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RISS 인기검색어
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- 저자 : Tannami Islam (검색결과 1 건)
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Mimi Golder,Samir Kumar Sadhu,Biswajit Biswas,Tannami Islam 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3
Ethanolic extracts of leaves and hypocotyls of a mangrove plant, Bruguiera gymnorrhiza (Family Rhizophoraceae), were investigated to identify the presence of different phytochemicals and to assess the antihyperglycemic, antidiarrheal, analgesic and antioxidative activity in the current study. Oral glucose tolerance test (OGTT) was performed to investigate the in vivo antihyperglycemic activity and leaves extract (LE) was found to possess significant antihyperglycemic property compared to hypocotyl extract (HE). Therefore, the leaves extract was considered for α-Glucosidase enzyme inhibitory activity test and substantial α-glucosidase enzyme inhibitory property was observed with an IC50 (concentration required to inhibit 50% enzyme) value of 2.670. Antioxidative activity of plant extracts was tested in vitro by evaluating their ability to scavenge DPPH, hydrogen peroxide and hydroxyl radical as well as superoxide anions. In all cases, LE showed greater activity than HE. In addition, LE demonstrated higher amount of total phenolics, flavonoids and tannins indicating higher antioxidant effect compared to HE. For the evaluation of antidiarrheal effect in castor oil induced diarrheal mice, both extracts showed significant inhibition of defecation at doses 250 and 500 mg/kg body weight. Finally, for acetic acid-induced writhing method to evaluate the analgesic activity, significant percentage inhibition of writhing (P < 0.05 vs. control) was observed for both extracts at lower and higher doses. Altogether, these studies justified the plant’s usage in folklore medication.
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