Alcoholics 환자와 Alcohol Dehydrogenase

정태호,신창규,이종학,강병조 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

저자들은 만성알콜중독의 원인으로 음주자의 성격, 사회요인 등 여러가지 문제들이 게재되어 있지만 유전적 요인도 중요하리라고 생각되어 만성알콜중독자로 진단되어 국립부곡정신병원에 입원가료 중인 환자 30명을 대상으로 ADH2의 다형현상(polymorphism)을 조사하여 알콜중독자가 아닌 건강한 한국인의 유전자형과 비교한 결과 다음과 같은 결과를 얻었다. 만성알콜중독자 30명 중 ADH2-1/ADH2-1 형을 갖는 사람이 27명이었으며 ADH2-1/ADH2-2를 갖는 사람이 3명이었다. ADH2¹의 gene frequencies는 0.68이었으며 ADH²의 gene frequencies는 0.32로서 정상 한국인과 비교하여 유의한 차이가 없었다. This study was performed to know the gene polymorphism of alcoholic dehydrogenase(ADH)-2 in 30 Korean alcohol addicted patients who were admitted at Bugok National Mental Hospital. The results were as follows ADH-2/ADH2-1 type among 30 alcohol addicts were 27 and ADH2-1/ADH2-2 type were 3. Gene frequencies of ADH2-1 were 0.68 and gene frequencies of ADH2-2 were 0.32 These results were not different from the gene polymorphism of ADH2 in non-alcoholic Korean healthy adults.

大學의 硏究機能

太正學 梨花女子大學校 韓國生活科學硏究院 1980 韓國生活科學硏究院 論叢 Vol.26 No.-

本 論文은 世界 特히 西獨, 英國, 美國, 日本의 여러 大學의 硏究機能을 比較 檢討하였다. 그래서 硏究機能이 大學에서 그 正常的인 活動을 하려고 하면 어떻게 하여야 하는 것을 考察하였다. 大學의 硏究機能은 다음의 세 가지 1) 學究的 硏究 2) 敎育을 위한 硏究 3) 技術開發이나 市民生活의 改善에 應用하기 위한 硏究로 分類된다. 硏究의 類型이 어떤 것이든 간에, 硏究 機能은 大學의 다른 機能과 密接不可離한 관계를 가지고 있고 서로 活性化시키는 데 중요한 役割을 하고 있다. 大學이 存續하는 限 硏究는 그 核心이고 따라서 不可避한 일이다. The author has compared the resarch function of universities around world, especially in Germany, England, America and Japan. In doing so, the author discussed how the normal research function should be realized. He also classified the types of research function into three according to their purposes, 1) academic research 2) research for education 3) research for application both to technology and citizen life. No matter how the types of research may be, research function activates the other part of university function. Reseach, therefore, is a core and inevitable matter at universities so long as it continues to act and to be alive.

低溫카륨의 電氣抵抗에 對한 Phonon 效果의 影響

太正學 梨花女子大學校 韓國生活科學硏究院 1977 韓國生活科學硏究院 論叢 Vol.19 No.-

電子에 영향을 주는 카륨 이온 全體에 의한 pseudopotential을 이용하여 電子-phonon의 相互作用을 一般的으로 計算하고 여기에 單一平面波 近似를 취하여 行列要素의 自乘形을 구했다. 電子와 phonon의 分布狀態의 可能한 여러 경우를 考察하여 Boltzman-Bloch 式에서의 衝突項을 計算하고 電場이 附加되지 않았을 때와 附加되었을 때의 電子와 phonon에 관한 方程式을 수립하였다. Phonon drag를 고려하여 試行函數 ^→k·^→u 에 비례하는 그 비례상수를 溫度의 函數로 前提하여 表現하였다. 이렇게 해서 決定된 試行函數를 Ziman의 變分法에 의한 電氣抵抗의 式에 代入하여 計算을 實施하였다. 그 결과 2˚~20˚K의 溫度 範圍內에서 Ekin과 Maxfield의 實驗과 비교해 볼 때 phonon drag 효과는 Kaveh와 Wiser의 결과와는 달리 그다지 重要하지 않다는 결론을 얻었다. 이에 대한 該細한 檢討를 하였다. A whole process of calculations is presented for the temperature dependuce of the electrical resistivity of potassium at temperature range(2˚~ 20˚K). In calculating the collision term, we take the trial function proportional to ^→k·^→u and the rate coefficient to be a function of temperature. Thus the phonon drag effect is considered. Comparing with the results of Ekin and Maxfield’s experiment, we find that phonon drag effect is not so much important in contrast to Kaveh and Wiser.

