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전중균 ( Joong Kyun Jeon ),김병기 ( Pyong Kih Kim ),허형택 ( Hyung Tack Huh ) 한국수산학회 1995 한국수산과학회지 Vol.28 No.2
조피볼락, 잉어 및 무지개송어의 혈청을 상온(15℃), 저온(4℃), 냉동(-20℃)으로 보존하면서 총단백질(TP), 알부민(ALB), 중성지방(TG), 콜레스테롤(CHOL), 포도당(GLC), 인(P), 나트륨(Na), AST 및 ALT의 활성 변화를 상온과 저온에서는 16일까지, 냉동에서는 30일까지 조사하였다. 어종간에 다소의 차이가 있기는 하지만 대체로 단백질 성분인 TP, ALB과 당 성분인 GLC, 무기질인 P, Na의 농도는 안정하였고, 지방 성분인 TG와 CHOL, AST, ALT의 활성은 불안정하였다. 그리고 온도에 따른 혈액 성분의 안정성은 상온에서 보다는 저온과 냉동에서 대체로 안정하지만, 성분에 따라서는 냉동하여도 매우 불안정한 것이 있다. An attempt was made to elucidate the stability of serum metabolites and enzyme activities in blood samples taken from rockfish(Sebastes schlegeli), Israeli carp(Cyprinus carpio) and rainbow trout (Oncorhynchus mykiss) under different storing conditions. The concentrations of total protein(TP), albumin(ALB), triglyceride(TG), cholesterol(CHOL), glucose (GLC), phosphorus(P) and sodium(Na), and the activities of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in serum were investigated for 16 days at 15℃(room temp.) and 4℃(refrigerative) condition, or frozen at -20℃ for period of 30 days. Though there was a little difference between fish species, the concentrations of TP, ALB, GLC, P, Na in serum were stable at all storing temperatures, while those of TG, CHOL, ALT and AST were not stable, particularly even at the normal temperature. In general, serum components were more stable at refrigerative and frozen conditions than at room temp. storing. However, it was noticeable that the stability of CHOL in rockfish serum was found to be more unstable at -20℃ than kept at 15℃ or 4℃.
Kim, Tack-Joong,Jeon, Jinseon,Jin, Yong-Ri,Son, Dong-Ju,Yoo, Hwan-Soo,Hong, Jin-Tae,Ryu, Chung-Kyu,Shin, Hwa-Sup,Lee, Kwang-Ho,Yun, Yeo-Pyo Raven Press 2007 Journal of cardiovascular pharmacology Vol.49 No.5
<P>Hyperproliferation of platelet-derived growth factor (PDGF)-BB-induced vascular smooth muscle cell (VSMC) is a hallmark of atherosclerosis and related vascular disorders. In the previous study, we reported that KTJ740 [2-chloro-3-(4-(ethylcarboxy)-phenyl)-amino-1,4-naphthoquinone], a newly synthesized vitamin K derivative, has potent antithrombotic effects in mice and antiplatelet activity in vitro and ex vivo. In the present study, we have tested that KTJ740 could inhibit PDGF-BB-stimulated VSMC proliferation. We have examined the potential inhibitory effect of this compound on rat aortic smooth muscle cells (RASMCs). Our results show that this compound significantly inhibits PDGF-BB-stimulated RASMC number and DNA synthesis in a concentration-dependent manner. Furthermore, we have examined its effect on cell cycle progression by flow cytometry. KTJ740 treatment resulted in a significant arrest in cell cycle progression of RASMCs induced by PDGF-BB, and this effect was achieved by suppressing activation of PDGF-beta receptor (PDGF-Rbeta) tyrosine kinase pathway. These results suggest that a possibility of KTJ740 can be a potential agent to control vascular disorders and its antiproliferative mechanism may be mediated through PDGF-Rbeta tyrosine kinase-dependent signaling pathway.</P>
전중균 ( Joong Kyun Jeon ),김병기 ( Pyong Kih Kim ),박용주 ( Yong Joo Park ),허형택 ( Hyung Tack Huh ) 한국수산학회 1995 한국수산과학회지 Vol.28 No.2
우리 나라에서 많이 양식하고 있는 주요 어종의 혈액 성분에 관한 기초 자료를 얻기 위하여, 저수온기 (수온 12.7℃)에 월동중인 조피볼락(Sebastes schlegeli), 농어(Lateolarax japonicus), 넙치(Paralichthys olivaceus) , 돌돔(Oplegnathus fasciatus)과 함께 냉수성 어종인 은연어(Oncorhynchus kisutch)를 각 5~6마리씩 마취시키지 않은 상태로 꼬리 동맥에서 채혈하여 혈청 중의 총단백질(TP), 알부민(ALB), 중성 지방(TG), 콜레스테롤(CHOL), 포도당(GLC), 리파제(LIPA), 나트륨(Na), 칼륨(K), 염소(Cl), 인(P), 아미노산전이효소(ALT, AST) 등을 혈액분석기로 분석하였다. TP 농도는 2.9~5.1g/dl의 수준이었으며, ALB 농도는 1.2~1.9g/dl의 수준이었다. A/G 비는 은연어가 1.1 정도로 가장 높았고 나머지는 0.5~0.6 정도로 비슷하였다. 지질 성분인 TG와 CHOL 농도도 어종에 따라 달라, 넙치는 TG 농도가 큰 대신에 CHOL 농도가 낮았으며, 농어는 반대로 TG 농도가 낮은 대신에 CHOL 농도가 높았다. 두 지질 성분의 합은 넙치가 가장 많아 600㎎/dl나 되었고, 농어나 조피볼락(약 400㎎/dl), 돌돔이나 은연어(약 300㎎/dl)의 순이었다. 혈당(GLC) 농도는 냉수성 어종인 은연어가 넙치에 비해 약 4배 가량 많아 61~76㎎/dl이나 되었다. 한편 리파제(LIPA) 활성은 TG 농도와 정반대의 경향을 보여 은연어에서 가장 높았고, 넙치에서는 거의 확인되지 않았다. 