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Rümeysa Taşdelen(Rümeysa Taşdelen ),Batuhan Ayık(Batuhan Ayık ),Hatice Kaya(Hatice Kaya ),Neslihan Sevimli(Neslihan Sevimli ) 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.3
Objective Retinal structural changes which were investigated by optical coherence tomography (OCT) have been reported in schizophrenia. Since cognitive dysfunction is a core feature of schizophrenia, the correlations between retinal findings and cognitive functions of patients and their healthy siblings may provide insight into the pathophysiological processes of the disorder. We aimed to investigate the relationship between neuropsychiatric tests and retinal changes in schizophrenia patients and their healthy siblings.Methods We measured OCT parameters and cognitive performance (via Trail Making Tests, verbal fluency tests, and The Digit Span Tests) of 72 participants (36 patients with schizophrenia and 36 healthy siblings) and disease severity (with Positive and Negative Syndrome Scale, Global Assessment of Functioning, and Clinical Global Impression scales) in patients with schizophrenia and evaluated the relationship between retinal findings and clinical parameters, especially neurocognitive tests.Results We found decreased ganglion cell layer-inner plexiform layer thickness and macular volume in the patient group. There were strong correlations between neurocognitive tests and OCT findings in both groups. On the other hand, there was not any correlation between retinal findings and disease parameters.Conclusion The cognitive symptoms of schizophrenia may be more closely related to structural changes in the retina.
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Learner-friendly textbooks: Chemistry texts based on a constructivist view of learning
Uğur Taşdelen 서울대학교 교육연구소 2008 Asia Pacific Education Review Vol.9 No.2
In this study, the use of inquiry methods, learning cycles, a conceptual change model and analogy in creating alternative science texts was discussed. An alternative text on the topic of acids and bases was created by integrating the methods and models discussed in this paper. The alternative text and a sample of a traditional text taken from a textbook, which is still used in Turkish high schools, were given to two groups, totaling 42 pre-service teachers-the alternative text was given to an experimental group and the traditional text to a control group-in an experimental setting and their understandings of acids and bases were compared. In addition, in the second step of the study, the pre-service teachers read both texts and indicated their preferences in terms of interest, understandability and helpfullness.
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On the Severity of Carpal Tunnel Syndrome: Diabetes or Metabolic Syndrome
Fatma Gul Yurdakul,Hatice Bodur,Özgu¨r Öztop Çakmak,Filiz Sivas,Filiz Eser,Özlem Yılmaz Taşdelen 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.3
Background and Purpose Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Although its etiology is unknown, certain conditions are commonly associated with CTS, such as obesity, arthritis, hypothyroidism, diabetes mellitus, trauma, mass lesions, amyloidosis, and sarcoidosis. We aimed to determine the association between metabolic syndrome and CTS, and we compared the severity of CTS between patients with diabetes (and no concomitant metabolic syndrome) and patients with metabolic syndrome. Methods Two hundred patients with a clinically and electrophysiological confrmed diagnosis of CTS were included in the study. Teir demographic characteristics and severity of CTS were analyzed according to the presence or the absence of metabolic syndrome. Diferences in the electrophysiological fndings were evaluated between the following four groups: 1) metabolic syndrome alone (n=52), 2) diabetes alone (n=20), 3) combined metabolic syndrome and diabetes (n=44), and 4) no metabolic syndrome or diabetes (n=84). Results CTS was more severe in the patients with metabolic syndrome than those without this syndrome. Te electrophysiological fndings were worse in patients with metabolic syndrome alone than in those with diabetes alone and those without diabetes and metabolic syndrome. Conclusions CTS appears to be more severe in patients with metabolic syndrome than patients with diabetes. Diabetes is one of the well-known risk factors for CTS, but other components of metabolic syndrome may have a greater efect on the severity of CTS.
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Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients
Mehmet Akif Camkurt,Fatih Karababa,Mehmet Emin Erdal,Hüseyin Bayazıt,Sultan Basmacı Kandemir,Mustafa Ertan Ay,Hasan Kandemir,Özlem İzci Ay,Erdinç Çiçek,Salih Selek,Bahar Taşdelen 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.3
Objective: The prevalence of schizophrenia is 1%, and it is a debilitating disorder that often results in a shortened lifespan. Peripheral blood samples are good candidates to investigate because they can be easily drawn, and they are widely studied in psychiatric disorders. MicroRNAs are small non-coding RNA transcripts. They regulate the expression of genes by binding to the 3’-untranslated region (UTR) of mRNAs and pointing them to degrade. In this study, we aimed to investigate the expression of miR-9-5p, miR-29a-3p, miR-106-5p, miR-106b-5p, miR-107, miR-125a-3p, and miR-125b-3p in schizophrenia patients and healthy controls. Methods: We collected blood samples from 16 patients with schizophrenia and 16 healthy controls. MicroRNAs were measured with reverse transcriptase polymerase chain reaction. Results: Schizophrenia patients showed statistically significant upregulation of five microRNAs: miR9-5p (p=0.002), miR29a-3p (p<0.001), miR106b-5p (p=0.002), miR125a-3p (p<0.001), and miR125b-3p (p=0.018). Conclusion: Our results increased the value of the miR106 and miR29 families as potentially and consistently dysregulated in psychiatric disorders. Our results should be considered preliminary, and they need confirmation in future studies with larger sample sizes.
KCI
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