Josephson 效果와 量子力學的 觀測理論

太正學 梨花女子大學校 韓國生活科學硏究院 1984 韓國生活科學硏究院 論叢 Vol.34 No.-

觀測의 問題를 量子力學의 基礎가 되는 波動函數의 解釋과 結付시켜서 檢討하고 Ginzburg-Landau 理論에 根據하여 超傳導體 안에서의 秩序狀態를 위치에 의존하는 秩序 parameter와 量子力學에서의 波動函數와 連關시켰다. 超傳導體 狀態가 巨視的인 規模로 나타나는 Josephson 效果의 特性을 利用하여 cooper pair가 2개 超傳導體 사이의 位相差에 의하여 이동하는 것을 前提로 하여 對象系의 徵視現象과 觀測裝置하는 巨視現象간의 關係를 다리놓기 위한 基礎昨業을 檢討하였고 兩者간의 分離不可能性을 土臺로 量子力學에 固有한 一貫性 있는 관측이론을 追求하였다. A quantumn mechanical problem of measurements was examined by inter-preting the meaning of wave function, which is correlated to the order parameter. The parameter can be a applied to the theory of superconductivity in ordered states by Ginzburg-Landau. Josephson effects were proved to be a phenomenon of superconductivity in a large scale. It was attempted that two phenomenological regions, microscopic object system and macroscopic apparatus, are bridged by using the characteristic properties of the effects and movement of cooper pair due to phase difference between two pieces of superconductive metals. The author pursued to construct the proper and consistent theory of measurement in quantum mechanics on the basis of inseparability of regions.

상태공간모형을 이용한 연속회분식반응조의 상태 및 매개변수 추정

김동한,정태학 대한상하수도학회 2003 상하수도학회지 Vol.17 No.6

The model for a biological nutrient removal process has become essential for the design and operation. The statespace model based on the extended Kalman filter for a sequencing batch reactor process has been developed to reflect uncertainties and dynamics in a real process. It is feasible to estimate states included in the process model, which are not easily measured, by using the extended Kalman filter through the prediction and correction. It is also possible to simultaneously estimate states and parameters reflecting the characteristics of the process at various conditions. It is necessary to choose the suitable covariance matrix and to adopt parameters from observability in the estimation of states and parameters. In a sequencing batch reactor process observability may exist while the reactions related to measurements are proceeding. States and parameters converge rapidly to the real values while observability exists.

DO 동특성을 이용한 연속회분식반응조의 폭기공정 제어

김동한,정태학 대한상하수도학회 2003 상하수도학회지 Vol.17 No.6

As a sequencing batch reactor process is operated in the time orientation, it has flexibility of operation, which could easily accomodate aerobic, anoxic, and anaerobic conditions for biological nutrient removal in a reactor through the simple control of aeration. The aeration process of the sequencing batch reactor has been controlled on the basis of dissolved oxygen dynamics. Dissolved oxygen dynamics well represents the characteristics of reactions in a reactor. The first plateau of dissolved oxygen after aeration is related to the balance of oxygen, which is supplied by aeration and utilized by nitrification. The second rapid increase of dissolved oxygen is closely related to the end of nitrification. By applying the control strategy based on dissolved oxygen dynamics, aeration time for the optimal aerobic period is adjusted in a sequencing batch reactor. Aeration time is mainly correlated with the concentration of nitrogen in the influent and could also provide the characteristics of nitrification. The anoxic period could be prolonged through aeration control, so endogenous denitrification is maximized. The removal of phosphorus is enhanced simultaneously.

