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- 저자 : Takeshima, Teppei (검색결과 36 건)
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Takeshima, Hideyuki,Ikegami, Daigo,Wakabayashi, Mika,Niwa, Tohru,Kim, Young-Joon,Ushijima, Toshikazu IRL Press] ; Oxford University Press 2012 Carcinogenesis Vol.33 No.12
<P>A field for cancerization (field defect), where genetic and epigenetic alterations are accumulated in normal-appearing tissues, is involved in human carcinogenesis, especially cancers associated with chronic inflammation. Although aberrant DNA methylation is involved in the field defect and induced by chronic inflammation, it is still unclear for trimethylation of histone H3 lysine 27 (H3K27me3), which is involved in gene repression independent of DNA methylation and functions as a pre-mark for aberrant DNA methylation. In this study, using a mouse colitis model induced by dextran sulfate sodium (DSS), we aimed to clarify whether aberrant H3K27me3 is induced by inflammation and involved in a field defect. ChIP-on-chip analysis of colonic epithelial cells revealed that H3K27me3 levels were increased or decreased for 266 genomic regions by aging, and more extensively (23 increased and 3574 decreased regions) by colitis. Such increase or decrease of H3K27me3 was induced as early as 2 weeks after the initiation of DSS treatment, and persisted at least for 16 weeks even after the inflammation disappeared. Some of the aberrant H3K27me3 in colonic epithelial cells was carried over into colon tumors. Furthermore, H3K27me3 acquired at Dapk1 by colitis was followed by increased DNA methylation, supporting its function as a pre-mark for aberrant DNA methylation. These results demonstrated that aberrant H3K27me3 can be induced by exposure to a specific environment, such as colitis, and suggested that aberrant histone modification, in addition to aberrant DNA methylation, is involved in the formation of a field defect.</P>
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QUANTITY AND QUALITY OF DAILY PHYSICAL ACTIVITY IN COMMUNITY-DWELLING OLDER ADULTS IN JAPAN
Takeshima, Nobuo,Islam, Mohammod M.,Lee, Mi-Sook,Rogers, Michael E.,Rogers, Nicole L. 한국체육대학교 체육과학연구소 2001 국제학술대회논문집 Vol.20 No.1
Decrease in daily physical activity (DPA) leads to decline in fitness in older adults. Quantity and quality of daily PA in forty community-dwelling older adults (70 ± 6 yr; Male 15, Female 25) in Japan was determined in this study by using Lifecorder accelerometers (Suzuken Co., Japan). The Lifecorder accelerometer records and integrates displacement information when worn by an individual. Computer software calculates caloric expenditure, as well as the intensity of the activity. In addition, the Lifecorder estimates resting energy expenditure based on gender, age, height, and weight. In these participants, mean (±SD) totals of daily energy expenditure (TDEE) were 1577±188 kcal/day and step rate (SR) was 6944±4318 steps/day. Age was associated positively with 0 intensity DPA (r=0.48, p<0.05), negatively with TDEE (r=0.44, p<0.05) and moderate intensity DPA (r=0.48, p<0.05). This participants spent 95% period off day performing 0 intensity DPA. Quantity of DPA in these people may be adequate to enjoy health benefits as it conformed to the report of Japan Ministry of Health and Welfare(1996). However, quality of DPA should be improved by increasing higher intensity DPA to further improve their health. The results of this study also indicate that Lifecorder accelerometers are useful in determining quantity and quality of DPA in a relatively healthy older population.
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Yasuhiro Takeshima,Ai Okamoto,Shohei Yokoyama,Fumihiko Nishimura,Ichiro Nakagawa,Young-Soo Park,Hiroyuki Nakase 대한척추신경외과학회 2023 Neurospine Vol.20 No.1
Objective: Facet articular irregularity is associated with rapidly progressive degenerative cervical myelopathy (DCM). However, its significance compared with other known risk factors remains unknown. Therefore, this retrospective study aimed to clarify the potential impact of facet articular irregularity as a risk factor for rapid DCM progression. Methods: This study included 141 consecutive patients with DCM who underwent surgical treatment at our institution. Clinical variables and radiological findings related to DCM progression were collected. Imaging findings were analyzed at the segmental level of myelopathy in each case. The patients were divided into 2 groups based on the presence or absence of rapid DCM progression, and independent risk factors were determined using logistic regression analyses. Results: Overall, 131 patients with a mean age of 63.9 ± 12.6 years were analyzed; 27 patients (20.6%) were classified into the rapid DCM progression group. The mean age was significantly higher in the rapid progression group than in the slow progression group (72.4 ± 9.6 vs. 61.7 ± 12.4, p < 0.001). According to univariate analysis, facet articular irregularity, dynamic segmental translation (≥ 1.6 mm), upper cervical spine involvement above C4–5, history of cerebrovascular events, preceding minor trauma, local lordotic angle (≥ 4.5°), diabetes, hypertension, ligamentum flavum hypertrophy, and age were independent risk factors. Additionally, multivariate analysis showed that facet articular irregularity was the highest risk factor for rapid DCM progression (p = 0.001). Conclusion: Facet articular irregularity is the most clinically significant finding among the known risk factors in patients with rapid DCM progression.
