal disorders (FGIDs) are classified as a combination of persistent gastrointestinal symptoms. The Rome IV criteria can elucidate several factors in the pathogenesis of FGIDs. The frequency of FGIDs can differ between clinical and nonclinical settings and between geographic regions. To determine the global prevalence of FGIDs in neonates and toddlers according to the Rome IV criteria. We included cohort and descriptive observational studies reporting the prevalence of FGIDs according to the Rome IV criteria in children aged 0–48 months. We searched the Medline, Embase, Lilacs, and CENTRAL databases from May 2016 to the present day. Furthermore, unpublished literature was searched to supplement this information. The Strengthening the Reporting of Observational Studies in Epidemiology statement was used to evaluate the risk of bias. A meta-analysis of the proportions was performed using MetaProp in R. The results are reported in forest plots. We identified and analyzed 15 studies comprising 48,325 participants. Six studies were conducted in Europe, three in Latin America, two in North America, and four in Asia. Most participants were 12–48 months old (61.0%) and were recruited from the community. The global prevalence of FGIDs was 22.0% (95% confidence interval, 15–31%). The most common disorder was functional constipation (9.0%), followed by infant regurgitation syndrome (8.0%). Its prevalence was higher in the Americas (28.0%). FGIDs, as defined by the Rome IV criteria, are present in 22% of children, and the most common primary disorder is functional constipation. A higher prevalence of FGIDs has been reported in America.