Alcoholics 환자와 Alcohol Dehydrogenase

강병조,이종학,신창규,정태호 대한생물치료정신의학회 1995 생물치료정신의학 Vol.1 No.2

저자들은 만성알콜중독의 원인으로 음주자의 성격, 사회요인 등 여러가지 문제들이 게재되어 있지만 유전적 요인도 중요하리라고 생각되어 만성알콜중독자로 진단되어 국립부곡정신병원에 입원가료 중인 환자 30명을 대상으로 ADH2의 다형현상(polymorphism)을 조사하여 알콜중독자가 아닌 건강한 한국인의 유전자형과 비교한 결과 다음과 같은 결과를 얻었다. 만성알콜중독자 30명 중 ADH2-1/ADH2-1 형을 갖는 사람이 27명이었으며 ADH2-1/ADH2-2를 갖는 사람이 3명이었다. ADH2¹의 gene frequencies는 0.68이었으며 ADH²의 gene frequencies는 0.32로서 정상 한국인과 비교하여 유의한 차이가 없었다. This study was performed to know the gene polymorphism of alcoholic dehydrogenase(ADH)-2 in 30 Korean alcohol addicted patients who were admitted at Bugok National Mental Hospital. The results were as follows ADH2-1/ADH2-1 type among 30 alcohol addicts were 27 and ADH2-1/ADH2-2 type were 3. Gene frequencies of ADH2-1 were 0.68 and gene frequencies of ADH2-2 were 0.32 These results were not different from the gene polymorphism of ADH2 in non-alcoholic Korean healthy adults.

하수의 유기물 분류에 미치는 동력학적 영향인자의 민감도 분석

최영균,김성홍,정태학 대한상하수도학회 2003 상하수도학회지 Vol.17 No.3

The effects of 6 kinetic parameters such as Y_H (yield coefficient of heterotrophs), b_H (decay rate of heterotrophs, /d), μ_HR (heterotrophic maximum specific growth rate on RBCOD, /d), μ_HS (heterotrophic maximum specific growth rate on SBCOD, /d), K_S (heterotrophic half saturation coefficient for RBCOD, ㎎COD/L) and K_X (heterotrophic half saturation coefficient for SBCOD) on the variation of RBCOD (readily biodegradable COD) concentration were analyzed during the COD fractionation of primary settled municipal wastewater by simulation of respirometric tests. Variation of RBCOD concentration was the highest when Y_H was changed within the acceptable range and standard deviation was about 48% of the averaged RBCOD concentration. Standard deviations of RBCOD concentration were about 10.4 and 6.3% of the averaged values when μ_HS and K_X were changed, respectively and it was about 6.5% when b_H was changed. The effects of μ_HR and K_S on RBCOD estimation were lower than the other kinetic parameters and the variations of RBCOD concentration were only about 2.2 and 3.5% of the averaged value when those two kinetic parameters were changed, respectively. Accordingly, hydrolysis or oxidation of SBCOD (slowly biodegradable COD) was more important than RBCOD oxidation during the analysis of respirometric test. It means that the variation of RBCOD concentration was more sensitive to the change of μ_HS and K_X than that of μ_HR and K_S because μ_HR and K_S did not directly affect the RBCOD concentration in wastewater. However, μ_HS and K_X could affect the RBCOD concentration through hydrolysis of SBCOD.