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Ramelteon for Delayed Sleep-wake Phase Disorder: A Case Report
Masahiro Takeshima,Tetsuo Shimizu,Hiroyasu Ishikawa,Takashi Kanbayashi 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1
Recently developed melatonin receptor agonists are expected to be effective for delayed sleep-wake phase disorder (DSWPD). To date, however, no study has described the effect of melatonin receptor agonists on DSWPD. We report the case of a 15-year-old girl with DSWPD who was successfully treated with ramelteon 4 mg at 7 PM. DSWPD symptoms were resolved; her sleep-wake and biological rhythms were normalized.
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Successful Management of Clozapine-induced Akathisia with Gabapentin Enacarbil: A Case Report
Masahiro Takeshima,Hiroyasu Ishikawa,Yuka Kikuchi,Takashi Kanbayashi,Tetsuo Shimizu 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3
The management of clozapine (CLZ)-induced adverse events affects patient prognoses. Akathisia is a relatively rare adverse event related to CLZ administration and thus the management of this syndrome is not well established. Here, we report a case of treatment-resistant schizophrenia wherein CLZ-induced akathisia was successfully managed with gabapentin enacarbil (GE). The patient was a 39-year-old woman who had been treated with atypical antipsychotics other than CLZ for three years with poor tolerability. Initiation of CLZ (400 mg/day) attenuated her psychotic symptoms, but was followed by moderate akathisia. Neither benzodiazepines nor biperiden improved the akathisia; however, akathisia was finally diminished with co-administration of GE. GE facilitated a dosage increase in CLZ (450 mg/day) for the improved management of pyschotic symptoms, and thus indirectly contributed to treatment of the patient’s schizophrenia. We suggest that GE is a useful candidate for the management of CLZ-induced akathisia. The improved management of treatment-induced akathisia and other adverse events can extend the potential application of CLZ for treatment-resistant schizophrenia.
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Yasuhiro Takeshima,Hirokazu Takami,Toshiki Endo,Masaki Mizuno,Kazutoshi Hida 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Objective: This study aimed to clarify the relationship between recurrence and the extent of resection in surgery for intramedullary spinal hemangioblastoma (sHB) and its impact on von Hippel-Lindau (vHL) disease. Methods: Data on sHB cases followed up for at least 6 months after surgery were extracted from a nationwide registry of 1,033 consecutive spinal intramedullary tumors surgically treated between 2009 and 2020, and were retrospectively categorized into a sporadic or vHL group. The diagnosis of vHL disease was made at each institution based on clinical findings. Results: A total of 168 patients (sporadic group, 101; vHL group, 67) were included in the study. Compared with the sporadic group, the vHL group had a younger onset (45.4 ± 16.8 years vs. 39.6 ± 14.1 years, p = 0.02), more preoperative motor (47.5% vs. 68.7%, p < 0.01) and gait (37.6% vs. 61.2%, p < 0.01) impairments, and more patients with worsening neurological symptoms at discharge (p = 0.02). The gross total resection (GTR) rates and the recurrence rates were not statistically different between the sporadic and the vHL groups. GTR significantly improved recurrence-free survival compared to non-GTR in all patient analysis (p < 0.01) but this trend was not observed in the sporadic group. Physical functional improvement from discharge to 6 months after surgery was observed in the sporadic group (p < 0.01) but not in the vHL group. Conclusion: A high GTR rate may sufficiently decrease susceptibility to recurrence, especially in patients with sHB with vHL. In sporadic sHB, postoperative functional improvement can be expected, and the long-term functional prognosis is favorable.
