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토끼에서 근육주사시 입자 크기에 따른 amoxicillin의 비교 약물동태학
박승춘,윤효인,오태광,장범수,배순이,조준형,정상희,이내경,김민규 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-
To investigate the pharmacokinetic difference between the two amoxicillin (AMX) particles in rabbits after intramuscular injection (i.m.), both of AMX-S (particle size: 10 ㎍) and AMX-L (particle size: 100 ㎍) were injected into New Zealand White rabbits (1.2±0.3 ㎏) at a dose rate of 10 ㎎/㎏ of body weight. In this study, serum AMX concentrations were detected by microbiological assay with E. coli BE 1186 which shows high antibiotic sensitivity. After i.m. administration, AMX-S and AMX-L were best fitted as 1-compartment model with the absorption and elimination phase. The biological half-life (T_1/2, _k10) of AMX-S is 4.06±1.09 h and that of AMX-L 4.76±0.69 h. The serum maximal concentration time (T_max) of AMX-S and AMX-L were 0.88±0.17 h and 0.77±0.11 h, respectively. Maximal AMX concentration (C_max) (AMX-S: 5.71±0.62 ㎍/㎖, AMX-L: 5.04±0.25 ㎍/㎖) in serum showed a significant difference (p<0.05). In terms of bioequivalance, however, there was no difference between the two AMX's after i.m. injection in the basis of C_max and AUC.
이성환,김준식,박근수,김명성,권태찬,김천수,이상락 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.1
A Clinical assessment of the 25 patients with dilated cardiomyopathy who were admitted to the Department of Pediatrics, Keimyung University Dong San Hospital from January, 1982 to June, 1993 was performed. The result were as follows: 1) Among 25 patients with dilated cardiomyopathy. 8(32%) were younger than 1 year of age at the time of admission. 2) Adriamycin toxicity was the only encountered etiologic factor in 1 patient. 3) On admission, hepatomegaly and tachycardia were noted in almost all patients. 4) The Chest X-rays showed cardiomegalies in all 25 patients, pulmonary vein congestions in 15(60%) and pleural effusion in 2(8%). 5) The electrocardiography showed left ventricular hypertrophy in 72% and supraventricular tachycardia in 32%. 6) The echocardiographic examination showed left ventricular dilatations in all patients and left atrial dilatations in 20(80%). 7) Of 18 patients who had followed mean period of 2.9 years, 10 patients died within 9 months after the diagnosis.
전태준(Tae Joon Chun),김동아(Dong A Kim) 한국사회체육학회 2013 한국사회체육학회지 Vol.0 No.52
In the age of globalization, the experience of hosting various mega international sports events and hav-ing diverse experience obtained from the international sports relationships have become one of significant motivators in emphasizing the importance of global abilities of outstanding sportsmen, the coming to the fore of such importance as the needs of the times means that the consciousness for presence and responsibility improvement of sports departments began to move. Cultivating talented sportsmen with strengthened global abilities for the future has significance in that it shows how younger generations in the Korean sports commu-nity live and adjust themselves to the future society, and it requires education paradigm shift in physical educa-tion departments to train talented and globalized sportsmen as a future growth engine. For the Korean sports community facing the globalization era, educating sportsmen with global abilities is an urgent task. For this, it is necessary to define the sportsmen with global abilities, and clarify their roles. In particular, the education should focus on cultivating sportsmen who combine extensive experience with theoretical background on the nature of the sport, and the sports department professionally strengthening sportsmen`s global abilities with the curriculum to communicate with a variety of fields should be opened for the further competitive Korean sports community having a wealth of globalized outstanding sportsmen.
Putative Association of ITGB1 Haplotype with the Clearance of HBV Infection
Park, Tae-Joon,Chun, Ji-Yong,Bae, Joon-Seol,Kim, Ja-Son Y.,Lee, Jin-Sol,Pasaje, Charisse Flerida,Park, Byung-Lae,Cheong, Hyun-Sub,Lee, Hyo-Suk,Kim, Yoon-Jun,Shin, Hyoung-Doo Korea Genome Organization 2010 Genomics & informatics Vol.8 No.1
Integrins are transmembrane receptor proteins that mediate cell-cell adhesion and cell-extracellular matrix (ECM) adhesion. The deregulation of cell-ECM adhesion and the abnormal expression of beta1 (${\beta}1$) integrins (ITGB1s) are involved in tumor development and metastasis. In the liver, the expression of integrins and ECM proteins can be a cause of hepatocellular carcinoma (HCC) development. We performed direct DNA sequencing of 24 individuals, and identified 23 sequence variants of ITGB1 polymorphisms. Among these 23 variants, 7 common variants were selected based on frequencies and linkage disequilibrium, and then genotyped in a larger-scale group of subjects (n=1,103). The genetic associations of ITGB1 polymorphisms with the clearance of HBV and HCC outcome of HBV patients were analyzed using logistic regression models and Cox relative hazard models. Although there was no significant association observed between the polymorphisms and the HCC outcome of HBV patients, the second most common haplotype (ITGB1 haplotype-2 [C-C-C-C-T-C-T]) was putatively associated with HBV clearance (OR=0.75, p=0.008 and $P^{corr}=0.05$). The minor allele frequency (MAF) of ITGB1 haplotype -2 of the spontaneously recovered (SR) group was significantly higher than that of the chronic carrier group (CC) (freq. = 0.248 vs. 0.199). The information derived from this study could be valuable for understanding the genetic factors involved in the clearance of HBV.
전태준(Chun, Tae-Joon),김동아(Kim, Dong-A) 한국체육과학회 2019 한국체육과학회지 Vol.28 No.6
This study aims to examine the effects of 16-weeks rhythm exercise participation on mild cognitive impairment. Analysis for this study was made by collecting data from 60 people who have continuously participated in exercise activity as member of aerobic dance, line dance, and sports dance club. The data pertaining to this study was gathered using a 1:1 interview with MMSE-DS which is made by previous studies(Kim et. al., 2010) and theories. SPSSWIN Version 23 was used to process the collected data. Frequency and Independent-samples t-test were utilized as tools of analysis. In accordance with the research method and process mentioned above, the study produced the following results. First, there were differences in cognitive impairment according to sample characteristics before and after 16-weeks rhythm exercise participation, but no significant. Second, there were significant differences in mild cognitive impairment before and after 16-weeks rhythm exercise participation in exercise activity according to type of group.
생활체육참가자의 운동중독과 대인관계 및 체면민감성의 관계
전태준(Tae Joon Chun) 한국사회체육학회 2009 한국사회체육학회지 Vol.0 No.38
This study aims to examine the degree of relationship between exercise addiction, interpersonal relations and susceptibility for social-face through participants in leisure sports. Using previous studies and theories as a foundation, the model of this study sets exercise addiction as the exogenous latent variable and interpersonal relations and susceptibility for social-face as endogenous latent variables to verify the hypothesis. Analysis for this study was made by collecting data from 680 residence from Seoul by method of purposive sampling. The data pertaining to this study was gathered using a self-administered survey questionnaire. SPSSWIN Version 15.0 and Amos Version 7 were both used to process the collected data. Structural equation modeling and ANOVA were utilized as tools of analysis. In accordance with the research method and process mentioned above, the study produced the following results. First, there is a significant difference in susceptibility for social-face. Second, a modified structural equation model of exercise addiction, interpersonal relations and susceptibility for social-face is adequate. And lastly, causal relationships within the modified structural equation model of exercise addiction, interpersonal relations and susceptibility for social-face were revealed between exercise addiction and susceptibility for social-face.