Cadmium Chloride가 흰쥐 신장에 미치는 영향에 관한 조직화학적 연구

이규식,백두진,김원규,정호삼,백태경,김영학 漢陽大學校 環境科學硏究所 1993 環境科學論文集 Vol.14 No.-

중공업의 발달에 따라 공장등지에서 중금속인 cadmium을 이용한 제품의 생산이 증가함에 따라 자연계내 토양, 물, 식물 등에 함유된 cadmium 뿐 아니라 공업제품과 공업 쓰레기에 함유된 cadmium은 쉽게 인체에 폭로되어 인체에 유해한 결과를 초래하게 된다고 알려져있다. 이에 저자는 cadmium이 생체내 신장에 특히 오랜기간 축적된다는 보고와 또 반감기가 긴 중금속이란 점에 착안하여 신장의 피질과 수질내 조직학적 변화를 관찰하고자 하였다. 실험동물은 사육실에서 순종 분리고 4년간 사육한 Wistar계 흰쥐를 사용하였다. 흰쥐에 체중 kg당 0.6mg의 cadmium chloride를 식염수 0.2ml에 용해하여 복강내로 10주간 매주 1회씩 투여한 후 희생기켜 신장조직을 paraffin 표본으로 제작하고 Mallory-Azan 염색을 시행하여 광학현미경으로 관찰한 후 다음과 같은 결과를 얻었다. 1. Cadmium chloride 10주간 투여후 1일 경과군에서 신장의 피질과 수질에 강한 Azan 염색반응을 보였으며 신사구체의 괴사와 수질 일부에서 간질성 섬유증식 및 울혈이 관찰되었다. 2. Cadmium chloride 10주간 투여후 1주 경과군에서는 신장의 피질과 수질에 중등도의 Azan 염색반응이 관찰되었고 신사구체의 국소적 괴사가 관찰되었다. 3. Cadmium chloride 10주간 투여후 2주 경과군에서는 신장의 피질에 중등도의 Azan 염색반응이 관찰되었으며, 4주 경과군에서는 피질과 수질에 약한 Azan 염색반응만 관찰되었다. 이상과 같은 결과로 미루어 cadmium chloride의 흰쥐에 장기간 투여는 미량이라도 신장의 신사구체의 괴사, 섬유화 등이 유발되나 투여후 4주 경과시는 손상이 회복되는 것으로 사료된다. The peritoneal injections of cadmium chloride(0.6mg/kg) per 1 week for 10 weeks were made. The cadmium chloride treated rats were sacrificed on 24 hours, 1 week, 2 weeks and 4 weeks after 10 weeks administration. And each of renal tissues from cadmium treated rat kidney was stained with Mallory Azan. 1. The severe glomerular necrosis, fibrosis and congestions in 1 day group were seen in the cadmium chloride treated rats medulla. 2. The moderately positive reaction for azan stain was seen in cortex and medulla of 1 week group in the cadmium chloride treated rats medulla. 3. The weakly positive reaction for azan stain was revealed in cortex and medulla of the rat kidenys on 2 weeks and 4 weeks after cadmium chloride administration for 10 weeks. It is concluded that the renal damage of rat resulted with administration of cadmium chloride may be recovered 4 weeks after injection.

연속회분식 반응조를 이용한 슬러지 소화에서 포기비율과 포기빈도가 슬러지 소화에 미치는 영향

김성홍,김희준,최영균,정태학 대한상하수도학회 2003 상하수도학회지 Vol.17 No.2

Lab-scale sequencing batch experiments were carried out to investigate the effects of aeration ratio and aeration interval on nitrogen and phosphorus transformation during the sludge digestion by intermittent aeration. The highest nitrification and denitrification efficiency could be obtained when the aeration ratio was 0.25. Nitrification inhibition caused by alkalinity deficit was not observed at the aeration ratio of 0.75, however denitrification was limited at this level of aeration ratio. Biological phosphorus accumulation was possible at the aeration ratio of 0.25, however it was not observed when the aeration ratio was over 0.5. Under the same condition of aeration ratio, aeration interval played an important role in phosphorus release. Soluble phosphorus concentration of digested sludge was about 1.5㎎/L when the aeration interval was 4 hr and that was much lower than the concentration (12-18㎎/L) when the aeration interval was 20-44 hrs.