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Ai Okamoto,Yasuhiro Takeshima,Shohei Yokoyama,Fumihiko Nishimura,Ichiro Nakagawa,Young-Soo Park,Hiroyuki Nakase 대한척추신경외과학회 2022 Neurospine Vol.19 No.2
Objective: To evaluate cervical facet joint degeneration using a newly developed classification, investigate its prevalence and relationship with cervical degenerative spondylolisthesis, and clarify its clinical significance in patients with degenerative cervical myelopathy (DCM). Methods: This study included 145 consecutive patients with DCM who underwent surgical treatment. Clinical variables and radiological findings were analyzed. A new 6-grade computed tomography (CT) classification for cervical facet joint degeneration was adapted, and its prevalence was evaluated by categorizing the joints into those at responsible and those at nonresponsible spinal segmental levels. We evaluated the association between rapidly progressive myelopathy and the presence of significant facet joint degeneration or spondylolisthesis at the responsible segmental level. Results: Finally, 140 patients with a mean age of 64.1 ± 12.8 years were analyzed. The prevalence of grade 1, 2, 3, 4, 5A, and 5B classification in all facet joints was 72.0%, 9.5%, 10.9%, 4.3%, 2.9%, and 0.4%, respectively. There was a statistically significant difference in the distribution of CT grades between the joints at the responsible and nonresponsible segmental levels (p < 0.001), with a high prevalence of grade 4 or 5B degeneration at the responsible segmental level, reflecting articular irregularity. There was also a statistically significant relationship between rapidly progressive myelopathy and grade 4 or 5B degeneration at the responsible segmental level (p < 0.001), but not between rapidly progressive myelopathy and spondylolisthesis (p = 0.255). Conclusion: This novel CT classification for facet joints deserves additional evaluation in patients with DCM. Abnormal findings on the articular surfaces might be related to the progression of myelopathy.
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Ultrasound visibility of regional anesthesia catheters: an in vitro study
Junji Takatani,,Naozumi Takeshima,Kentaro Okuda,Tetsuya Uchino,Takayuki Noguchi 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.63 No.1
Background: Ultrasound subjective visibility of in-plane needles is correlated with the intensity difference between the needle surface and the background. Regional anesthesia catheters are difficult to visualize by an ultrasound. In the present study, we investigated the ultrasound visibility of the catheters. Methods: Six catheters were placed at 0o and 30o relative to and at a depth of 1 cm below the pork phantom surface. Ultrasound images of in-plane catheters were evaluated, subjectively and objectively. Outer and inner objective visibilities were defined as the difference in the mean pixel intensity between the catheter surface and adjacent background, and between the surface and the center of the catheter, respectively. Evaluations were made based on the portion of the catheters. A P value < 0.05 was considered significant. Results: Subjective visibility was more strongly correlated with the inner objective visibility than with the outer objective visibility at both angles. Metallic 19-gauge catheters were more subjectively visible than the non-metallic 20-gauge catheters at 30o degrees (P < 0.01). Subjective, and outer and inner objective visibility were significantly lower at 30o than at 0o (P < 0.01, P < 0.01, P = 0.02). Perifix ONE at 0o and Perifix FX at 30o were the most visible catheters (P < 0.01 for both). Conclusions: Subjective visibility of catheters can not be evaluated in the same manner as that of the needles. For the best possible visualization, we recommend selecting a catheter with a structure that enhances the dark at the center of catheter, rather than basing the catheter selection on the bore size. Background: Ultrasound subjective visibility of in-plane needles is correlated with the intensity difference between the needle surface and the background. Regional anesthesia catheters are difficult to visualize by an ultrasound. In the present study, we investigated the ultrasound visibility of the catheters. Methods: Six catheters were placed at 0o and 30o relative to and at a depth of 1 cm below the pork phantom surface. Ultrasound images of in-plane catheters were evaluated, subjectively and objectively. Outer and inner objective visibilities were defined as the difference in the mean pixel intensity between the catheter surface and adjacent background, and between the surface and the center of the catheter, respectively. Evaluations were made based on the portion of the catheters. A P value < 0.05 was considered significant. Results: Subjective visibility was more strongly correlated with the inner objective visibility than with the outer objective visibility at both angles. Metallic 19-gauge catheters were more subjectively visible than the non-metallic 20-gauge catheters at 30o degrees (P < 0.01). Subjective, and outer and inner objective visibility were significantly lower at 30o than at 0o (P < 0.01, P < 0.01, P = 0.02). Perifix ONE at 0o and Perifix FX at 30o were the most visible catheters (P < 0.01 for both). Conclusions: Subjective visibility of catheters can not be evaluated in the same manner as that of the needles. For the best possible visualization, we recommend selecting a catheter with a structure that enhances the dark at the center of catheter, rather than basing the catheter selection on the bore size.
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