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- 저자 : T.M. Al Tahtamouni (검색결과 2 건)
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Mustafa, Ebtihal H,Mahmoud, Huda T,Al-Hudhud, Mariam Y,Abdalla, Maher Y,Ahmad, Iman M,Yasin, Salem R,Elkarmi, Ali Z,Tahtamouni, Lubna H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Cancer metastasis depends on cell motility which is driven by cycles of actin polymerization and depolymerization. Reactive oxygen species (ROS) and metabolic oxidative stress have long been associated with cancer. ROS play a vital role in regulating actin dynamics that are sensitive to oxidative modification. The current work aimed at studying the effects of sub-lethal metabolic oxidative stress on actin cytoskeleton, focal adhesion and cell migration. Materials and Methods: T47D human breast cancer cells were treated with 2-deoxy-D-glucose (2DG), L-buthionine sulfoximine (BSO), or doxorubicin (DOX), individually or in combination, and changes in intracellular total glutathione and malondialdehyde (MDA) levels were measured. The expression of three major antioxidant enzymes was studied by immunoblotting, and cells were stained with fluorescent-phalloidin to evaluate changes in F-actin organization. In addition, cell adhesion and degradation ability were measured. Cell migration was studied using wound healing and transwell migration assays. Results: Our results show that treating T47D human breast cancer cells with drug combinations (2DG/BSO, 2DG/DOX, or BSO/DOX) decreased intracellular total glutathione and increased oxidized glutathione, lipid peroxidation, and cytotoxicity. In addition, the drug combinations caused a reduction in cell area and mitotic index, prophase arrest and a decreased ability to form invadopodia. The formation of F-actin aggregates was increased in treated T47D cells. Moreover, combination therapy reduced cell adhesion and the rate of cell migration. Conclusions: Our results suggest that exposure of T47D breast cancer cells to combination therapy reduces cell migration via effects on metabolic oxidative stress.
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Nguyen Le Minh Tri,김지태,Bach Long Giang,T.M. Al Tahtamouni,Pham Thi Huong,이창하,Nguyen Minh Viet,Do Quang Trung 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
In this study a novel Ag-doped graphitic carbon nitride (g-C3N4) photocatalyst was synthesized and appliedas high efficientmaterial under solarlight towardsemerging antibiotic pollutantin hospital wastewater. Thetetracycline (TC) was chosen as a target pollutant and the content of Ag doping at 3 mmol revealed thehighest photocatalytic degradation efficiency of TC (96.8%) after 120 min under solar light irradiation. Thephotoluminescence and UV–vis analysis confirmed the enhancement of charge separation and transfer inthe graphitic carbon structure after Ag-doping. The removal efficiency of TC using g-C3N4 and Ag-doped g-C3N4 (AgCN) underdark conditions was only 25.6 and 31.8%, respectively. While under solarlight conditions,the removal efficiency of TC increased to 68.3 and 96.8% for g-C3N4 and AgCN, respectively. The reusabilityprocess showed that AgCN displayed extremely high stability after 6 cycles without significant drop inantibiotic degradation efficiency. The application of AgCN was tested for treatment of TC from hospitalwastewater and it showed high removal efficiency of 89.6% within 120 min reaction time. In addition, theintermediatesgeneratedandreductionof total organiccarbon(TOC)duringthephotocatalyticreactionweredetected to support information of possible TC removal mechanism.
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