무기질 중에서 Na, Cl과 K 농도는 160~204 mmol/l, 137~183mmol/l과 0.5~3.1mmol/l로 유사한 수준이었으나, P 농도는 은연어나 조피볼락처럼 비교적 활동성이 강한 어종일수록 많았다. ALT 활성은 넙치가 가장 높았고, AST 활성은 은연어가 높았으며, AST 활성은 모든 어종에서 ALT 활성보다 높았다. This study was performed to obtain the basic data on the serum components of several marine fish species commonly cultured in Korea. Blood samples taken from five species of fish were analyzed for various components of serum, total protein (TP), albumin (ALB), triglyceride (TG), cholesterol (CHOL), glucose (GLC), sodium (Na), potassium (K), chloride (CI), phosphorus (P), lipase (LIPA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The fish used were coho salmon (Oncorhynchus kisutch), rock fish (Sebastes schlegeli), sea bass (Lateolabrax japonicus), olive flounder (Paralichthys olivaceus) and parrot fish (Oplegnathus fasciatus) reared at the Chungmu Experimental Fish Culture Satation of KORDI. TP concentration of warm-water species (2.9~5.1g/dl) was higher than that of cold-water species, and ALB concentration was ranged at the level of 1.2~1.9g/dl. Coho salmon showed the highest ration of A/G(1.1), and the other species were about 0.5~0.6. The concentrations of TG and CHOL, components of lipids, varied with the different species. The concentration of TG was high, but CHOL concentration was low in olive flounder, while the reversed results were shown by sea bass. The sum of these two components was the highest with 600㎎/dl in olive flounder, and about 400㎎/dl for sea bass and rock fish, and 300㎎/dl for parrot fish and coho salmon. Concentration of GLC in coho salmon and rock fish ranged from 61 to 76㎎/dl which were about four times higher than that of flounder. The highest lipase activity was observed in coho salmon, while it was nearly nil in flounder. The reversed tendency was found for TG concentration. Mineral concentrations of Na, Cl and K were 160~204 mmol/1, 137~183mmol/1 and 0.5-3.1mmol/1, respectively, but no significant difference between the species was observed. However, the concentrations of P were high in relatively active species such as coho salmon and rockfish. AST activity in all species examined was higher than that of ALT with being highest in coho salmon. The highest ALT activity was found in olive flounder.
전중균,허형탁,Jeon, Joong-Kyun,Huh, Hyung-Tack 한국해양학회 1989 韓國海洋學會誌 Vol.24 No.2
Attempts were made to analyze the toxin composition of the toxic mussel Mytilus edulis galloprovincialis which were collected from aquaculture pond in Apr. 1988 in Hachung, Koje, southern Korea. The toxins were partially purified from the ethanolic extract of the mussel digestive glands by activated charcoal and Bio Gel P-2 column chromatography. HPLC analysis demonstrated that the toxin consisted mainly of gonyautoxin 1-4 (GTX 1-4), along with trace amounts of saxitoxin (STX) and protogonyautoxin 1-2 (PX 1-2).
한국산(韓國産) 주요(主要) 이매패류(二枚貝類)의 마비성패독(痲痺性貝毒) 독화상황(毒化狀況)
전중균,이순길,허경탁,Jeon, Joong-Kyun,Yi, Soon Kil,Huh, Hyung Tack 한국해양학회 1988 韓國海洋學會誌 Vol.23 No.3
The toxicity of bivalves in the Korean waters was investigated during 1987-1988. The toxicity of paralytic shellfish poison (PSP) was found in the sea mussels (Mytilus edulis galloprovincialis, M. corsucus), scallops (Patinopecten yessoensis, Chlamys farreri), tellin (Peronidia venulosa) and venus clam (Ruditapes philippinarum) among the 28 species screened. The toxicity in mussels, scallop (C. farreri) and venus clam was mainly confirmed from the samples collected around Jindong Bay in the southern coast of the peninsula, whereas the toxicities of tellin and scallop (P. yessoensis) were found in the vicinity of Pohang in the east coast. Samples from the west coast showed low levels of toxicity than those from the east arid south coasts. Although it varied with the regions, the toxicity was detected mainly during April to June, exceptionally during May to August in Pohang. The levels of toxicity were generally below the criteria of 4 mouse unit (MU)/g edible portion in foreign countries, with few exceptions.