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RISS 인기검색어
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- 저자 : T. Rajamohan (검색결과 1 건)
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Beneficial Effects of Coconut Water Feeding on Lipid Metabolism in Cholesterol-Fed Rats
T. Rajamohan,V.G. Sandhya 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
The purpose of this study was to determine the effect of coconut water feeding in cholesterol-fed rats. Maleterol feeding caused a marked increase in total cholesterol, very low-density lipoprotein (VLDL). low-density lipoprotein(LDL) cholesterol, and triglycerides in serum. Administration of coconut water counteracts the increase in total cholesterol,VLDL. LDL cholesterol, and triglycerides, while high-density lipoprotein cholesterol was higher. Lipid levels in the tissuesviz. liver, heart, kidney, and aorta were markedly decreased in cholesterol-fed rats supplemented with coconut water. Feed-ing coconut water resulted in increased activities of 3-hydroxy-3-methylglutaryl-CoA reductase in liver, lipoprotein lipase inheart and adipose tissue, and plasma lecithin:cholesterol acyl transferase, while lipogenic enzymes showed decreased activites.An increased rate of cholesterol conversion to bile acid and an increased excretion of bile acids and neutral sterols were ob-served in rats fed coconut water. Histopathological studies of liver and aorta revealed much less fatty accumulation in thesetissues in cholesterol-fed rats supplemented with coconut water. Feeding coconut water resulted in increased plasma L-argi-nine content, urinary nitrite level, and nitric oxide synthase activity. These results indicate that both tender and mature co-conut water has beneficial effects on serum and tissue lipid parameters in rats fed cholesterol-containing diet.
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